node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
AASS | BTD | ENSP00000377040 | ENSP00000306477 | aminoadipate-semialdehyde synthase; Bifunctional enzyme that catalyzes the first two steps in lysine degradation. The N-terminal and the C-terminal contain lysine-ketoglutarate reductase and saccharopine dehydrogenase activity, respectively | biotinidase; Catalytic release of biotin from biocytin, the product of biotin-dependent carboxylases degradation | 0.823 |
AASS | UBC | ENSP00000377040 | ENSP00000344818 | aminoadipate-semialdehyde synthase; Bifunctional enzyme that catalyzes the first two steps in lysine degradation. The N-terminal and the C-terminal contain lysine-ketoglutarate reductase and saccharopine dehydrogenase activity, respectively | ubiquitin C | 0.632 |
AMD1 | UBC | ENSP00000357880 | ENSP00000344818 | adenosylmethionine decarboxylase 1 | ubiquitin C | 0.626 |
BTD | AASS | ENSP00000306477 | ENSP00000377040 | biotinidase; Catalytic release of biotin from biocytin, the product of biotin-dependent carboxylases degradation | aminoadipate-semialdehyde synthase; Bifunctional enzyme that catalyzes the first two steps in lysine degradation. The N-terminal and the C-terminal contain lysine-ketoglutarate reductase and saccharopine dehydrogenase activity, respectively | 0.823 |
BTD | HLCS | ENSP00000306477 | ENSP00000338387 | biotinidase; Catalytic release of biotin from biocytin, the product of biotin-dependent carboxylases degradation | holocarboxylase synthetase (biotin-(proprionyl-CoA-carboxylase (ATP-hydrolysing)) ligase); Post-translational modification of specific protein by attachment of biotin. Acts on various carboxylases such as acetyl- CoA-carboxylase, pyruvate carboxylase, propionyl CoA carboxylase, and 3-methylcrotonyl CoA carboxylase | 0.987 |
GGT5 | GGT6 | ENSP00000381340 | ENSP00000458307 | gamma-glutamyltransferase 5; Cleaves the gamma-glutamyl peptide bond of glutathione conjugates, but maybe not glutathione itself. Converts leukotriene C4 (LTC4) to leukotriene D4 (LTD4) | gamma-glutamyltransferase 6; Cleaves glutathione conjugates (By similarity) | 0.770 |
GGT6 | GGT5 | ENSP00000458307 | ENSP00000381340 | gamma-glutamyltransferase 6; Cleaves glutathione conjugates (By similarity) | gamma-glutamyltransferase 5; Cleaves the gamma-glutamyl peptide bond of glutathione conjugates, but maybe not glutathione itself. Converts leukotriene C4 (LTC4) to leukotriene D4 (LTD4) | 0.770 |
GGT6 | GGTLC1 | ENSP00000458307 | ENSP00000278765 | gamma-glutamyltransferase 6; Cleaves glutathione conjugates (By similarity) | gamma-glutamyltransferase light chain 1 | 0.760 |
GGT6 | GGTLC2 | ENSP00000458307 | ENSP00000419751 | gamma-glutamyltransferase 6; Cleaves glutathione conjugates (By similarity) | gamma-glutamyltransferase light chain 2 | 0.744 |
GGTLC1 | GGT6 | ENSP00000278765 | ENSP00000458307 | gamma-glutamyltransferase light chain 1 | gamma-glutamyltransferase 6; Cleaves glutathione conjugates (By similarity) | 0.760 |
GGTLC2 | GGT6 | ENSP00000419751 | ENSP00000458307 | gamma-glutamyltransferase light chain 2 | gamma-glutamyltransferase 6; Cleaves glutathione conjugates (By similarity) | 0.744 |
HIBCH | UBC | ENSP00000352706 | ENSP00000344818 | 3-hydroxyisobutyryl-CoA hydrolase; Hydrolyzes 3-hydroxyisobutyryl-CoA (HIBYL-CoA), a saline catabolite. Has high activity toward isobutyryl-CoA. Could be an isobutyryl-CoA dehydrogenase that functions in valine catabolism. Also hydrolyzes 3-hydroxypropanoyl-CoA | ubiquitin C | 0.721 |
HLCS | BTD | ENSP00000338387 | ENSP00000306477 | holocarboxylase synthetase (biotin-(proprionyl-CoA-carboxylase (ATP-hydrolysing)) ligase); Post-translational modification of specific protein by attachment of biotin. Acts on various carboxylases such as acetyl- CoA-carboxylase, pyruvate carboxylase, propionyl CoA carboxylase, and 3-methylcrotonyl CoA carboxylase | biotinidase; Catalytic release of biotin from biocytin, the product of biotin-dependent carboxylases degradation | 0.987 |
HLCS | UBC | ENSP00000338387 | ENSP00000344818 | holocarboxylase synthetase (biotin-(proprionyl-CoA-carboxylase (ATP-hydrolysing)) ligase); Post-translational modification of specific protein by attachment of biotin. Acts on various carboxylases such as acetyl- CoA-carboxylase, pyruvate carboxylase, propionyl CoA carboxylase, and 3-methylcrotonyl CoA carboxylase | ubiquitin C | 0.560 |
MINPP1 | UBC | ENSP00000361064 | ENSP00000344818 | multiple inositol-polyphosphate phosphatase 1; Acts as a phosphoinositide 5- and phosphoinositide 6- phosphatase and regulates cellular levels of inositol pentakisphosphate (InsP5) and inositol hexakisphosphate (InsP6). Also acts as a 2,3-bisphosphoglycerate 3-phosphatase, by mediating the dephosphorylation of 2,3-bisphosphoglycerate (2,3-BPG) to produce phospho-D-glycerate without formation of 3- phosphoglycerate. May play a role in bone development (endochondral ossification) | ubiquitin C | 0.646 |
