node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CENPA | SHCBP1 | ENSP00000336868 | ENSP00000306473 | centromere protein A; Histone H3-like variant which exclusively replaces conventional H3 in the nucleosome core of centromeric chromatin at the inner plate of the kinetochore. Required for recruitment and assembly of kinetochore proteins, mitotic progression and chromosome segregation. May serve as an epigenetic mark that propagates centromere identity through replication and cell division. The CENPA-H4 heterotetramer can bind DNA by itself (in vitro) | SHC SH2-domain binding protein 1; May play a role in signaling pathways governing cellular proliferation, cell growth and differentiation. May be a component of a novel signaling pathway downstream of Shc. Acts as a positive regulator of FGF signaling in neural progenitor cells (By similarity) | 0.549 |
SH3KBP1 | UBC | ENSP00000380921 | ENSP00000344818 | SH3-domain kinase binding protein 1; Adapter protein involved in regulating diverse signal transduction pathways. Involved in the regulation of endocytosis and lysosomal degradation of ligand-induced receptor tyrosine kinases, including EGFR and MET/hepatocyte growth factor receptor, through a association with CBL and endophilins. The association with CBL, and thus the receptor internalization, may inhibited by an interaction with PDCD6IP and/or SPRY2. Involved in regulation of ligand-dependent endocytosis of the IgE receptor. Attenuates phosphatidylinositol 3-kinase activity by intera [...] | ubiquitin C | 0.999 |
SHC1 | SHCBP1 | ENSP00000401303 | ENSP00000306473 | SHC (Src homology 2 domain containing) transforming protein 1 | SHC SH2-domain binding protein 1; May play a role in signaling pathways governing cellular proliferation, cell growth and differentiation. May be a component of a novel signaling pathway downstream of Shc. Acts as a positive regulator of FGF signaling in neural progenitor cells (By similarity) | 0.886 |
SHC1 | UBC | ENSP00000401303 | ENSP00000344818 | SHC (Src homology 2 domain containing) transforming protein 1 | ubiquitin C | 0.850 |
SHCBP1 | CENPA | ENSP00000306473 | ENSP00000336868 | SHC SH2-domain binding protein 1; May play a role in signaling pathways governing cellular proliferation, cell growth and differentiation. May be a component of a novel signaling pathway downstream of Shc. Acts as a positive regulator of FGF signaling in neural progenitor cells (By similarity) | centromere protein A; Histone H3-like variant which exclusively replaces conventional H3 in the nucleosome core of centromeric chromatin at the inner plate of the kinetochore. Required for recruitment and assembly of kinetochore proteins, mitotic progression and chromosome segregation. May serve as an epigenetic mark that propagates centromere identity through replication and cell division. The CENPA-H4 heterotetramer can bind DNA by itself (in vitro) | 0.549 |
SHCBP1 | SHC1 | ENSP00000306473 | ENSP00000401303 | SHC SH2-domain binding protein 1; May play a role in signaling pathways governing cellular proliferation, cell growth and differentiation. May be a component of a novel signaling pathway downstream of Shc. Acts as a positive regulator of FGF signaling in neural progenitor cells (By similarity) | SHC (Src homology 2 domain containing) transforming protein 1 | 0.886 |
SHCBP1 | SRSF11 | ENSP00000306473 | ENSP00000359988 | SHC SH2-domain binding protein 1; May play a role in signaling pathways governing cellular proliferation, cell growth and differentiation. May be a component of a novel signaling pathway downstream of Shc. Acts as a positive regulator of FGF signaling in neural progenitor cells (By similarity) | serine/arginine-rich splicing factor 11; May function in pre-mRNA splicing | 0.644 |
SHCBP1 | UBC | ENSP00000306473 | ENSP00000344818 | SHC SH2-domain binding protein 1; May play a role in signaling pathways governing cellular proliferation, cell growth and differentiation. May be a component of a novel signaling pathway downstream of Shc. Acts as a positive regulator of FGF signaling in neural progenitor cells (By similarity) | ubiquitin C | 0.849 |
SHCBP1 | USP49 | ENSP00000306473 | ENSP00000297229 | SHC SH2-domain binding protein 1; May play a role in signaling pathways governing cellular proliferation, cell growth and differentiation. May be a component of a novel signaling pathway downstream of Shc. Acts as a positive regulator of FGF signaling in neural progenitor cells (By similarity) | ubiquitin specific peptidase 49 | 0.740 |
SHCBP1 | ZUFSP | ENSP00000306473 | ENSP00000357565 | SHC SH2-domain binding protein 1; May play a role in signaling pathways governing cellular proliferation, cell growth and differentiation. May be a component of a novel signaling pathway downstream of Shc. Acts as a positive regulator of FGF signaling in neural progenitor cells (By similarity) | zinc finger with UFM1-specific peptidase domain | 0.826 |
SRSF11 | SHCBP1 | ENSP00000359988 | ENSP00000306473 | serine/arginine-rich splicing factor 11; May function in pre-mRNA splicing | SHC SH2-domain binding protein 1; May play a role in signaling pathways governing cellular proliferation, cell growth and differentiation. May be a component of a novel signaling pathway downstream of Shc. Acts as a positive regulator of FGF signaling in neural progenitor cells (By similarity) | 0.644 |
SRSF11 | UBC | ENSP00000359988 | ENSP00000344818 | serine/arginine-rich splicing factor 11; May function in pre-mRNA splicing | ubiquitin C | 0.795 |
UBC | SH3KBP1 | ENSP00000344818 | ENSP00000380921 | ubiquitin C | SH3-domain kinase binding protein 1; Adapter protein involved in regulating diverse signal transduction pathways. Involved in the regulation of endocytosis and lysosomal degradation of ligand-induced receptor tyrosine kinases, including EGFR and MET/hepatocyte growth factor receptor, through a association with CBL and endophilins. The association with CBL, and thus the receptor internalization, may inhibited by an interaction with PDCD6IP and/or SPRY2. Involved in regulation of ligand-dependent endocytosis of the IgE receptor. Attenuates phosphatidylinositol 3-kinase activity by intera [...] | 0.999 |
UBC | SHC1 | ENSP00000344818 | ENSP00000401303 | ubiquitin C | SHC (Src homology 2 domain containing) transforming protein 1 | 0.850 |
UBC | SHCBP1 | ENSP00000344818 | ENSP00000306473 | ubiquitin C | SHC SH2-domain binding protein 1; May play a role in signaling pathways governing cellular proliferation, cell growth and differentiation. May be a component of a novel signaling pathway downstream of Shc. Acts as a positive regulator of FGF signaling in neural progenitor cells (By similarity) | 0.849 |
UBC | SRSF11 | ENSP00000344818 | ENSP00000359988 | ubiquitin C | serine/arginine-rich splicing factor 11; May function in pre-mRNA splicing | 0.795 |
UBC | YWHAG | ENSP00000344818 | ENSP00000306330 | ubiquitin C | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide; Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner | 0.994 |
UBC | ZUFSP | ENSP00000344818 | ENSP00000357565 | ubiquitin C | zinc finger with UFM1-specific peptidase domain | 0.947 |
USP49 | SHCBP1 | ENSP00000297229 | ENSP00000306473 | ubiquitin specific peptidase 49 | SHC SH2-domain binding protein 1; May play a role in signaling pathways governing cellular proliferation, cell growth and differentiation. May be a component of a novel signaling pathway downstream of Shc. Acts as a positive regulator of FGF signaling in neural progenitor cells (By similarity) | 0.740 |
YWHAG | UBC | ENSP00000306330 | ENSP00000344818 | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide; Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner | ubiquitin C | 0.994 |