Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small nodes:
protein of unknown 3D structure
protein of unknown 3D structure
large nodes:
some 3D structure is known or predicted
some 3D structure is known or predicted
Node Color
colored nodes:
query proteins and first shell of interactors
query proteins and first shell of interactors
white nodes:
second shell of interactors
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Your Input:
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 | DLD | dihydrolipoamide dehydrogenase; Lipoamide dehydrogenase is a component of the glycine cleavage system as well as of the alpha-ketoacid dehydrogenase complexes. Involved in the hyperactivation of spermatazoa during capacitation and in the spermatazoal acrosome reaction (509 aa) | ||
 | GSR | glutathione reductase; Maintains high levels of reduced glutathione in the cytosol (522 aa) | ||
 | TPI1 | triosephosphate isomerase 1 (286 aa) | ||
 | CTSD | cathepsin D; Acid protease active in intracellular protein breakdown. Involved in the pathogenesis of several diseases such as breast cancer and possibly Alzheimer disease (412 aa) | ||
 | DYNLL1 | dynein, light chain, LC8-type 1; Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in changing or maintaining the spatial distribution of cytoskeletal structures (89 aa) | ||
 | NAPSA | napsin A aspartic peptidase; May be involved in processing of pneumocyte surfactant precursors (420 aa) | ||
 | PRDX5 | peroxiredoxin 5; Reduces hydrogen peroxide and alkyl hydroperoxides with reducing equivalents provided through the thioredoxin system. Involved in intracellular redox signaling (214 aa) | ||
 | REN | renin; Renin is a highly specific endopeptidase, whose only known function is to generate angiotensin I from angiotensinogen in the plasma, initiating a cascade of reactions that produce an elevation of blood pressure and increased sodium retention by the kidney (406 aa) | ||
 | KIAA1149 | beta-secretase 1 isoform E (401 aa) | ||
 | NXNL1 | nucleoredoxin-like 1; May play a role in cone cell viability, slowing down cone degeneration, does not seem to play a role in degenerating rods (By similarity) (212 aa) | ||
 | PGA5 | pepsinogen 5, group I (pepsinogen A); Shows particularly broad specificity; although bonds involving phenylalanine and leucine are preferred, many others are also cleaved to some extent (388 aa) | ||
 | MSRA | methionine sulfoxide reductase A; Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (235 aa) | ||
 | BACE1 | beta-site APP-cleaving enzyme 1; Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves at the N-terminus of the A-beta peptide sequence, between residues 671 and 672 of APP, leads to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase (501 aa) | ||
 | PGA3 | pepsinogen 3, group I (pepsinogen A); Shows particularly broad specificity; although bonds involving phenylalanine and leucine are preferred, many others are also cleaved to some extent (388 aa) | ||
 | BACE2 | beta-site APP-cleaving enzyme 2; Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves APP, between residues 690 and 691, leading to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C- terminal fragment which is later released by gamma-secretase. It has also been shown that it can cleave APP between residues 671 and 672 (518 aa) | ||
 | CTSE | cathepsin E (396 aa) | ||
 | LGSN | lengsin, lens protein with glutamine synthetase domain; May act as a component of the cytoskeleton or as a chaperone for the reorganization of intermediate filament proteins during terminal differentiation in the lens. Does not seem to have enzymatic activity (By similarity) (509 aa) | ||
 | PGC | progastricsin (pepsinogen C); Hydrolyzes a variety of proteins (388 aa) | ||
 | MAPRE1 | microtubule-associated protein, RP/EB family, member 1; Binds to the plus end of microtubules and regulates the dynamics of the microtubule cytoskeleton. Promotes cytoplasmic microtubule nucleation and elongation. May be involved in spindle function by stabilizing microtubules and anchoring them at centrosomes. May play a role in cell migration (268 aa) | ||
 | PGA4 | pepsinogen 4, group I (pepsinogen A); Shows particularly broad specificity; although bonds involving phenylalanine and leucine are preferred, many others are also cleaved to some extent (388 aa) | ||
 | TXNRD2 | thioredoxin reductase 2 (524 aa) | ||
 | CEBPD | CCAAT/enhancer binding protein (C/EBP), delta; C/EBP is a DNA-binding protein that recognizes two different motifs- the CCAAT homology common to many promoters and the enhanced core homology common to many enhancers. Important transcriptional activator in the regulation of genes involved in immune and inflammatory responses, may play an important role in the regulation of the several genes associated with activation and/or differentiation of macrophages (269 aa) | ||
 | ZNF385C | zinc finger protein 385C (499 aa) | ||
 | ENSG00000250644 | Uncharacterized protein (379 aa) | ||
 | TXNRD3 | thioredoxin reductase 3; Displays thioredoxin reductase, glutaredoxin and glutathione reductase activities. Catalyzes disulfide bond isomerization. Promotes disulfide bond formation between GPX4 and various sperm proteins and may play a role in sperm maturation by promoting formation of sperm structural components (By similarity) (698 aa) | ||
 | TXNRD1 | thioredoxin reductase 1 (649 aa) | ||
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
Other names: H. sapiens, Homo, Homo sapiens, human, man
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