node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CUL4B | UBC | ENSP00000384109 | ENSP00000344818 | cullin 4B | ubiquitin C | 0.978 |
DYRK2 | UBC | ENSP00000342105 | ENSP00000344818 | dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2; Serine/threonine-protein kinase involved in the regulation of the mitotic cell cycle, cell proliferation, apoptosis, organization of the cytoskeleton and neurite outgrowth. Functions in part via its role in ubiquitin-dependent proteasomal protein degradation. Functions downstream of ATM and phosphorylates p53/TP53 at ’Ser-46’, and thereby contributes to the induction of apoptosis in response to DNA damage. Phosphorylates NFATC1, and thereby inhibits its accumulation in the nucleus and its transcription factor activity. P [...] | ubiquitin C | 0.818 |
FDXACB1 | RBMXL2 | ENSP00000260257 | ENSP00000304139 | ferredoxin-fold anticodon binding domain containing 1 | RNA binding motif protein, X-linked-like 2 | 0.644 |
MAP1LC3A | UBC | ENSP00000363970 | ENSP00000344818 | microtubule-associated protein 1 light chain 3 alpha; Involved in formation of autophagosomal vacuoles (autophagosomes) | ubiquitin C | 0.945 |
MAP1LC3B | UBC | ENSP00000268607 | ENSP00000344818 | microtubule-associated protein 1 light chain 3 beta; Involved in formation of autophagosomal vacuoles (autophagosomes) | ubiquitin C | 0.545 |
PRMT2 | UBC | ENSP00000347906 | ENSP00000344818 | protein arginine methyltransferase 2; Arginine methyltransferase that methylates the guanidino nitrogens of arginyl residues in proteins such as STAT3, FBL, histone H4. Acts as a coactivator (with NCOA2) of the androgen receptor (AR)-mediated transactivation. Acts as a coactivator (with estrogen) of estrogen receptor (ER)-mediated transactivation. Enhances PGR, PPARG, RARA-mediated transactivation. May inhibit NF-kappa-B transcription and promote apoptosis. Represses E2F1 transcriptional activity (in a RB1- dependent manner). May be involved in growth regulation | ubiquitin C | 0.442 |
RABGGTA | RBMXL2 | ENSP00000216840 | ENSP00000304139 | Rab geranylgeranyltransferase, alpha subunit; Catalyzes the transfer of a geranyl-geranyl moiety from geranyl-geranyl pyrophosphate to both cysteines in Rab proteins with an -XXCC, -XCXC and -CCXX C-terminal, such as RAB1A, RAB3A and RAB5A respectively | RNA binding motif protein, X-linked-like 2 | 0.644 |
RABGGTA | UBC | ENSP00000216840 | ENSP00000344818 | Rab geranylgeranyltransferase, alpha subunit; Catalyzes the transfer of a geranyl-geranyl moiety from geranyl-geranyl pyrophosphate to both cysteines in Rab proteins with an -XXCC, -XCXC and -CCXX C-terminal, such as RAB1A, RAB3A and RAB5A respectively | ubiquitin C | 0.798 |
RBMXL2 | FDXACB1 | ENSP00000304139 | ENSP00000260257 | RNA binding motif protein, X-linked-like 2 | ferredoxin-fold anticodon binding domain containing 1 | 0.644 |
RBMXL2 | RABGGTA | ENSP00000304139 | ENSP00000216840 | RNA binding motif protein, X-linked-like 2 | Rab geranylgeranyltransferase, alpha subunit; Catalyzes the transfer of a geranyl-geranyl moiety from geranyl-geranyl pyrophosphate to both cysteines in Rab proteins with an -XXCC, -XCXC and -CCXX C-terminal, such as RAB1A, RAB3A and RAB5A respectively | 0.644 |
RBMXL2 | TRA2B | ENSP00000304139 | ENSP00000416959 | RNA binding motif protein, X-linked-like 2 | transformer 2 beta homolog (Drosophila); Sequence-specific RNA-binding protein which participates in the control of pre-mRNA splicing. Can either activate or suppress exon inclusion. Acts additively with RBMX to promote exon 7 inclusion of the survival motor neuron SMN2. Activates the splicing of MAPT/Tau exon 10. Alters pre-mRNA splicing patterns by antagonizing the effects of splicing regulators, like RBMX. Binds to the AG-rich SE2 domain in the SMN exon 7 RNA. Binds to pre- mRNA | 0.689 |
