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STRINGSTRING
ARFRP1 ARFRP1 TBC1D22B TBC1D22B ENSG00000254995 ENSG00000254995 ARL13B ARL13B TBC1D22A TBC1D22A STX16 STX16 GOLT1B GOLT1B SYS1 SYS1 KIAA1432 KIAA1432 GOLT1A GOLT1A GOSR1 GOSR1 RER1 RER1 COG6 COG6 COG8 COG8 COG3 COG3 UBC UBC COG1 COG1 COG4 COG4 COG7 COG7 VPS51 VPS51 COG2 COG2 TRAPPC8 TRAPPC8 GOLGA3 GOLGA3 COG5 COG5 IST1 IST1 MYEF2 MYEF2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small protein node
small nodes:
protein of unknown 3D structure
large protein node
large nodes:
some 3D structure is known or predicted
Node Color
colored protein node
colored nodes:
query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
database edge
from curated databases
experiment edge
experimentally determined
Predicted Interactions
neighborhood edge
gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
Others
textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
Your Input:
GOLGA3golgin A3; Golgi auto-antigen; probably involved in maintaining Golgi structure (1498 aa)
GOSR1golgi SNAP receptor complex member 1; Involved in transport from the ER to the Golgi apparatus as well as in intra-Golgi transport. It belongs to a super-family of proteins called t-SNAREs or soluble NSF (N-ethylmaleimide- sensitive factor) attachment protein receptor. May play a protective role against hydrogen peroxide induced cytotoxicity under glutathione depleted conditions in neuronal cells by regulating the intracellular ROS levels via inhibition of p38 MAPK (MAPK11, MAPK12, MAPK13 and MAPK14). Participates in docking and fusion stage of ER to cis-Golgi transport. Plays an impor [...] (250 aa)
GOLT1Bgolgi transport 1B; May be involved in fusion of ER-derived transport vesicles with the Golgi complex (138 aa)
SYS1SYS1 Golgi-localized integral membrane protein homolog (S. cerevisiae); Involved in protein trafficking. May serve as a receptor for ARFRP1 (156 aa)
COG3component of oligomeric golgi complex 3; Involved in ER-Golgi transport (828 aa)
VPS51vacuolar protein sorting 51 homolog (S. cerevisiae); Acts as component of the GARP complex that is involved in retrograde transport from early and late endosomes to the trans-Golgi networkl (TGN). The GARP complex is required for the maintenance of protein retrieval from endosomes to the TGN, acid hydrolase sorting, lysosome function, endosomal cholesterol traffic and autophagy. VPS51 participates in retrograde transport of acid hydrolase receptors, likely by promoting tethering and SNARE-dependent fusion of endosome-derived carriers to the TGN (782 aa)
TRAPPC8trafficking protein particle complex 8; May be involved in endoplasmic reticulum to Golgi apparatus trafficking at a very early stage (1435 aa)
COG5component of oligomeric golgi complex 5; Required for normal Golgi function (By similarity) (860 aa)
COG1component of oligomeric golgi complex 1; Required for normal Golgi function (By similarity) (980 aa)
RER1RER1 retention in endoplasmic reticulum 1 homolog (S. cerevisiae); Involved in the retrieval of endoplasmic reticulum membrane proteins from the early Golgi compartment (By similarity) (196 aa)
COG7component of oligomeric golgi complex 7; Required for normal Golgi function (By similarity) (770 aa)
COG8component of oligomeric golgi complex 8; Required for normal Golgi function (By similarity) (612 aa)
GOLT1Agolgi transport 1A; May be involved in fusion of ER-derived transport vesicles with the Golgi complex (132 aa)
COG4component of oligomeric golgi complex 4; Required for normal Golgi function. Plays a role in SNARE-pin assembly and Golgi-to-ER retrograde transport via its interaction with SCFD1 (789 aa)
MYEF2myelin expression factor 2 (600 aa)
ARFRP1ADP-ribosylation factor related protein 1; Possibly involved in plasma membrane-related signaling events (201 aa)
IST1increased sodium tolerance 1 homolog (yeast); Proposed to be involved in specific functions of the ESCRT machinery. Is required for efficient abscission during cytokinesis, but not for HIV-1 budding. The involvement in the MVB pathway is not established. Involved in recruiting VPS4A and/or VPS4B to the midbody of dividing cells (360 aa)
TBC1D22ATBC1 domain family, member 22A (517 aa)
UBCubiquitin C (685 aa)
COG2component of oligomeric golgi complex 2; Required for normal Golgi morphology and function (738 aa)
STX16syntaxin 16 (325 aa)
TBC1D22BTBC1 domain family, member 22B; May act as a GTPase-activating protein for Rab family protein(s) (By similarity) (505 aa)
ARL13BADP-ribosylation factor-like 13B (428 aa)
COG6component of oligomeric golgi complex 6; Required for normal Golgi function (By similarity) (657 aa)
KIAA1432KIAA1432 (1423 aa)
ENSG00000254995STX16-NPEPL1 readthrough (non-protein coding) (382 aa)
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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