node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
BAMBI | BMP2 | ENSP00000364683 | ENSP00000368104 | BMP and activin membrane-bound inhibitor homolog (Xenopus laevis); Negatively regulates TGF-beta signaling (By similarity) | bone morphogenetic protein 2; Induces cartilage and bone formation | 0.929 |
BAMBI | BMP4 | ENSP00000364683 | ENSP00000245451 | BMP and activin membrane-bound inhibitor homolog (Xenopus laevis); Negatively regulates TGF-beta signaling (By similarity) | bone morphogenetic protein 4; Induces cartilage and bone formation. Also act in mesoderm induction, tooth development, limb formation and fracture repair. Acts in concert with PTHLH/PTHRP to stimulate ductal outgrowth during embryonic mammary development and to inhibit hair follicle induction (By similarity) | 0.944 |
BAMBI | BMP6 | ENSP00000364683 | ENSP00000283147 | BMP and activin membrane-bound inhibitor homolog (Xenopus laevis); Negatively regulates TGF-beta signaling (By similarity) | bone morphogenetic protein 6; Induces cartilage and bone formation | 0.928 |
BAMBI | BMP7 | ENSP00000364683 | ENSP00000379204 | BMP and activin membrane-bound inhibitor homolog (Xenopus laevis); Negatively regulates TGF-beta signaling (By similarity) | bone morphogenetic protein 7; Induces cartilage and bone formation. May be the osteoinductive factor responsible for the phenomenon of epithelial osteogenesis. Plays a role in calcium regulation and bone homeostasis | 0.988 |
BAMBI | BMPR1A | ENSP00000364683 | ENSP00000224764 | BMP and activin membrane-bound inhibitor homolog (Xenopus laevis); Negatively regulates TGF-beta signaling (By similarity) | bone morphogenetic protein receptor, type IA; On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for BMP-2 and BMP-4 | 0.968 |
BAMBI | BMPR1B | ENSP00000364683 | ENSP00000264568 | BMP and activin membrane-bound inhibitor homolog (Xenopus laevis); Negatively regulates TGF-beta signaling (By similarity) | bone morphogenetic protein receptor, type IB; On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for BMP7/OP-1 and GDF5 | 0.967 |
BAMBI | BMPR2 | ENSP00000364683 | ENSP00000363708 | BMP and activin membrane-bound inhibitor homolog (Xenopus laevis); Negatively regulates TGF-beta signaling (By similarity) | bone morphogenetic protein receptor, type II (serine/threonine kinase); On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Binds to BMP-7, BMP-2 and, less efficiently, BMP-4. Binding is weak but enhanced by the presence of type I receptors for BMPs | 0.933 |
BAMBI | RGMA | ENSP00000364683 | ENSP00000452126 | BMP and activin membrane-bound inhibitor homolog (Xenopus laevis); Negatively regulates TGF-beta signaling (By similarity) | RGM domain family, member A; Member of the repulsive guidance molecule (RGM) family that performs several functions in the developing and adult nervous system. Regulates cephalic neural tube closure, inhibits neurite outgrowth and cortical neuron branching, and the formation of mature synapses. Binding to its receptor NEO1/neogenin induces activation of RHOA-ROCK1/Rho-kinase signaling pathway through UNC5B-ARHGEF12/LARG-PTK2/FAK1 cascade, leading to collapse of the neuronal growth cone and neurite outgrowth inhibition. Furthermore, RGMA binding to NEO1/neogenin leads to HRAS inactivati [...] | 0.901 |
BAMBI | RGMB | ENSP00000364683 | ENSP00000308219 | BMP and activin membrane-bound inhibitor homolog (Xenopus laevis); Negatively regulates TGF-beta signaling (By similarity) | RGM domain family, member B; Member of the repulsive guidance molecule (RGM) family that contributes to the patterning of the developing nervous system (By similarity). Acts as a bone morphogenetic protein (BMP) coreceptor that potentiates BMP signaling (By similarity). Promotes neuronal adhesion (By similarity). May inhibit neurite outgrowth | 0.914 |
