node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ALG5 | UBC | ENSP00000239891 | ENSP00000344818 | asparagine-linked glycosylation 5, dolichyl-phosphate beta-glucosyltransferase homolog (S. cerevisiae) | ubiquitin C | 0.799 |
B3GNTL1 | UBC | ENSP00000319979 | ENSP00000344818 | UDP-GlcNAc-betaGal beta-1,3-N-acetylglucosaminyltransferase-like 1; Putative glycosyltransferase (Potential) | ubiquitin C | 0.578 |
CERS2 | ELOVL6 | ENSP00000271688 | ENSP00000304736 | ceramide synthase 2; Suppresses the growth of cancer cells. May be involved in sphingolipid synthesis | ELOVL fatty acid elongase 6; Condensing enzyme that catalyzes the synthesis of saturated and monounsaturated fatty acids. Highest activity toward C16-0 acyl-CoAs | 0.757 |
CERS2 | UBC | ENSP00000271688 | ENSP00000344818 | ceramide synthase 2; Suppresses the growth of cancer cells. May be involved in sphingolipid synthesis | ubiquitin C | 0.738 |
CYB5A | SCD | ENSP00000341625 | ENSP00000359380 | cytochrome b5 type A (microsomal); Cytochrome b5 is a membrane bound hemoprotein which function as an electron carrier for several membrane bound oxygenases | stearoyl-CoA desaturase (delta-9-desaturase) | 0.951 |
CYB5A | SCD5 | ENSP00000341625 | ENSP00000316329 | cytochrome b5 type A (microsomal); Cytochrome b5 is a membrane bound hemoprotein which function as an electron carrier for several membrane bound oxygenases | stearoyl-CoA desaturase 5; Fatty acid delta-9-desaturase that introduces a double bond in fatty acyl-coenzyme A at the delta-9 position | 0.690 |
CYB5A | UBC | ENSP00000341625 | ENSP00000344818 | cytochrome b5 type A (microsomal); Cytochrome b5 is a membrane bound hemoprotein which function as an electron carrier for several membrane bound oxygenases | ubiquitin C | 0.811 |
CYB5B | SCD | ENSP00000308430 | ENSP00000359380 | cytochrome b5 type B (outer mitochondrial membrane); Cytochrome b5 is a membrane bound hemoprotein which function as an electron carrier for several membrane bound oxygenases (By similarity) | stearoyl-CoA desaturase (delta-9-desaturase) | 0.607 |
CYB5B | SCD5 | ENSP00000308430 | ENSP00000316329 | cytochrome b5 type B (outer mitochondrial membrane); Cytochrome b5 is a membrane bound hemoprotein which function as an electron carrier for several membrane bound oxygenases (By similarity) | stearoyl-CoA desaturase 5; Fatty acid delta-9-desaturase that introduces a double bond in fatty acyl-coenzyme A at the delta-9 position | 0.605 |
CYB5B | UBC | ENSP00000308430 | ENSP00000344818 | cytochrome b5 type B (outer mitochondrial membrane); Cytochrome b5 is a membrane bound hemoprotein which function as an electron carrier for several membrane bound oxygenases (By similarity) | ubiquitin C | 0.914 |
CYB5R4 | SCD | ENSP00000358695 | ENSP00000359380 | cytochrome b5 reductase 4; NADH-cytochrome b5 reductase involved in endoplasmic reticulum stress response pathway. Plays a critical role in protecting pancreatic beta-cells against oxidant stress, possibly by protecting the cell from excess buildup of reactive oxygen species (ROS). Reduces a variety of substrates in vitro, such as cytochrome c, feericyanide and methemoglobin | stearoyl-CoA desaturase (delta-9-desaturase) | 0.681 |
CYB5R4 | SCD5 | ENSP00000358695 | ENSP00000316329 | cytochrome b5 reductase 4; NADH-cytochrome b5 reductase involved in endoplasmic reticulum stress response pathway. Plays a critical role in protecting pancreatic beta-cells against oxidant stress, possibly by protecting the cell from excess buildup of reactive oxygen species (ROS). Reduces a variety of substrates in vitro, such as cytochrome c, feericyanide and methemoglobin | stearoyl-CoA desaturase 5; Fatty acid delta-9-desaturase that introduces a double bond in fatty acyl-coenzyme A at the delta-9 position | 0.603 |
ELOVL6 | CERS2 | ENSP00000304736 | ENSP00000271688 | ELOVL fatty acid elongase 6; Condensing enzyme that catalyzes the synthesis of saturated and monounsaturated fatty acids. Highest activity toward C16-0 acyl-CoAs | ceramide synthase 2; Suppresses the growth of cancer cells. May be involved in sphingolipid synthesis | 0.757 |
ELOVL6 | OXSM | ENSP00000304736 | ENSP00000280701 | ELOVL fatty acid elongase 6; Condensing enzyme that catalyzes the synthesis of saturated and monounsaturated fatty acids. Highest activity toward C16-0 acyl-CoAs | 3-oxoacyl-ACP synthase, mitochondrial; May play a role in the biosynthesis of lipoic acid as well as longer chain fatty acids required for optimal mitochondrial function | 0.834 |
ELOVL6 | SCD | ENSP00000304736 | ENSP00000359380 | ELOVL fatty acid elongase 6; Condensing enzyme that catalyzes the synthesis of saturated and monounsaturated fatty acids. Highest activity toward C16-0 acyl-CoAs | stearoyl-CoA desaturase (delta-9-desaturase) | 0.838 |
ELOVL6 | SCD5 | ENSP00000304736 | ENSP00000316329 | ELOVL fatty acid elongase 6; Condensing enzyme that catalyzes the synthesis of saturated and monounsaturated fatty acids. Highest activity toward C16-0 acyl-CoAs | stearoyl-CoA desaturase 5; Fatty acid delta-9-desaturase that introduces a double bond in fatty acyl-coenzyme A at the delta-9 position | 0.723 |
ELOVL6 | SREBF2 | ENSP00000304736 | ENSP00000354476 | ELOVL fatty acid elongase 6; Condensing enzyme that catalyzes the synthesis of saturated and monounsaturated fatty acids. Highest activity toward C16-0 acyl-CoAs | sterol regulatory element binding transcription factor 2; Transcriptional activator required for lipid homeostasis. Regulates transcription of the LDL receptor gene as well as the cholesterol and to a lesser degree the fatty acid synthesis pathway (By similarity). Binds the sterol regulatory element 1 (SRE-1) (5’-ATCACCCCAC-3’) found in the flanking region of the LDRL and HMG-CoA synthase genes | 0.933 |
EMC1 | UBC | ENSP00000420608 | ENSP00000344818 | ER membrane protein complex subunit 1 | ubiquitin C | 0.917 |
OXSM | ELOVL6 | ENSP00000280701 | ENSP00000304736 | 3-oxoacyl-ACP synthase, mitochondrial; May play a role in the biosynthesis of lipoic acid as well as longer chain fatty acids required for optimal mitochondrial function | ELOVL fatty acid elongase 6; Condensing enzyme that catalyzes the synthesis of saturated and monounsaturated fatty acids. Highest activity toward C16-0 acyl-CoAs | 0.834 |
SCD | CYB5A | ENSP00000359380 | ENSP00000341625 | stearoyl-CoA desaturase (delta-9-desaturase) | cytochrome b5 type A (microsomal); Cytochrome b5 is a membrane bound hemoprotein which function as an electron carrier for several membrane bound oxygenases | 0.951 |