5 items (Homo sapiens) - STRING network view

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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protein of unknown 3D structure

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associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.

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Your Input:
	BCL2L1	BCL2-like 1; Potent inhibitor of cell death. Inhibits activation of caspases (By similarity). Appears to regulate cell death by blocking the voltage-dependent anion channel (VDAC) by binding to it and preventing the release of the caspase activator, CYC1, from the mitochondrial membrane. Also acts as a regulator of G2 checkpoint and progression to cytokinesis during mitosis (233 aa)
	AVEN	apoptosis, caspase activation inhibitor; Protects against apoptosis mediated by Apaf-1 (362 aa)
	BCL2	B-cell CLL/lymphoma 2; Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1) (239 aa)
	UBC	ubiquitin C (685 aa)
	APAF1	apoptotic peptidase activating factor 1 (1248 aa)

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
APAF1	AVEN	ENSP00000448165	ENSP00000306822	apoptotic peptidase activating factor 1	apoptosis, caspase activation inhibitor; Protects against apoptosis mediated by Apaf-1	0.786
APAF1	BCL2	ENSP00000448165	ENSP00000329623	apoptotic peptidase activating factor 1	B-cell CLL/lymphoma 2; Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1)	0.999
APAF1	BCL2L1	ENSP00000448165	ENSP00000302564	apoptotic peptidase activating factor 1	BCL2-like 1; Potent inhibitor of cell death. Inhibits activation of caspases (By similarity). Appears to regulate cell death by blocking the voltage-dependent anion channel (VDAC) by binding to it and preventing the release of the caspase activator, CYC1, from the mitochondrial membrane. Also acts as a regulator of G2 checkpoint and progression to cytokinesis during mitosis	0.999
APAF1	UBC	ENSP00000448165	ENSP00000344818	apoptotic peptidase activating factor 1	ubiquitin C	0.755
AVEN	APAF1	ENSP00000306822	ENSP00000448165	apoptosis, caspase activation inhibitor; Protects against apoptosis mediated by Apaf-1	apoptotic peptidase activating factor 1	0.786
AVEN	BCL2	ENSP00000306822	ENSP00000329623	apoptosis, caspase activation inhibitor; Protects against apoptosis mediated by Apaf-1	B-cell CLL/lymphoma 2; Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1)	0.731
AVEN	BCL2L1	ENSP00000306822	ENSP00000302564	apoptosis, caspase activation inhibitor; Protects against apoptosis mediated by Apaf-1	BCL2-like 1; Potent inhibitor of cell death. Inhibits activation of caspases (By similarity). Appears to regulate cell death by blocking the voltage-dependent anion channel (VDAC) by binding to it and preventing the release of the caspase activator, CYC1, from the mitochondrial membrane. Also acts as a regulator of G2 checkpoint and progression to cytokinesis during mitosis	0.839
AVEN	UBC	ENSP00000306822	ENSP00000344818	apoptosis, caspase activation inhibitor; Protects against apoptosis mediated by Apaf-1	ubiquitin C	0.727
BCL2	APAF1	ENSP00000329623	ENSP00000448165	B-cell CLL/lymphoma 2; Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1)	apoptotic peptidase activating factor 1	0.999
BCL2	AVEN	ENSP00000329623	ENSP00000306822	B-cell CLL/lymphoma 2; Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1)	apoptosis, caspase activation inhibitor; Protects against apoptosis mediated by Apaf-1	0.731
BCL2	BCL2L1	ENSP00000329623	ENSP00000302564	B-cell CLL/lymphoma 2; Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1)	BCL2-like 1; Potent inhibitor of cell death. Inhibits activation of caspases (By similarity). Appears to regulate cell death by blocking the voltage-dependent anion channel (VDAC) by binding to it and preventing the release of the caspase activator, CYC1, from the mitochondrial membrane. Also acts as a regulator of G2 checkpoint and progression to cytokinesis during mitosis	0.996
BCL2	UBC	ENSP00000329623	ENSP00000344818	B-cell CLL/lymphoma 2; Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1)	ubiquitin C	0.933
BCL2L1	APAF1	ENSP00000302564	ENSP00000448165	BCL2-like 1; Potent inhibitor of cell death. Inhibits activation of caspases (By similarity). Appears to regulate cell death by blocking the voltage-dependent anion channel (VDAC) by binding to it and preventing the release of the caspase activator, CYC1, from the mitochondrial membrane. Also acts as a regulator of G2 checkpoint and progression to cytokinesis during mitosis	apoptotic peptidase activating factor 1	0.999
BCL2L1	AVEN	ENSP00000302564	ENSP00000306822	BCL2-like 1; Potent inhibitor of cell death. Inhibits activation of caspases (By similarity). Appears to regulate cell death by blocking the voltage-dependent anion channel (VDAC) by binding to it and preventing the release of the caspase activator, CYC1, from the mitochondrial membrane. Also acts as a regulator of G2 checkpoint and progression to cytokinesis during mitosis	apoptosis, caspase activation inhibitor; Protects against apoptosis mediated by Apaf-1	0.839
BCL2L1	BCL2	ENSP00000302564	ENSP00000329623	BCL2-like 1; Potent inhibitor of cell death. Inhibits activation of caspases (By similarity). Appears to regulate cell death by blocking the voltage-dependent anion channel (VDAC) by binding to it and preventing the release of the caspase activator, CYC1, from the mitochondrial membrane. Also acts as a regulator of G2 checkpoint and progression to cytokinesis during mitosis	B-cell CLL/lymphoma 2; Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1)	0.996
BCL2L1	UBC	ENSP00000302564	ENSP00000344818	BCL2-like 1; Potent inhibitor of cell death. Inhibits activation of caspases (By similarity). Appears to regulate cell death by blocking the voltage-dependent anion channel (VDAC) by binding to it and preventing the release of the caspase activator, CYC1, from the mitochondrial membrane. Also acts as a regulator of G2 checkpoint and progression to cytokinesis during mitosis	ubiquitin C	0.983
UBC	APAF1	ENSP00000344818	ENSP00000448165	ubiquitin C	apoptotic peptidase activating factor 1	0.755
UBC	AVEN	ENSP00000344818	ENSP00000306822	ubiquitin C	apoptosis, caspase activation inhibitor; Protects against apoptosis mediated by Apaf-1	0.727
UBC	BCL2	ENSP00000344818	ENSP00000329623	ubiquitin C	B-cell CLL/lymphoma 2; Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1)	0.933
UBC	BCL2L1	ENSP00000344818	ENSP00000302564	ubiquitin C	BCL2-like 1; Potent inhibitor of cell death. Inhibits activation of caspases (By similarity). Appears to regulate cell death by blocking the voltage-dependent anion channel (VDAC) by binding to it and preventing the release of the caspase activator, CYC1, from the mitochondrial membrane. Also acts as a regulator of G2 checkpoint and progression to cytokinesis during mitosis	0.983

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