BAMBI | SOSTDC1 | ENSP00000364683 | ENSP00000304930 | BMP and activin membrane-bound inhibitor homolog (Xenopus laevis); Negatively regulates TGF-beta signaling (By similarity) | sclerostin domain containing 1; May be involved in the onset of endometrial receptivity for implantation/sensitization for the decidual cell reaction Enhances Wnt signaling and inhibits TGF-beta signaling (By similarity). Directly antagonizes activity of BMP2, BMP4, BMP6 and BMP7 in a dose-dependent manner | 0.908 |
BMP2 | BAMBI | ENSP00000368104 | ENSP00000364683 | bone morphogenetic protein 2; Induces cartilage and bone formation | BMP and activin membrane-bound inhibitor homolog (Xenopus laevis); Negatively regulates TGF-beta signaling (By similarity) | 0.929 |
BMP2 | BMP4 | ENSP00000368104 | ENSP00000245451 | bone morphogenetic protein 2; Induces cartilage and bone formation | bone morphogenetic protein 4; Induces cartilage and bone formation. Also act in mesoderm induction, tooth development, limb formation and fracture repair. Acts in concert with PTHLH/PTHRP to stimulate ductal outgrowth during embryonic mammary development and to inhibit hair follicle induction (By similarity) | 0.903 |
BMP2 | BMP6 | ENSP00000368104 | ENSP00000283147 | bone morphogenetic protein 2; Induces cartilage and bone formation | bone morphogenetic protein 6; Induces cartilage and bone formation | 0.709 |
BMP2 | BMP7 | ENSP00000368104 | ENSP00000379204 | bone morphogenetic protein 2; Induces cartilage and bone formation | bone morphogenetic protein 7; Induces cartilage and bone formation. May be the osteoinductive factor responsible for the phenomenon of epithelial osteogenesis. Plays a role in calcium regulation and bone homeostasis | 0.968 |
BMP2 | BMPR1A | ENSP00000368104 | ENSP00000224764 | bone morphogenetic protein 2; Induces cartilage and bone formation | bone morphogenetic protein receptor, type IA; On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for BMP-2 and BMP-4 | 0.999 |
BMP2 | BMPR1B | ENSP00000368104 | ENSP00000264568 | bone morphogenetic protein 2; Induces cartilage and bone formation | bone morphogenetic protein receptor, type IB; On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for BMP7/OP-1 and GDF5 | 0.999 |
BMP2 | BMPR2 | ENSP00000368104 | ENSP00000363708 | bone morphogenetic protein 2; Induces cartilage and bone formation | bone morphogenetic protein receptor, type II (serine/threonine kinase); On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Binds to BMP-7, BMP-2 and, less efficiently, BMP-4. Binding is weak but enhanced by the presence of type I receptors for BMPs | 0.998 |
BMP2 | RGMA | ENSP00000368104 | ENSP00000452126 | bone morphogenetic protein 2; Induces cartilage and bone formation | RGM domain family, member A; Member of the repulsive guidance molecule (RGM) family that performs several functions in the developing and adult nervous system. Regulates cephalic neural tube closure, inhibits neurite outgrowth and cortical neuron branching, and the formation of mature synapses. Binding to its receptor NEO1/neogenin induces activation of RHOA-ROCK1/Rho-kinase signaling pathway through UNC5B-ARHGEF12/LARG-PTK2/FAK1 cascade, leading to collapse of the neuronal growth cone and neurite outgrowth inhibition. Furthermore, RGMA binding to NEO1/neogenin leads to HRAS inactivati [...] | 0.918 |
BMP2 | RGMB | ENSP00000368104 | ENSP00000308219 | bone morphogenetic protein 2; Induces cartilage and bone formation | RGM domain family, member B; Member of the repulsive guidance molecule (RGM) family that contributes to the patterning of the developing nervous system (By similarity). Acts as a bone morphogenetic protein (BMP) coreceptor that potentiates BMP signaling (By similarity). Promotes neuronal adhesion (By similarity). May inhibit neurite outgrowth | 0.937 |
BMP2 | SOSTDC1 | ENSP00000368104 | ENSP00000304930 | bone morphogenetic protein 2; Induces cartilage and bone formation | sclerostin domain containing 1; May be involved in the onset of endometrial receptivity for implantation/sensitization for the decidual cell reaction Enhances Wnt signaling and inhibits TGF-beta signaling (By similarity). Directly antagonizes activity of BMP2, BMP4, BMP6 and BMP7 in a dose-dependent manner | 0.985 |