Export your current network:
... as a bitmap image:
file format is 'PNG': portable network graphic
... as a high-resolution bitmap:
same PNG format, but resolution at 400 dpi
... as a vector graphic:
SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc
... as simple tabular text output:
TSV: tab separated values - can be opened in Excel
... as an XML summary:
structured XML interaction data, according to the 'PSI-MI' data standard
... network coordinates:
a flat-file format describing the coordinates and colors of nodes in the network
... protein sequences:
MFA: multi-fasta format - containing the aminoacid sequences in the network
... protein annotations:
a tab-delimited file describing the names, domains and annotated functions of the network proteins
Browse interactions in tabular form:
| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| CDC42BPB | KRT78 | ENSP00000355237 | ENSP00000306261 | CDC42 binding protein kinase beta (DMPK-like); Serine/threonine-protein kinase which is an important downstream effector of CDC42 and plays a role in the regulation of cytoskeleton reorganization and cell migration. Regulates actin cytoskeletal reorganization via phosphorylation of PPP1R12C and MYL9/MLC2. In concert with MYO18A and LURAP1, is involved in modulating lamellar actomyosin retrograde flow that is crucial to cell protrusion and migration. Phosphorylates PPP1R12A | keratin 78 | 0.504 |
| CDC42BPB | UBC | ENSP00000355237 | ENSP00000344818 | CDC42 binding protein kinase beta (DMPK-like); Serine/threonine-protein kinase which is an important downstream effector of CDC42 and plays a role in the regulation of cytoskeleton reorganization and cell migration. Regulates actin cytoskeletal reorganization via phosphorylation of PPP1R12C and MYL9/MLC2. In concert with MYO18A and LURAP1, is involved in modulating lamellar actomyosin retrograde flow that is crucial to cell protrusion and migration. Phosphorylates PPP1R12A | ubiquitin C | 0.751 |
| CRK | UBC | ENSP00000300574 | ENSP00000344818 | v-crk sarcoma virus CT10 oncogene homolog (avian); The Crk-I and Crk-II forms differ in their biological activities. Crk-II has less transforming activity than Crk-I. Crk- II mediates attachment-induced MAPK8 activation, membrane ruffling and cell motility in a Rac-dependent manner. Involved in phagocytosis of apoptotic cells and cell motility via its interaction with DOCK1 and DOCK4. May regulate the EFNA5-EPHA3 signaling | ubiquitin C | 0.513 |
| IQCB1 | UBC | ENSP00000311505 | ENSP00000344818 | IQ motif containing B1; Involved in ciliogenesis (By similarity) | ubiquitin C | 0.671 |
| KRT78 | CDC42BPB | ENSP00000306261 | ENSP00000355237 | keratin 78 | CDC42 binding protein kinase beta (DMPK-like); Serine/threonine-protein kinase which is an important downstream effector of CDC42 and plays a role in the regulation of cytoskeleton reorganization and cell migration. Regulates actin cytoskeletal reorganization via phosphorylation of PPP1R12C and MYL9/MLC2. In concert with MYO18A and LURAP1, is involved in modulating lamellar actomyosin retrograde flow that is crucial to cell protrusion and migration. Phosphorylates PPP1R12A | 0.504 |
| KRT78 | UBC | ENSP00000306261 | ENSP00000344818 | keratin 78 | ubiquitin C | 0.741 |
| PPP2R2B | UBC | ENSP00000336591 | ENSP00000344818 | protein phosphatase 2, regulatory subunit B, beta | ubiquitin C | 0.686 |
| SIRT2 | UBC | ENSP00000249396 | ENSP00000344818 | sirtuin 2; NAD-dependent protein deacetylase, which deacetylates internal lysines on histone and non-histone proteins. Deacetylates ’Lys-40’ of alpha-tubulin. Involved in the control of mitotic exit in the cell cycle, probably via its role in the regulation of cytoskeleton. Deacetylates PCK1, opposing proteasomal degradation. Deacetylates ’Lys-310’ of RELA | ubiquitin C | 0.844 |
| UBC | CDC42BPB | ENSP00000344818 | ENSP00000355237 | ubiquitin C | CDC42 binding protein kinase beta (DMPK-like); Serine/threonine-protein kinase which is an important downstream effector of CDC42 and plays a role in the regulation of cytoskeleton reorganization and cell migration. Regulates actin cytoskeletal reorganization via phosphorylation of PPP1R12C and MYL9/MLC2. In concert with MYO18A and LURAP1, is involved in modulating lamellar actomyosin retrograde flow that is crucial to cell protrusion and migration. Phosphorylates PPP1R12A | 0.751 |
| UBC | CRK | ENSP00000344818 | ENSP00000300574 | ubiquitin C | v-crk sarcoma virus CT10 oncogene homolog (avian); The Crk-I and Crk-II forms differ in their biological activities. Crk-II has less transforming activity than Crk-I. Crk- II mediates attachment-induced MAPK8 activation, membrane ruffling and cell motility in a Rac-dependent manner. Involved in phagocytosis of apoptotic cells and cell motility via its interaction with DOCK1 and DOCK4. May regulate the EFNA5-EPHA3 signaling | 0.513 |
| UBC | IQCB1 | ENSP00000344818 | ENSP00000311505 | ubiquitin C | IQ motif containing B1; Involved in ciliogenesis (By similarity) | 0.671 |
| UBC | KRT78 | ENSP00000344818 | ENSP00000306261 | ubiquitin C | keratin 78 | 0.741 |
| UBC | PPP2R2B | ENSP00000344818 | ENSP00000336591 | ubiquitin C | protein phosphatase 2, regulatory subunit B, beta | 0.686 |
| UBC | SIRT2 | ENSP00000344818 | ENSP00000249396 | ubiquitin C | sirtuin 2; NAD-dependent protein deacetylase, which deacetylates internal lysines on histone and non-histone proteins. Deacetylates ’Lys-40’ of alpha-tubulin. Involved in the control of mitotic exit in the cell cycle, probably via its role in the regulation of cytoskeleton. Deacetylates PCK1, opposing proteasomal degradation. Deacetylates ’Lys-310’ of RELA | 0.844 |
| UBC | UCHL5 | ENSP00000344818 | ENSP00000356425 | ubiquitin C | ubiquitin carboxyl-terminal hydrolase L5; Protease that specifically cleaves ’Lys-48’-linked polyubiquitin chains. Deubiquitinating enzyme associated with the 19S regulatory subunit of the 26S proteasome. Putative regulatory component of the INO80 complex; however is inactive in the INO80 complex and is activated by a transient interaction of the INO80 complex with the proteasome via ADRM1 | 0.999 |
| UCHL5 | UBC | ENSP00000356425 | ENSP00000344818 | ubiquitin carboxyl-terminal hydrolase L5; Protease that specifically cleaves ’Lys-48’-linked polyubiquitin chains. Deubiquitinating enzyme associated with the 19S regulatory subunit of the 26S proteasome. Putative regulatory component of the INO80 complex; however is inactive in the INO80 complex and is activated by a transient interaction of the INO80 complex with the proteasome via ADRM1 | ubiquitin C | 0.999 |
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