node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CDV3 | MPLKIP | ENSP00000264993 | ENSP00000304553 | CDV3 homolog (mouse) | M-phase specific PLK1 interacting protein; May play a role in maintenance of cell cycle integrity by regulating mitosis or cytokinesis | 0.644 |
CDV3 | NDUFA7 | ENSP00000264993 | ENSP00000470609 | CDV3 homolog (mouse) | NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 7, 14.5kDa; Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone | 0.895 |
CDV3 | SUGP1 | ENSP00000264993 | ENSP00000247001 | CDV3 homolog (mouse) | SURP and G patch domain containing 1; Plays a role in pre-mRNA splicing | 0.886 |
MPLKIP | CDV3 | ENSP00000304553 | ENSP00000264993 | M-phase specific PLK1 interacting protein; May play a role in maintenance of cell cycle integrity by regulating mitosis or cytokinesis | CDV3 homolog (mouse) | 0.644 |
MPLKIP | MRPL53 | ENSP00000304553 | ENSP00000258105 | M-phase specific PLK1 interacting protein; May play a role in maintenance of cell cycle integrity by regulating mitosis or cytokinesis | mitochondrial ribosomal protein L53 | 0.898 |
MPLKIP | NDUFA7 | ENSP00000304553 | ENSP00000470609 | M-phase specific PLK1 interacting protein; May play a role in maintenance of cell cycle integrity by regulating mitosis or cytokinesis | NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 7, 14.5kDa; Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone | 0.644 |
MPLKIP | PPIF | ENSP00000304553 | ENSP00000225174 | M-phase specific PLK1 interacting protein; May play a role in maintenance of cell cycle integrity by regulating mitosis or cytokinesis | peptidylprolyl isomerase F; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Involved in regulation of the mitochondrial permeability transition pore (mPTP). It is proposed that its association with the mPTP is masking a binding site for inhibiting inorganic phosphate (Pi) and promotes the open probablity of the mPTP leading to apoptosis or necrosis; the requirement of the PPIase activity for this function is debated. In cooperation with mitochondrial TP53 is involved in activating oxidative stress- i [...] | 0.644 |
MPLKIP | RBM27 | ENSP00000304553 | ENSP00000265271 | M-phase specific PLK1 interacting protein; May play a role in maintenance of cell cycle integrity by regulating mitosis or cytokinesis | RNA binding motif protein 27 | 0.905 |
MPLKIP | SARNP | ENSP00000304553 | ENSP00000337632 | M-phase specific PLK1 interacting protein; May play a role in maintenance of cell cycle integrity by regulating mitosis or cytokinesis | SAP domain containing ribonucleoprotein; Binds both single-stranded and double-stranded DNA with higher affinity for the single-stranded form. Specifically binds to scaffold/matrix attachment region DNA. Also binds single- stranded RNA. Enhances RNA unwinding activity of DDX39A. May participate in important transcriptional or translational control of cell growth, metabolism and carcinogenesis | 0.644 |
MPLKIP | SBDS | ENSP00000304553 | ENSP00000246868 | M-phase specific PLK1 interacting protein; May play a role in maintenance of cell cycle integrity by regulating mitosis or cytokinesis | Shwachman-Bodian-Diamond syndrome; Required for the assembly of mature ribosomes and ribosome biogenesis. Together with EFTUD1, triggers the GTP- dependent release of EIF6 from 60S pre-ribosomes in the cytoplasm, thereby activating ribosomes for translation competence by allowing 80S ribosome assembly and facilitating EIF6 recycling to the nucleus, where it is required for 60S rRNA processing and nuclear export. Required for normal levels of protein synthesis. May play a role in cellular stress resistance. May play a role in cellular response to DNA damage. May play a role in cell prol [...] | 0.907 |
MPLKIP | SCP2 | ENSP00000304553 | ENSP00000360569 | M-phase specific PLK1 interacting protein; May play a role in maintenance of cell cycle integrity by regulating mitosis or cytokinesis | sterol carrier protein 2; Mediates in vitro the transfer of all common phospholipids, cholesterol and gangliosides between membranes. May play a role in regulating steroidogenesis | 0.644 |
MPLKIP | SERPINH1 | ENSP00000304553 | ENSP00000350894 | M-phase specific PLK1 interacting protein; May play a role in maintenance of cell cycle integrity by regulating mitosis or cytokinesis | serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1); Binds specifically to collagen. Could be involved as a chaperone in the biosynthetic pathway of collagen | 0.659 |
MPLKIP | SF1 | ENSP00000304553 | ENSP00000366604 | M-phase specific PLK1 interacting protein; May play a role in maintenance of cell cycle integrity by regulating mitosis or cytokinesis | splicing factor 1 | 0.644 |
MPLKIP | SUGP1 | ENSP00000304553 | ENSP00000247001 | M-phase specific PLK1 interacting protein; May play a role in maintenance of cell cycle integrity by regulating mitosis or cytokinesis | SURP and G patch domain containing 1; Plays a role in pre-mRNA splicing | 0.902 |
MPLKIP | THY1 | ENSP00000304553 | ENSP00000284240 | M-phase specific PLK1 interacting protein; May play a role in maintenance of cell cycle integrity by regulating mitosis or cytokinesis | Thy-1 cell surface antigen; May play a role in cell-cell or cell-ligand interactions during synaptogenesis and other events in the brain | 0.906 |
MRPL53 | MPLKIP | ENSP00000258105 | ENSP00000304553 | mitochondrial ribosomal protein L53 | M-phase specific PLK1 interacting protein; May play a role in maintenance of cell cycle integrity by regulating mitosis or cytokinesis | 0.898 |
MRPL53 | PPIF | ENSP00000258105 | ENSP00000225174 | mitochondrial ribosomal protein L53 | peptidylprolyl isomerase F; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Involved in regulation of the mitochondrial permeability transition pore (mPTP). It is proposed that its association with the mPTP is masking a binding site for inhibiting inorganic phosphate (Pi) and promotes the open probablity of the mPTP leading to apoptosis or necrosis; the requirement of the PPIase activity for this function is debated. In cooperation with mitochondrial TP53 is involved in activating oxidative stress- i [...] | 0.909 |
MRPL53 | RBM27 | ENSP00000258105 | ENSP00000265271 | mitochondrial ribosomal protein L53 | RNA binding motif protein 27 | 0.960 |
MRPL53 | SBDS | ENSP00000258105 | ENSP00000246868 | mitochondrial ribosomal protein L53 | Shwachman-Bodian-Diamond syndrome; Required for the assembly of mature ribosomes and ribosome biogenesis. Together with EFTUD1, triggers the GTP- dependent release of EIF6 from 60S pre-ribosomes in the cytoplasm, thereby activating ribosomes for translation competence by allowing 80S ribosome assembly and facilitating EIF6 recycling to the nucleus, where it is required for 60S rRNA processing and nuclear export. Required for normal levels of protein synthesis. May play a role in cellular stress resistance. May play a role in cellular response to DNA damage. May play a role in cell prol [...] | 0.906 |
MRPL53 | SUGP1 | ENSP00000258105 | ENSP00000247001 | mitochondrial ribosomal protein L53 | SURP and G patch domain containing 1; Plays a role in pre-mRNA splicing | 0.916 |