node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
A4GALT | B3GNT5 | ENSP00000249005 | ENSP00000316173 | alpha 1,4-galactosyltransferase; Necessary for the biosynthesis of the Pk antigen of blood histogroup P. Catalyzes the transfer of galactose to lactosylceramide and galactosylceramide. Necessary for the synthesis of the receptor for bacterial verotoxins | UDP-GlcNAc-betaGal beta-1,3-N-acetylglucosaminyltransferase 5; Beta-1,3-N-acetylglucosaminyltransferase that plays a key role in the synthesis of lacto- or neolacto-series carbohydrate chains on glycolipids, notably by participating in biosynthesis of HNK-1 and Lewis X carbohydrate structures. Has strong activity toward lactosylceramide (LacCer) and neolactotetraosylceramide (nLc(4)Cer; paragloboside), resulting in the synthesis of Lc(3)Cer and neolactopentaosylceramide (nLc(5)Cer), respectively. Probably plays a central role in regulating neolacto-series glycolipid synthesis during em [...] | 0.436 |
A4GALT | B4GALT6 | ENSP00000249005 | ENSP00000306459 | alpha 1,4-galactosyltransferase; Necessary for the biosynthesis of the Pk antigen of blood histogroup P. Catalyzes the transfer of galactose to lactosylceramide and galactosylceramide. Necessary for the synthesis of the receptor for bacterial verotoxins | UDP-Gal-betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 6; Required for the biosynthesis of glycosphingolipids | 0.866 |
A4GALT | GLB1 | ENSP00000249005 | ENSP00000306920 | alpha 1,4-galactosyltransferase; Necessary for the biosynthesis of the Pk antigen of blood histogroup P. Catalyzes the transfer of galactose to lactosylceramide and galactosylceramide. Necessary for the synthesis of the receptor for bacterial verotoxins | galactosidase, beta 1; Cleaves beta-linked terminal galactosyl residues from gangliosides, glycoproteins, and glycosaminoglycans | 0.800 |
A4GALT | UGCG | ENSP00000249005 | ENSP00000363397 | alpha 1,4-galactosyltransferase; Necessary for the biosynthesis of the Pk antigen of blood histogroup P. Catalyzes the transfer of galactose to lactosylceramide and galactosylceramide. Necessary for the synthesis of the receptor for bacterial verotoxins | UDP-glucose ceramide glucosyltransferase; Catalyzes the first glycosylation step in glycosphingolipid biosynthesis, the transfer of glucose to ceramide. May also serve as a "flippase" | 0.503 |
B3GNT5 | A4GALT | ENSP00000316173 | ENSP00000249005 | UDP-GlcNAc-betaGal beta-1,3-N-acetylglucosaminyltransferase 5; Beta-1,3-N-acetylglucosaminyltransferase that plays a key role in the synthesis of lacto- or neolacto-series carbohydrate chains on glycolipids, notably by participating in biosynthesis of HNK-1 and Lewis X carbohydrate structures. Has strong activity toward lactosylceramide (LacCer) and neolactotetraosylceramide (nLc(4)Cer; paragloboside), resulting in the synthesis of Lc(3)Cer and neolactopentaosylceramide (nLc(5)Cer), respectively. Probably plays a central role in regulating neolacto-series glycolipid synthesis during em [...] | alpha 1,4-galactosyltransferase; Necessary for the biosynthesis of the Pk antigen of blood histogroup P. Catalyzes the transfer of galactose to lactosylceramide and galactosylceramide. Necessary for the synthesis of the receptor for bacterial verotoxins | 0.436 |
