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USP32 USP32 USP10 USP10 MARC1 MARC1 PAN2 PAN2 MRPS9 MRPS9 UBC UBC ICT1 ICT1 MRPL55 MRPL55 MRPL39 MRPL39 DLST DLST MRPL15 MRPL15 TSR1 TSR1 MRPL32 MRPL32 MRPL11 MRPL11 MRPL24 MRPL24 MRPL13 MRPL13 MRPL37 MRPL37 MRPL3 MRPL3 MRPL38 MRPL38 MRPL49 MRPL49 MRPL40 MRPL40 MRPL19 MRPL19 MRPL44 MRPL44 MRPL9 MRPL9 MRPL52 MRPL52 MRPL14 MRPL14
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small protein node
small nodes:
protein of unknown 3D structure
large protein node
large nodes:
some 3D structure is known or predicted
Node Color
colored protein node
colored nodes:
query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
database edge
from curated databases
experiment edge
experimentally determined
Predicted Interactions
neighborhood edge
gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
Others
textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
Your Input:
USP10ubiquitin specific peptidase 10; Hydrolase that can remove conjugated ubiquitin from target proteins such as p53/TP53, BECN1, SNX3 and CFTR. Acts as an essential regulator of p53/TP53 stability- in unstressed cells, specifically deubiquitinates p53/TP53 in the cytoplasm, leading to counteract MDM2 action and stabilize p53/TP53. Following DNA damage, translocates to the nucleus and deubiquitinates p53/TP53, leading to regulate the p53/TP53-dependent DNA damage response. Component of a regulatory loop that controls autophagy and p53/TP53 levels- mediates deubiquitination of BECN1, a key [...] (798 aa)
MRPL32mitochondrial ribosomal protein L32 (188 aa)
MRPL44mitochondrial ribosomal protein L44; Component of the 39S subunit of mitochondrial ribosome (332 aa)
MRPS9mitochondrial ribosomal protein S9 (396 aa)
MRPL15mitochondrial ribosomal protein L15 (296 aa)
MRPL3mitochondrial ribosomal protein L3 (348 aa)
MRPL49mitochondrial ribosomal protein L49 (166 aa)
USP32ubiquitin specific peptidase 32 (1604 aa)
TSR1TSR1, 20S rRNA accumulation, homolog (S. cerevisiae); Required during maturation of the 40S ribosomal subunit in the nucleolus (By similarity) (804 aa)
ICT1immature colon carcinoma transcript 1; Essential peptidyl-tRNA hydrolase component of the mitochondrial large ribosomal subunit. Acts as a codon-independent translation release factor that has lost all stop codon specificity and directs the termination of translation in mitochondrion, possibly in case of abortive elongation. May be involved in the hydrolysis of peptidyl-tRNAs that have been prematurely terminated and thus in the recycling of stalled mitochondrial ribosomes (206 aa)
MRPL39mitochondrial ribosomal protein L39 (353 aa)
MRPL13mitochondrial ribosomal protein L13 (178 aa)
MRPL38mitochondrial ribosomal protein L38 (380 aa)
MRPL11mitochondrial ribosomal protein L11 (192 aa)
MRPL40mitochondrial ribosomal protein L40 (206 aa)
DLSTdihydrolipoamide S-succinyltransferase (E2 component of 2-oxo-glutarate complex); The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2). It contains multiple copies of 3 enzymatic components- 2-oxoglutarate dehydrogenase (E1), dihydrolipoamide succinyltransferase (E2) and lipoamide dehydrogenase (E3) (453 aa)
UBCubiquitin C (685 aa)
MRPL52mitochondrial ribosomal protein L52 (123 aa)
MRPL37mitochondrial ribosomal protein L37 (423 aa)
MRPL24mitochondrial ribosomal protein L24 (216 aa)
MRPL55mitochondrial ribosomal protein L55 (164 aa)
MARC1mitochondrial amidoxime reducing component 1 (337 aa)
MRPL9mitochondrial ribosomal protein L9 (267 aa)
MRPL14mitochondrial ribosomal protein L14; Forms part of 2 intersubunit bridges in the assembled ribosome. Upon binding to MALSU1 intersubunit bridge formation is blocked, preventing ribosome formation and repressing translation (Probable) (145 aa)
MRPL19mitochondrial ribosomal protein L19 (292 aa)
PAN2PAN2 poly(A) specific ribonuclease subunit homolog (S. cerevisiae); Functions in cytoplasmic mRNA decay. As part of the Pan nuclease complex, shortens poly(A) tails of RNA when the poly(A) stretch is bound by polyadenylate-binding protein (1202 aa)
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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