RBMXL2 | UBC | ENSP00000304139 | ENSP00000344818 | RNA binding motif protein, X-linked-like 2 | ubiquitin C | 0.626 |
TRA2B | RBMXL2 | ENSP00000416959 | ENSP00000304139 | transformer 2 beta homolog (Drosophila); Sequence-specific RNA-binding protein which participates in the control of pre-mRNA splicing. Can either activate or suppress exon inclusion. Acts additively with RBMX to promote exon 7 inclusion of the survival motor neuron SMN2. Activates the splicing of MAPT/Tau exon 10. Alters pre-mRNA splicing patterns by antagonizing the effects of splicing regulators, like RBMX. Binds to the AG-rich SE2 domain in the SMN exon 7 RNA. Binds to pre- mRNA | RNA binding motif protein, X-linked-like 2 | 0.689 |
TRA2B | UBC | ENSP00000416959 | ENSP00000344818 | transformer 2 beta homolog (Drosophila); Sequence-specific RNA-binding protein which participates in the control of pre-mRNA splicing. Can either activate or suppress exon inclusion. Acts additively with RBMX to promote exon 7 inclusion of the survival motor neuron SMN2. Activates the splicing of MAPT/Tau exon 10. Alters pre-mRNA splicing patterns by antagonizing the effects of splicing regulators, like RBMX. Binds to the AG-rich SE2 domain in the SMN exon 7 RNA. Binds to pre- mRNA | ubiquitin C | 0.804 |
UBC | CUL4B | ENSP00000344818 | ENSP00000384109 | ubiquitin C | cullin 4B | 0.978 |
UBC | DYRK2 | ENSP00000344818 | ENSP00000342105 | ubiquitin C | dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2; Serine/threonine-protein kinase involved in the regulation of the mitotic cell cycle, cell proliferation, apoptosis, organization of the cytoskeleton and neurite outgrowth. Functions in part via its role in ubiquitin-dependent proteasomal protein degradation. Functions downstream of ATM and phosphorylates p53/TP53 at ’Ser-46’, and thereby contributes to the induction of apoptosis in response to DNA damage. Phosphorylates NFATC1, and thereby inhibits its accumulation in the nucleus and its transcription factor activity. P [...] | 0.818 |
UBC | MAP1LC3A | ENSP00000344818 | ENSP00000363970 | ubiquitin C | microtubule-associated protein 1 light chain 3 alpha; Involved in formation of autophagosomal vacuoles (autophagosomes) | 0.945 |
UBC | MAP1LC3B | ENSP00000344818 | ENSP00000268607 | ubiquitin C | microtubule-associated protein 1 light chain 3 beta; Involved in formation of autophagosomal vacuoles (autophagosomes) | 0.545 |
UBC | PRMT2 | ENSP00000344818 | ENSP00000347906 | ubiquitin C | protein arginine methyltransferase 2; Arginine methyltransferase that methylates the guanidino nitrogens of arginyl residues in proteins such as STAT3, FBL, histone H4. Acts as a coactivator (with NCOA2) of the androgen receptor (AR)-mediated transactivation. Acts as a coactivator (with estrogen) of estrogen receptor (ER)-mediated transactivation. Enhances PGR, PPARG, RARA-mediated transactivation. May inhibit NF-kappa-B transcription and promote apoptosis. Represses E2F1 transcriptional activity (in a RB1- dependent manner). May be involved in growth regulation | 0.442 |
UBC | RABGGTA | ENSP00000344818 | ENSP00000216840 | ubiquitin C | Rab geranylgeranyltransferase, alpha subunit; Catalyzes the transfer of a geranyl-geranyl moiety from geranyl-geranyl pyrophosphate to both cysteines in Rab proteins with an -XXCC, -XCXC and -CCXX C-terminal, such as RAB1A, RAB3A and RAB5A respectively | 0.798 |