B3GNT5 | B4GALT6 | ENSP00000316173 | ENSP00000306459 | UDP-GlcNAc-betaGal beta-1,3-N-acetylglucosaminyltransferase 5; Beta-1,3-N-acetylglucosaminyltransferase that plays a key role in the synthesis of lacto- or neolacto-series carbohydrate chains on glycolipids, notably by participating in biosynthesis of HNK-1 and Lewis X carbohydrate structures. Has strong activity toward lactosylceramide (LacCer) and neolactotetraosylceramide (nLc(4)Cer; paragloboside), resulting in the synthesis of Lc(3)Cer and neolactopentaosylceramide (nLc(5)Cer), respectively. Probably plays a central role in regulating neolacto-series glycolipid synthesis during em [...] | UDP-Gal-betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 6; Required for the biosynthesis of glycosphingolipids | 0.865 |
B3GNT5 | GLB1 | ENSP00000316173 | ENSP00000306920 | UDP-GlcNAc-betaGal beta-1,3-N-acetylglucosaminyltransferase 5; Beta-1,3-N-acetylglucosaminyltransferase that plays a key role in the synthesis of lacto- or neolacto-series carbohydrate chains on glycolipids, notably by participating in biosynthesis of HNK-1 and Lewis X carbohydrate structures. Has strong activity toward lactosylceramide (LacCer) and neolactotetraosylceramide (nLc(4)Cer; paragloboside), resulting in the synthesis of Lc(3)Cer and neolactopentaosylceramide (nLc(5)Cer), respectively. Probably plays a central role in regulating neolacto-series glycolipid synthesis during em [...] | galactosidase, beta 1; Cleaves beta-linked terminal galactosyl residues from gangliosides, glycoproteins, and glycosaminoglycans | 0.800 |
B4GALNT1 | B4GALT6 | ENSP00000341562 | ENSP00000306459 | beta-1,4-N-acetyl-galactosaminyl transferase 1; Involved in the biosynthesis of gangliosides GM2, GD2 and GA2 | UDP-Gal-betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 6; Required for the biosynthesis of glycosphingolipids | 0.852 |
B4GALNT1 | GLB1 | ENSP00000341562 | ENSP00000306920 | beta-1,4-N-acetyl-galactosaminyl transferase 1; Involved in the biosynthesis of gangliosides GM2, GD2 and GA2 | galactosidase, beta 1; Cleaves beta-linked terminal galactosyl residues from gangliosides, glycoproteins, and glycosaminoglycans | 0.903 |
B4GALNT1 | ST3GAL5 | ENSP00000341562 | ENSP00000366549 | beta-1,4-N-acetyl-galactosaminyl transferase 1; Involved in the biosynthesis of gangliosides GM2, GD2 and GA2 | ST3 beta-galactoside alpha-2,3-sialyltransferase 5; Catalyzes the formation of ganglioside GM3 (alpha-N- acetylneuraminyl-2,3-beta-D-galactosyl-1, 4-beta-D- glucosylceramide) | 0.959 |
B4GALT6 | A4GALT | ENSP00000306459 | ENSP00000249005 | UDP-Gal-betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 6; Required for the biosynthesis of glycosphingolipids | alpha 1,4-galactosyltransferase; Necessary for the biosynthesis of the Pk antigen of blood histogroup P. Catalyzes the transfer of galactose to lactosylceramide and galactosylceramide. Necessary for the synthesis of the receptor for bacterial verotoxins | 0.866 |
B4GALT6 | B3GNT5 | ENSP00000306459 | ENSP00000316173 | UDP-Gal-betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 6; Required for the biosynthesis of glycosphingolipids | UDP-GlcNAc-betaGal beta-1,3-N-acetylglucosaminyltransferase 5; Beta-1,3-N-acetylglucosaminyltransferase that plays a key role in the synthesis of lacto- or neolacto-series carbohydrate chains on glycolipids, notably by participating in biosynthesis of HNK-1 and Lewis X carbohydrate structures. Has strong activity toward lactosylceramide (LacCer) and neolactotetraosylceramide (nLc(4)Cer; paragloboside), resulting in the synthesis of Lc(3)Cer and neolactopentaosylceramide (nLc(5)Cer), respectively. Probably plays a central role in regulating neolacto-series glycolipid synthesis during em [...] | 0.865 |
