node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
DGKI | RAP1A | ENSP00000288490 | ENSP00000348786 | diacylglycerol kinase, iota | RAP1A, member of RAS oncogene family; Induces morphological reversion of a cell line transformed by a Ras oncogene. Counteracts the mitogenic function of Ras, at least partly because it can interact with Ras GAPs and RAF in a competitive manner | 0.728 |
DGKI | RASGRP3 | ENSP00000288490 | ENSP00000384192 | diacylglycerol kinase, iota | RAS guanyl releasing protein 3 (calcium and DAG-regulated); Guanine nucleotide exchange factor (GEF) for Ras and Rap1 | 0.742 |
HRAS | KNDC1 | ENSP00000309845 | ENSP00000304437 | v-Ha-ras Harvey rat sarcoma viral oncogene homolog; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity | kinase non-catalytic C-lobe domain (KIND) containing 1; Probable guanine nucleotide exchange factor (GEF) | 0.646 |
HRAS | KRAS | ENSP00000309845 | ENSP00000256078 | v-Ha-ras Harvey rat sarcoma viral oncogene homolog; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity | v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity | 0.901 |
HRAS | NRAS | ENSP00000309845 | ENSP00000358548 | v-Ha-ras Harvey rat sarcoma viral oncogene homolog; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity | neuroblastoma RAS viral (v-ras) oncogene homolog; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity | 0.901 |
HRAS | RASGRP3 | ENSP00000309845 | ENSP00000384192 | v-Ha-ras Harvey rat sarcoma viral oncogene homolog; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity | RAS guanyl releasing protein 3 (calcium and DAG-regulated); Guanine nucleotide exchange factor (GEF) for Ras and Rap1 | 0.926 |
KNDC1 | HRAS | ENSP00000304437 | ENSP00000309845 | kinase non-catalytic C-lobe domain (KIND) containing 1; Probable guanine nucleotide exchange factor (GEF) | v-Ha-ras Harvey rat sarcoma viral oncogene homolog; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity | 0.646 |
KNDC1 | KRAS | ENSP00000304437 | ENSP00000256078 | kinase non-catalytic C-lobe domain (KIND) containing 1; Probable guanine nucleotide exchange factor (GEF) | v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity | 0.710 |
KNDC1 | MAP2 | ENSP00000304437 | ENSP00000353508 | kinase non-catalytic C-lobe domain (KIND) containing 1; Probable guanine nucleotide exchange factor (GEF) | microtubule-associated protein 2; The exact function of MAP2 is unknown but MAPs may stabilize the microtubules against depolymerization. They also seem to have a stiffening effect on microtubules | 0.411 |
KNDC1 | NRAS | ENSP00000304437 | ENSP00000358548 | kinase non-catalytic C-lobe domain (KIND) containing 1; Probable guanine nucleotide exchange factor (GEF) | neuroblastoma RAS viral (v-ras) oncogene homolog; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity | 0.646 |
KNDC1 | RAP1A | ENSP00000304437 | ENSP00000348786 | kinase non-catalytic C-lobe domain (KIND) containing 1; Probable guanine nucleotide exchange factor (GEF) | RAP1A, member of RAS oncogene family; Induces morphological reversion of a cell line transformed by a Ras oncogene. Counteracts the mitogenic function of Ras, at least partly because it can interact with Ras GAPs and RAF in a competitive manner | 0.405 |
KRAS | HRAS | ENSP00000256078 | ENSP00000309845 | v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity | v-Ha-ras Harvey rat sarcoma viral oncogene homolog; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity | 0.901 |
KRAS | KNDC1 | ENSP00000256078 | ENSP00000304437 | v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity | kinase non-catalytic C-lobe domain (KIND) containing 1; Probable guanine nucleotide exchange factor (GEF) | 0.710 |
KRAS | NRAS | ENSP00000256078 | ENSP00000358548 | v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity | neuroblastoma RAS viral (v-ras) oncogene homolog; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity | 0.901 |
KRAS | RASGRP3 | ENSP00000256078 | ENSP00000384192 | v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity | RAS guanyl releasing protein 3 (calcium and DAG-regulated); Guanine nucleotide exchange factor (GEF) for Ras and Rap1 | 0.908 |
MAP2 | KNDC1 | ENSP00000353508 | ENSP00000304437 | microtubule-associated protein 2; The exact function of MAP2 is unknown but MAPs may stabilize the microtubules against depolymerization. They also seem to have a stiffening effect on microtubules | kinase non-catalytic C-lobe domain (KIND) containing 1; Probable guanine nucleotide exchange factor (GEF) | 0.411 |
NRAS | HRAS | ENSP00000358548 | ENSP00000309845 | neuroblastoma RAS viral (v-ras) oncogene homolog; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity | v-Ha-ras Harvey rat sarcoma viral oncogene homolog; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity | 0.901 |
NRAS | KNDC1 | ENSP00000358548 | ENSP00000304437 | neuroblastoma RAS viral (v-ras) oncogene homolog; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity | kinase non-catalytic C-lobe domain (KIND) containing 1; Probable guanine nucleotide exchange factor (GEF) | 0.646 |
NRAS | KRAS | ENSP00000358548 | ENSP00000256078 | neuroblastoma RAS viral (v-ras) oncogene homolog; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity | v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity | 0.901 |
NRAS | RASGRP3 | ENSP00000358548 | ENSP00000384192 | neuroblastoma RAS viral (v-ras) oncogene homolog; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity | RAS guanyl releasing protein 3 (calcium and DAG-regulated); Guanine nucleotide exchange factor (GEF) for Ras and Rap1 | 0.900 |