Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small nodes:
protein of unknown 3D structure
protein of unknown 3D structure
large nodes:
some 3D structure is known or predicted
some 3D structure is known or predicted
Node Color
colored nodes:
query proteins and first shell of interactors
query proteins and first shell of interactors
white nodes:
second shell of interactors
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Your Input:
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 | FUT5 | fucosyltransferase 5 (alpha (1,3) fucosyltransferase); May catalyze alpha-1,3 glycosidic linkages involved in the expression of VIM-2, Lewis X/SSEA-1 and sialyl Lewis X antigens (374 aa) | ||
 | OGN | osteoglycin; Induces bone formation in conjunction with TGF-beta-1 or TGF-beta-2 (298 aa) | ||
 | GCNT2 | glucosaminyl (N-acetyl) transferase 2, I-branching enzyme (I blood group); Branching enzyme that converts linear into branched poly-N-acetyllactosaminoglycans. Introduces the blood group I antigen during embryonic development. It is closely associated with the development and maturation of erythroid cells. The expression of the blood group I antigen in erythrocytes is determined by isoform C (402 aa) | ||
 | KERA | keratocan; May be important in developing and maintaining corneal transparency and for the structure of the stromal matrix (352 aa) | ||
 | FUT6 | fucosyltransferase 6 (alpha (1,3) fucosyltransferase); Enzyme involved in the biosynthesis of the E-Selectin ligand, sialyl-Lewis X. Catalyzes the transfer of fucose from GDP- beta-fucose to alpha-2,3 sialylated substrates (359 aa) | ||
 | FUT9 | fucosyltransferase 9 (alpha (1,3) fucosyltransferase); Transfers a fucose to lacto-N-neotetraose but not to either alpha2,3-sialyl lacto-N-neotetraose or lacto-N-tetraose. Can catalyze the last step in the biosynthesis of Lewis antigen, the addition of a fucose to precursor polysaccharides (359 aa) | ||
 | B3GNT2 | UDP-GlcNAc-betaGal beta-1,3-N-acetylglucosaminyltransferase 2; Catalyzes the initiation and elongation of poly-N- acetyllactosamine chains (397 aa) | ||
 | FUT1 | fucosyltransferase 1 (galactoside 2-alpha-L-fucosyltransferase, H blood group); Creates a soluble precursor oligosaccharide FuC-alpha ((1,2)Galbeta-) called the H antigen which is an essential substrate for the final step in the soluble A and B antigen synthesis pathway. H and Se enzymes fucosylate the same acceptor substrates but exhibit different Km values (365 aa) | ||
 | B3GNT4 | UDP-GlcNAc-betaGal beta-1,3-N-acetylglucosaminyltransferase 4; Has a beta-1,3-N-acetylglucosaminyltransferase activity for type 2 oligosaccharides (378 aa) | ||
 | B4GALT3 | UDP-Gal-betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 3; Responsible for the synthesis of complex-type N-linked oligosaccharides in many glycoproteins as well as the carbohydrate moieties of glycolipids (393 aa) | ||
 | B3GNT3 | UDP-GlcNAc-betaGal beta-1,3-N-acetylglucosaminyltransferase 3; Has a beta-1,3-N-acetylglucosaminyltransferase activity for type 2 oligosaccharides (372 aa) | ||
 | MUC3A | mucin 3A, cell surface associated; Major glycoprotein component of a variety of mucus gels. Thought to provide a protective, lubricating barrier against particles and infectious agents at mucosal surfaces (By similarity) (876 aa) | ||
 | PRELP | proline/arginine-rich end leucine-rich repeat protein; May anchor basement membranes to the underlying connective tissue (By similarity) (382 aa) | ||
 | FMOD | fibromodulin; Affects the rate of fibrils formation. May have a primary role in collagen fibrillogenesis (By similarity) (376 aa) | ||
 | B4GALT4 | UDP-Gal-betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 4; Responsible for the synthesis of complex-type N-linked oligosaccharides in many glycoproteins as well as the carbohydrate moieties of glycolipids (344 aa) | ||
 | MUC21 | mucin 21, cell surface associated (566 aa) | ||
 | B4GALT1 | UDP-Gal-betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 1 (398 aa) | ||
 | FUT2 | fucosyltransferase 2 (secretor status included); Creates a soluble precursor oligosaccharide FuC-alpha ((1,2)Galbeta-) called the H antigen which is an essential substrate for the final step in the soluble A and B antigen synthesis pathway. H and Se enzymes fucosylate the same acceptor substrates but exhibit different Km values (343 aa) | ||
 | MUC16 | mucin 16, cell surface associated; Thought to provide a protective, lubricating barrier against particles and infectious agents at mucosal surfaces (By similarity) (14507 aa) | ||
 | ACAN | aggrecan; This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region (2530 aa) | ||
 | MUC19 | mucin 19, oligomeric; May function in ocular mucus homeostasis (1640 aa) | ||
 | MUC20 | mucin 20, cell surface associated; May regulate MET signaling cascade. Seems to decrease hepatocyte growth factor (HGF)-induced transient MAPK activation. Blocks GRB2 recruitment to MET thus suppressing the GRB2-RAS pathway. Inhibits HGF-induced proliferation of MMP1 and MMP9 expression (723 aa) | ||
 | MUC6 | mucin 6, oligomeric mucus/gel-forming; May provide a mechanism for modulation of the composition of the protective mucus layer related to acid secretion or the presence of bacteria and noxious agents in the lumen. Plays an important role in the cytoprotection of epithelial surfaces and are used as tumor markers in a variety of cancers. May play a role in epithelial organogenesis (2439 aa) | ||
 | MUC2 | mucin 2, oligomeric mucus/gel-forming; Coats the epithelia of the intestines, airways, and other mucus membrane-containing organs. Thought to provide a protective, lubricating barrier against particles and infectious agents at mucosal surfaces. Major constituent of both the inner and outer mucus layers of the colon and may play a role in excluding bacteria from the inner mucus layer (2817 aa) | ||
 | MUC15 | mucin 15, cell surface associated; May play a role in the cell adhesion to the extracellular matrix (361 aa) | ||
 | MUC4 | mucin 4, cell surface associated (5412 aa) | ||
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
Other names: H. sapiens, Homo, Homo sapiens, human, man
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