Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small nodes:
protein of unknown 3D structure
protein of unknown 3D structure
large nodes:
some 3D structure is known or predicted
some 3D structure is known or predicted
Node Color
colored nodes:
query proteins and first shell of interactors
query proteins and first shell of interactors
white nodes:
second shell of interactors
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Your Input:
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 | SART3 | squamous cell carcinoma antigen recognized by T cells 3; Regulates Tat transactivation activity through direct interaction. May be a cellular factor for HIV-1 gene expression and viral replication (963 aa) | ||
 | VASP | vasodilator-stimulated phosphoprotein; Ena/VASP proteins are actin-associated proteins involved in a range of processes dependent on cytoskeleton remodeling and cell polarity such as axon guidance, lamellipodial and filopodial dynamics, platelet activation and cell migration. VASP promotes actin filament elongation. It protects the barbed end of growing actin filaments against capping and increases the rate of actin polymerization in the presence of capping protein. VASP stimulates actin filament elongation by promoting the transfer of profilin- bound actin monomers onto the barbed end [...] (380 aa) | ||
 | HSPB1 | heat shock 27kDa protein 1 (205 aa) | ||
 | POLA2 | polymerase (DNA directed), alpha 2, accessory subunit; May play an essential role at the early stage of chromosomal DNA replication by coupling the polymerase alpha/primase complex to the cellular replication machinery (By similarity) (598 aa) | ||
 | RPP25L | ribonuclease P/MRP 25kDa subunit-like; May be a component of ribonuclease P or MRP (163 aa) | ||
 | COPS6 | COP9 constitutive photomorphogenic homolog subunit 6 (Arabidopsis); Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8, possibly via its association with [...] (327 aa) | ||
 | POP7 | processing of precursor 7, ribonuclease P/MRP subunit (S. cerevisiae); Component of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5’-ends (140 aa) | ||
 | SNRPN | small nuclear ribonucleoprotein polypeptide N; May be involved in tissue-specific alternative RNA processing events (240 aa) | ||
 | EIF4EBP3 | eukaryotic translation initiation factor 4E binding protein 3; Regulates eIF4E activity by preventing its assembly into the eIF4F complex (100 aa) | ||
 | RPP25 | ribonuclease P/MRP 25kDa subunit; Component of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5’-ends. Also a component of RNase MRP. This subunit binds to RNA (199 aa) | ||
 | UBE2O | ubiquitin-conjugating enzyme E2O (1292 aa) | ||
 | EPB41L1 | erythrocyte membrane protein band 4.1-like 1 (881 aa) | ||
 | POP1 | processing of precursor 1, ribonuclease P/MRP subunit (S. cerevisiae); Component of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5’-ends. Also a component of RNase MRP (1024 aa) | ||
 | UBC | ubiquitin C (685 aa) | ||
 | EIF4EBP2 | eukaryotic translation initiation factor 4E binding protein 2; Regulates eIF4E activity by preventing its assembly into the eIF4F complex. Mediates the regulation of protein translation by hormones, growth factors and other stimuli that signal through the MAP kinase pathway (120 aa) | ||
 | RPP38 | ribonuclease P/MRP 38kDa subunit; Component of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5’-ends. RPP38 may associate transiently with RNase P RNA as a factor involved in the transport of H1 RNA to the putative site of its assembly in the cell, the nucleolus (283 aa) | ||
 | RPP40 | ribonuclease P/MRP 40kDa subunit; Component of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5’-ends (363 aa) | ||
 | SMN1 | survival of motor neuron 1, telomeric; The SMN complex plays an essential role in spliceosomal snRNP assembly in the cytoplasm and is required for pre-mRNA splicing in the nucleus. It may also play a role in the metabolism of snoRNPs (294 aa) | ||
 | SMN2 | survival of motor neuron 2, centromeric (294 aa) | ||
 | CUL4B | cullin 4B (913 aa) | ||
 | RPP30 | ribonuclease P/MRP 30kDa subunit; Component of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5’-ends (322 aa) | ||
 | ATG12 | autophagy related 12; Ubiquitin-like protein involved in autophagy vesicles formation. Conjugation with ATG5 through an ubiquitin-like conjugating system involving also ATG7 as an E1-like activating enzyme and ATG10 as an E2-like conjugating enzyme, is essential for its function. The ATG12-ATG5 conjugate acts as an E3-like enzyme which is required for lipidation of ATG8 family proteins and their association to the vesicle membranes. The ATG12-ATG5 conjugate also regulates negatively the innate antiviral immune response by blocking the type I IFN production pathway through direct associ [...] (140 aa) | ||
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
Other names: H. sapiens, Homo, Homo sapiens, human, man
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