PACSIN1 | PACSIN2 | ENSP00000244458 | ENSP00000263246 | protein kinase C and casein kinase substrate in neurons 1; Plays a role in the reorganization of the microtubule cytoskeleton via its interaction with MAPT; this decreases microtubule stability and inhibits MAPT-induced microtubule polymerization. Plays a role in cellular transport processes by recruiting DNM1, DNM2 and DNM3 to membranes. Plays a role in the reorganization of the actin cytoskeleton and in neuron morphogenesis via its interaction with COBL and WASL, and by recruiting COBL to the cell cortex. Plays a role in the regulation of neurite formation, neurite branching and the [...] | protein kinase C and casein kinase substrate in neurons 2; Plays a role in the formation of normal, flask-shaped caveolae at the cell membrane. Recruits DNM2 to caveolae, and thereby plays a role in caveola-mediated endocytosis. Plays a role in intracellular vesicle-mediated transport. Binds to membranes via its F-BAR domain and promotes membrane tubulation. Plays a role in the internalization of cell-surface receptors. Is not required for internalization of EGFR after EGF stimulus, but contributes to the internalization of EGFR in the absence of EGF stimulus | 0.978 |
PACSIN1 | PACSIN3 | ENSP00000244458 | ENSP00000298838 | protein kinase C and casein kinase substrate in neurons 1; Plays a role in the reorganization of the microtubule cytoskeleton via its interaction with MAPT; this decreases microtubule stability and inhibits MAPT-induced microtubule polymerization. Plays a role in cellular transport processes by recruiting DNM1, DNM2 and DNM3 to membranes. Plays a role in the reorganization of the actin cytoskeleton and in neuron morphogenesis via its interaction with COBL and WASL, and by recruiting COBL to the cell cortex. Plays a role in the regulation of neurite formation, neurite branching and the [...] | protein kinase C and casein kinase substrate in neurons 3; May play a role in endocytosis (By similarity) | 0.808 |
PACSIN2 | PACSIN1 | ENSP00000263246 | ENSP00000244458 | protein kinase C and casein kinase substrate in neurons 2; Plays a role in the formation of normal, flask-shaped caveolae at the cell membrane. Recruits DNM2 to caveolae, and thereby plays a role in caveola-mediated endocytosis. Plays a role in intracellular vesicle-mediated transport. Binds to membranes via its F-BAR domain and promotes membrane tubulation. Plays a role in the internalization of cell-surface receptors. Is not required for internalization of EGFR after EGF stimulus, but contributes to the internalization of EGFR in the absence of EGF stimulus | protein kinase C and casein kinase substrate in neurons 1; Plays a role in the reorganization of the microtubule cytoskeleton via its interaction with MAPT; this decreases microtubule stability and inhibits MAPT-induced microtubule polymerization. Plays a role in cellular transport processes by recruiting DNM1, DNM2 and DNM3 to membranes. Plays a role in the reorganization of the actin cytoskeleton and in neuron morphogenesis via its interaction with COBL and WASL, and by recruiting COBL to the cell cortex. Plays a role in the regulation of neurite formation, neurite branching and the [...] | 0.978 |
PACSIN2 | PACSIN3 | ENSP00000263246 | ENSP00000298838 | protein kinase C and casein kinase substrate in neurons 2; Plays a role in the formation of normal, flask-shaped caveolae at the cell membrane. Recruits DNM2 to caveolae, and thereby plays a role in caveola-mediated endocytosis. Plays a role in intracellular vesicle-mediated transport. Binds to membranes via its F-BAR domain and promotes membrane tubulation. Plays a role in the internalization of cell-surface receptors. Is not required for internalization of EGFR after EGF stimulus, but contributes to the internalization of EGFR in the absence of EGF stimulus | protein kinase C and casein kinase substrate in neurons 3; May play a role in endocytosis (By similarity) | 0.585 |
PACSIN2 | UBC | ENSP00000263246 | ENSP00000344818 | protein kinase C and casein kinase substrate in neurons 2; Plays a role in the formation of normal, flask-shaped caveolae at the cell membrane. Recruits DNM2 to caveolae, and thereby plays a role in caveola-mediated endocytosis. Plays a role in intracellular vesicle-mediated transport. Binds to membranes via its F-BAR domain and promotes membrane tubulation. Plays a role in the internalization of cell-surface receptors. Is not required for internalization of EGFR after EGF stimulus, but contributes to the internalization of EGFR in the absence of EGF stimulus | ubiquitin C | 0.620 |