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MIF4GD MIF4GD RPTN RPTN DRAP1 DRAP1 XPO5 XPO5 GLE1 GLE1 XPO6 XPO6 TPR TPR SPTBN1 SPTBN1 DDX19A DDX19A POLDIP3 POLDIP3 SAC3D1 SAC3D1 SPTAN1 SPTAN1 MCM3AP MCM3AP ZC3H14 ZC3H14 NXF2 NXF2 UBC UBC NXF2B NXF2B NXF3 NXF3 NXF1 NXF1 NXF5 NXF5 FUBP1 FUBP1 XPO1 XPO1 ALYREF ALYREF PABPC1 PABPC1 PABPC1L2B PABPC1L2B PABPC1L PABPC1L
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small protein node
small nodes:
protein of unknown 3D structure
large protein node
large nodes:
some 3D structure is known or predicted
Node Color
colored protein node
colored nodes:
query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
database edge
from curated databases
experiment edge
experimentally determined
Predicted Interactions
neighborhood edge
gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
Others
textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
Your Input:
PABPC1Lpoly(A) binding protein, cytoplasmic 1-like (614 aa)
MIF4GDMIF4G domain containing; Functions in replication-dependent translation of histone mRNAs which differ from other eukaryotic mRNAs in that they do not end with a poly-A tail but a stem-loop. May participate in circularizing those mRNAs specifically enhancing their translation (256 aa)
ZC3H14zinc finger CCCH-type containing 14 (736 aa)
POLDIP3polymerase (DNA-directed), delta interacting protein 3 (421 aa)
XPO5exportin 5 (1204 aa)
MCM3APminichromosome maintenance complex component 3 associated protein; May be involved in the nuclear localization pathway of MCM3 (1980 aa)
NXF1nuclear RNA export factor 1; Involved in the nuclear export of mRNA species bearing retroviral constitutive transport elements (CTE) and in the export of mRNA from the nucleus to the cytoplasm. The NXF1-NXT1 heterodimer is involved in the export of HSP70 mRNA in conjunction with ALYREF/THOC4 and THOC5 (619 aa)
XPO6exportin 6; Mediates the nuclear export of actin and profilin-actin complexes in somatic cells (1125 aa)
DDX19ADEAD (Asp-Glu-Ala-Asp) box polypeptide 19A; ATP-dependent RNA helicase involved in mRNA export from the nucleus. Rather than unwinding RNA duplexes, DDX19 functions as a remodeler of ribonucleoprotein particles, whereby proteins bound to nuclear mRNA are dissociated and replaced by cytoplasmic mRNA binding proteins (By similarity) (478 aa)
DRAP1DR1-associated protein 1 (negative cofactor 2 alpha); The association of the DR1/DRAP1 heterodimer with TBP results in a functional repression of both activated and basal transcription of class II genes. This interaction precludes the formation of a transcription-competent complex by inhibiting the association of TFIIA and/or TFIIB with TBP. Can bind to DNA on its own (205 aa)
GLE1GLE1 RNA export mediator homolog (yeast); Required for the export of mRNAs containing poly(A) tails from the nucleus into the cytoplasm. May be involved in the terminal step of the mRNA transport through the nuclear pore complex (NPC) (698 aa)
PABPC1poly(A) binding protein, cytoplasmic 1; Binds the poly(A) tail of mRNA. May be involved in cytoplasmic regulatory processes of mRNA metabolism such as pre- mRNA splicing. Its function in translational initiation regulation can either be enhanced by PAIP1 or repressed by PAIP2. Can probably bind to cytoplasmic RNA sequences other than poly(A) in vivo. Involved in translationally coupled mRNA turnover. Implicated with other RNA-binding proteins in the cytoplasmic deadenylation/translational and decay interplay of the FOS mRNA mediated by the major coding-region determinant of instability [...] (636 aa)
RPTNrepetin; Involved in the cornified cell envelope formation. Multifunctional epidermal matrix protein. Reversibly binds calcium (784 aa)
NXF2nuclear RNA export factor 2 (626 aa)
UBCubiquitin C (685 aa)
SPTBN1spectrin, beta, non-erythrocytic 1; Fodrin, which seems to be involved in secretion, interacts with calmodulin in a calcium-dependent manner and is thus candidate for the calcium-dependent movement of the cytoskeleton at the membrane (2364 aa)
TPRtranslocated promoter region, nuclear basket protein; Component of the nuclear pore complex (NPC), a complex required for the trafficking across the nuclear envelope. Functions as a scaffolding element in the nuclear phase of the NPC essential for normal nucleocytoplasmic transport of proteins and mRNAs, plays a role in the establishment of nuclear-peripheral chromatin compartmentalization in interphase, and in the mitotic spindle checkpoint signaling during mitosis. Involved in the quality control and retention of unspliced mRNAs in the nucleus; in association with NUP153, regulates t [...] (2363 aa)
FUBP1far upstream element (FUSE) binding protein 1; Regulates MYC expression by binding to a single-stranded far-upstream element (FUSE) upstream of the MYC promoter. May act both as activator and repressor of transcription (644 aa)
SPTAN1spectrin, alpha, non-erythrocytic 1 (2477 aa)
NXF2Bnuclear RNA export factor 2B; Involved in the export of mRNA from the nucleus to the cytoplasm (626 aa)
PABPC1L2Bpoly(A) binding protein, cytoplasmic 1-like 2B (200 aa)
NXF3nuclear RNA export factor 3; May function as a tissue-specific nuclear mRNA export factor (531 aa)
SAC3D1SAC3 domain containing 1; Involved in centrosome duplication and mitotic progression (By similarity) (358 aa)
XPO1exportin 1 (CRM1 homolog, yeast); Mediates the nuclear export of cellular proteins (cargos) bearing a leucine-rich nuclear export signal (NES) and of RNAs. In the nucleus, in association with RANBP3, binds cooperatively to the NES on its target protein and to the GTPase RAN in its active GTP-bound form (Ran-GTP). Docking of this complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) c [...] (1071 aa)
ALYREFAly/REF export factor; Component of the THO subcomplex of the TREX complex. The TREX complex specifically associates with spliced mRNA and not with unspliced pre-mRNA. It is recruited to spliced mRNAs by a transcription-independent mechanism. Binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5’ end of the mRNA where it functions in mRNA export. The recruitment occurs via an interaction between ALYREF/THOC4 and the cap-binding protein NCBP1. DDX39B functions as a bridge between ALYREF/THOC4 and the THO [...] (264 aa)
NXF5nuclear RNA export factor 5 (365 aa)
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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