node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ANTXR1 | ANTXR2 | ENSP00000301945 | ENSP00000306185 | anthrax toxin receptor 1; Plays a role in cell attachment and migration. Interacts with extracellular matrix proteins and with the actin cytoskeleton. Mediates adhesion of cells to type 1 collagen and gelatin, reorganization of the actin cytoskeleton and promotes cell spreading. Plays a role in the angiogenic response of cultured umbilical vein endothelial cells | anthrax toxin receptor 2; Necessary for cellular interactions with laminin and the extracellular matrix | 0.903 |
ANTXR1 | LRP6 | ENSP00000301945 | ENSP00000261349 | anthrax toxin receptor 1; Plays a role in cell attachment and migration. Interacts with extracellular matrix proteins and with the actin cytoskeleton. Mediates adhesion of cells to type 1 collagen and gelatin, reorganization of the actin cytoskeleton and promotes cell spreading. Plays a role in the angiogenic response of cultured umbilical vein endothelial cells | low density lipoprotein receptor-related protein 6; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor- ligand complexes into ribosome-sized signalsomes. Cell-surface coreceptor of Wnt/beta-catenin signaling, which plays a pivotal role in bone formation. The Wnt-induced Fzd/LRP6 coreceptor complex recruits DVL1 polymers to the plasma membrane which, in turn, recruits the AXIN1/GSK3B-complex to the cell surface promoting the formation of signalsomes and inhibiting AXIN1/GSK3- mediated phosphorylation and destruction o [...] | 0.766 |
ANTXR2 | ANTXR1 | ENSP00000306185 | ENSP00000301945 | anthrax toxin receptor 2; Necessary for cellular interactions with laminin and the extracellular matrix | anthrax toxin receptor 1; Plays a role in cell attachment and migration. Interacts with extracellular matrix proteins and with the actin cytoskeleton. Mediates adhesion of cells to type 1 collagen and gelatin, reorganization of the actin cytoskeleton and promotes cell spreading. Plays a role in the angiogenic response of cultured umbilical vein endothelial cells | 0.903 |
ANTXR2 | COL4A2 | ENSP00000306185 | ENSP00000353654 | anthrax toxin receptor 2; Necessary for cellular interactions with laminin and the extracellular matrix | collagen, type IV, alpha 2; Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a ’chicken-wire’ meshwork together with laminins, proteoglycans and entactin/nidogen | 0.569 |
ANTXR2 | COL4A3 | ENSP00000306185 | ENSP00000379823 | anthrax toxin receptor 2; Necessary for cellular interactions with laminin and the extracellular matrix | collagen, type IV, alpha 3 (Goodpasture antigen) | 0.567 |
ANTXR2 | COL4A4 | ENSP00000306185 | ENSP00000379866 | anthrax toxin receptor 2; Necessary for cellular interactions with laminin and the extracellular matrix | collagen, type IV, alpha 4; Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a ’chicken-wire’ meshwork together with laminins, proteoglycans and entactin/nidogen | 0.567 |
ANTXR2 | COL4A5 | ENSP00000306185 | ENSP00000331902 | anthrax toxin receptor 2; Necessary for cellular interactions with laminin and the extracellular matrix | collagen, type IV, alpha 5; Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a ’chicken-wire’ meshwork together with laminins, proteoglycans and entactin/nidogen | 0.567 |
ANTXR2 | LAMB1 | ENSP00000306185 | ENSP00000222399 | anthrax toxin receptor 2; Necessary for cellular interactions with laminin and the extracellular matrix | laminin, beta 1; Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components | 0.567 |
ANTXR2 | LAMC1 | ENSP00000306185 | ENSP00000258341 | anthrax toxin receptor 2; Necessary for cellular interactions with laminin and the extracellular matrix | laminin, gamma 1 (formerly LAMB2); Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components | 0.567 |
ANTXR2 | LRP6 | ENSP00000306185 | ENSP00000261349 | anthrax toxin receptor 2; Necessary for cellular interactions with laminin and the extracellular matrix | low density lipoprotein receptor-related protein 6; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor- ligand complexes into ribosome-sized signalsomes. Cell-surface coreceptor of Wnt/beta-catenin signaling, which plays a pivotal role in bone formation. The Wnt-induced Fzd/LRP6 coreceptor complex recruits DVL1 polymers to the plasma membrane which, in turn, recruits the AXIN1/GSK3B-complex to the cell surface promoting the formation of signalsomes and inhibiting AXIN1/GSK3- mediated phosphorylation and destruction o [...] | 0.717 |
COL4A2 | ANTXR2 | ENSP00000353654 | ENSP00000306185 | collagen, type IV, alpha 2; Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a ’chicken-wire’ meshwork together with laminins, proteoglycans and entactin/nidogen | anthrax toxin receptor 2; Necessary for cellular interactions with laminin and the extracellular matrix | 0.569 |
COL4A2 | COL4A3 | ENSP00000353654 | ENSP00000379823 | collagen, type IV, alpha 2; Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a ’chicken-wire’ meshwork together with laminins, proteoglycans and entactin/nidogen | collagen, type IV, alpha 3 (Goodpasture antigen) | 0.919 |
COL4A2 | COL4A4 | ENSP00000353654 | ENSP00000379866 | collagen, type IV, alpha 2; Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a ’chicken-wire’ meshwork together with laminins, proteoglycans and entactin/nidogen | collagen, type IV, alpha 4; Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a ’chicken-wire’ meshwork together with laminins, proteoglycans and entactin/nidogen | 0.923 |
COL4A2 | COL4A5 | ENSP00000353654 | ENSP00000331902 | collagen, type IV, alpha 2; Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a ’chicken-wire’ meshwork together with laminins, proteoglycans and entactin/nidogen | collagen, type IV, alpha 5; Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a ’chicken-wire’ meshwork together with laminins, proteoglycans and entactin/nidogen | 0.977 |
COL4A2 | LAMB1 | ENSP00000353654 | ENSP00000222399 | collagen, type IV, alpha 2; Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a ’chicken-wire’ meshwork together with laminins, proteoglycans and entactin/nidogen | laminin, beta 1; Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components | 0.493 |
COL4A2 | LAMC1 | ENSP00000353654 | ENSP00000258341 | collagen, type IV, alpha 2; Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a ’chicken-wire’ meshwork together with laminins, proteoglycans and entactin/nidogen | laminin, gamma 1 (formerly LAMB2); Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components | 0.428 |
COL4A3 | ANTXR2 | ENSP00000379823 | ENSP00000306185 | collagen, type IV, alpha 3 (Goodpasture antigen) | anthrax toxin receptor 2; Necessary for cellular interactions with laminin and the extracellular matrix | 0.567 |
COL4A3 | COL4A2 | ENSP00000379823 | ENSP00000353654 | collagen, type IV, alpha 3 (Goodpasture antigen) | collagen, type IV, alpha 2; Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a ’chicken-wire’ meshwork together with laminins, proteoglycans and entactin/nidogen | 0.919 |
COL4A3 | COL4A4 | ENSP00000379823 | ENSP00000379866 | collagen, type IV, alpha 3 (Goodpasture antigen) | collagen, type IV, alpha 4; Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a ’chicken-wire’ meshwork together with laminins, proteoglycans and entactin/nidogen | 0.929 |
COL4A3 | COL4A5 | ENSP00000379823 | ENSP00000331902 | collagen, type IV, alpha 3 (Goodpasture antigen) | collagen, type IV, alpha 5; Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a ’chicken-wire’ meshwork together with laminins, proteoglycans and entactin/nidogen | 0.935 |