B4GALT6 | B4GALNT1 | ENSP00000306459 | ENSP00000341562 | UDP-Gal-betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 6; Required for the biosynthesis of glycosphingolipids | beta-1,4-N-acetyl-galactosaminyl transferase 1; Involved in the biosynthesis of gangliosides GM2, GD2 and GA2 | 0.852 |
B4GALT6 | GBA2 | ENSP00000306459 | ENSP00000367343 | UDP-Gal-betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 6; Required for the biosynthesis of glycosphingolipids | glucosidase, beta (bile acid) 2; Non-lysosomal glucosylceramidase that catalyzes the conversion of glucosylceramide (GlcCer) to free glucose and ceramide. Involved in sphingomyelin generation and prevention of glycolipid accumulation. May also catalyze the hydrolysis of bile acid 3-O-glucosides, however, the relevance of such activity is unclear in vivo | 0.900 |
B4GALT6 | GLB1 | ENSP00000306459 | ENSP00000306920 | UDP-Gal-betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 6; Required for the biosynthesis of glycosphingolipids | galactosidase, beta 1; Cleaves beta-linked terminal galactosyl residues from gangliosides, glycoproteins, and glycosaminoglycans | 0.806 |
B4GALT6 | ST3GAL5 | ENSP00000306459 | ENSP00000366549 | UDP-Gal-betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 6; Required for the biosynthesis of glycosphingolipids | ST3 beta-galactoside alpha-2,3-sialyltransferase 5; Catalyzes the formation of ganglioside GM3 (alpha-N- acetylneuraminyl-2,3-beta-D-galactosyl-1, 4-beta-D- glucosylceramide) | 0.837 |
B4GALT6 | UGCG | ENSP00000306459 | ENSP00000363397 | UDP-Gal-betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 6; Required for the biosynthesis of glycosphingolipids | UDP-glucose ceramide glucosyltransferase; Catalyzes the first glycosylation step in glycosphingolipid biosynthesis, the transfer of glucose to ceramide. May also serve as a "flippase" | 0.929 |
GBA2 | B4GALT6 | ENSP00000367343 | ENSP00000306459 | glucosidase, beta (bile acid) 2; Non-lysosomal glucosylceramidase that catalyzes the conversion of glucosylceramide (GlcCer) to free glucose and ceramide. Involved in sphingomyelin generation and prevention of glycolipid accumulation. May also catalyze the hydrolysis of bile acid 3-O-glucosides, however, the relevance of such activity is unclear in vivo | UDP-Gal-betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 6; Required for the biosynthesis of glycosphingolipids | 0.900 |
GBA2 | GLB1 | ENSP00000367343 | ENSP00000306920 | glucosidase, beta (bile acid) 2; Non-lysosomal glucosylceramidase that catalyzes the conversion of glucosylceramide (GlcCer) to free glucose and ceramide. Involved in sphingomyelin generation and prevention of glycolipid accumulation. May also catalyze the hydrolysis of bile acid 3-O-glucosides, however, the relevance of such activity is unclear in vivo | galactosidase, beta 1; Cleaves beta-linked terminal galactosyl residues from gangliosides, glycoproteins, and glycosaminoglycans | 0.908 |
GBA2 | UGCG | ENSP00000367343 | ENSP00000363397 | glucosidase, beta (bile acid) 2; Non-lysosomal glucosylceramidase that catalyzes the conversion of glucosylceramide (GlcCer) to free glucose and ceramide. Involved in sphingomyelin generation and prevention of glycolipid accumulation. May also catalyze the hydrolysis of bile acid 3-O-glucosides, however, the relevance of such activity is unclear in vivo | UDP-glucose ceramide glucosyltransferase; Catalyzes the first glycosylation step in glycosphingolipid biosynthesis, the transfer of glucose to ceramide. May also serve as a "flippase" | 0.903 |