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SYK SYK ZAP70 ZAP70 ALDH3A1 ALDH3A1 ENSG00000255767 ENSG00000255767 ALDH1L2 ALDH1L2 ALDH3A2 ALDH3A2 AKR1B1 AKR1B1 SHMT1 SHMT1 GAPDH GAPDH ENO1 ENO1 ALDH1B1 ALDH1B1 ENO3 ENO3 ALDH1A2 ALDH1A2 ENSG00000269469 ENSG00000269469 GAPDHS GAPDHS ENO2 ENO2 ENO4 ENO4 ALDH1A3 ALDH1A3 PGK2 PGK2 ALDH3B2 ALDH3B2 PGK1 PGK1 ALDOC ALDOC PNMAL2 PNMAL2 HDHD1 HDHD1 PFKFB1 PFKFB1 PFKFB4 PFKFB4
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small protein node
small nodes:
protein of unknown 3D structure
large protein node
large nodes:
some 3D structure is known or predicted
Node Color
colored protein node
colored nodes:
query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
database edge
from curated databases
experiment edge
experimentally determined
Predicted Interactions
neighborhood edge
gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
Others
textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
Your Input:
GAPDHSglyceraldehyde-3-phosphate dehydrogenase, spermatogenic; May play an important role in regulating the switch between different pathways for energy production during spermiogenesis and in the spermatozoon. Required for sperm motility and male fertility (By similarity) (408 aa)
ALDH3A1aldehyde dehydrogenase 3 family, member A1; ALDHs play a major role in the detoxification of alcohol-derived acetaldehyde. They are involved in the metabolism of corticosteroids, biogenic amines, neurotransmitters, and lipid peroxidation. This protein preferentially oxidizes aromatic aldehyde substrates. It may play a role in the oxidation of toxic aldehydes (453 aa)
ALDOCaldolase C, fructose-bisphosphate (364 aa)
GAPDHglyceraldehyde-3-phosphate dehydrogenase; Has both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities, thereby playing a role in glycolysis and nuclear functions, respectively. Participates in nuclear events including transcription, RNA transport, DNA replication and apoptosis. Nuclear functions are probably due to the nitrosylase activity that mediates cysteine S-nitrosylation of nuclear target proteins such as SIRT1, HDAC2 and PRKDC. Modulates the organization and assembly of the cytoskeleton. Facilitates the CHP1-dependent microtubule and membrane associations throu [...] (335 aa)
ENO2enolase 2 (gamma, neuronal); Has neurotrophic and neuroprotective properties on a broad spectrum of central nervous system (CNS) neurons. Binds, in a calcium-dependent manner, to cultured neocortical neurons and promotes cell survival (By similarity) (434 aa)
PFKFB46-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4; Synthesis and degradation of fructose 2,6-bisphosphate (469 aa)
ENO1enolase 1, (alpha) (434 aa)
ALDH1A2aldehyde dehydrogenase 1 family, member A2; Recognizes as substrates free retinal and cellular retinol-binding protein-bound retinal. Does metabolize octanal and decanal but does not metabolize citral, benzaldehyde, acetaldehyde and propanal efficiently (By similarity) (518 aa)
ALDH3B2aldehyde dehydrogenase 3 family, member B2 (385 aa)
ALDH1L2aldehyde dehydrogenase 1 family, member L2 (923 aa)
ZAP70zeta-chain (TCR) associated protein kinase 70kDa; Tyrosine kinase that plays an essential role in regulation of the adaptive immune response. Regulates motility, adhesion and cytokine expression of mature T-cells, as well as thymocyte development. Contributes also to the development and activation of primary B-lymphocytes. When antigen presenting cells (APC) activate T-cell receptor (TCR), a serie of phosphorylations lead to the recruitment of ZAP70 to the doubly phosphorylated TCR component CD247/CD3Z through ITAM motif at the plasma membrane. This recruitment serves to localization t [...] (619 aa)
AKR1B1aldo-keto reductase family 1, member B1 (aldose reductase); Catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols with a broad range of catalytic efficiencies (316 aa)
PGK2phosphoglycerate kinase 2 (417 aa)
SHMT1serine hydroxymethyltransferase 1 (soluble); Interconversion of serine and glycine (By similarity) (483 aa)
ENO3enolase 3 (beta, muscle); Appears to have a function in striated muscle development and regeneration (434 aa)
ALDH1A3aldehyde dehydrogenase 1 family, member A3; Recognizes as substrates free retinal and cellular retinol-binding protein-bound retinal. Seems to be the key enzyme in the formation of an RA gradient along the dorso-ventral axis during the early eye development and also in the development of the olfactory system (By similarity) (512 aa)
ENO4enolase family member 4 (628 aa)
ALDH3A2aldehyde dehydrogenase 3 family, member A2; Catalyzes the oxidation of long-chain aliphatic aldehydes to fatty acids. Active on a variety of saturated and unsaturated aliphatic aldehydes between 6 and 24 carbons in length. Responsible for conversion of the sphingosine 1-phosphate (S1P) degradation product hexadecenal to hexadecenoic acid (508 aa)
PGK1phosphoglycerate kinase 1; In addition to its role as a glycolytic enzyme, it seems that PGK-1 acts as a polymerase alpha cofactor protein (primer recognition protein) (417 aa)
PFKFB16-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1; Synthesis and degradation of fructose 2,6-bisphosphate (471 aa)
SYKspleen tyrosine kinase; Non-receptor tyrosine kinase which mediates signal transduction downstream of a variety of transmembrane receptors including classical immunoreceptors like the B-cell receptor (BCR). Regulates several biological processes including innate and adaptive immunity, cell adhesion, osteoclast maturation, platelet activation and vascular development. Assembles into signaling complexes with activated receptors at the plasma membrane via interaction between its SH2 domains and the receptor tyrosine- phosphorylated ITAM domains. The association with the receptor can also [...] (635 aa)
ALDH1B1aldehyde dehydrogenase 1 family, member B1; ALDHs play a major role in the detoxification of alcohol-derived acetaldehyde. They are involved in the metabolism of corticosteroids, biogenic amines, neurotransmitters, and lipid peroxidation (517 aa)
HDHD1haloacid dehalogenase-like hydrolase domain containing 1; Dephosphorylates pseudouridine 5’-phosphate, a potential intermediate in rRNA degradation. Pseudouridine is then excreted intact in urine (251 aa)
ENSG00000255767Uncharacterized protein (34 aa)
ENSG00000269469Uncharacterized protein (72 aa)
PNMAL2paraneoplastic Ma antigen family-like 2 (635 aa)
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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