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STRINGSTRING
UPRT UPRT PTPN20B PTPN20B PTPN21 PTPN21 UCKL1 UCKL1 PTPN12 PTPN12 PTPN23 PTPN23 TTF2 TTF2 PKP1 PKP1 PTPN14 PTPN14 CTNND1 CTNND1 ARVCF ARVCF PTPRD PTPRD PTPRM PTPRM PTPRA PTPRA PTPRG PTPRG CTNNB1 CTNNB1 JUP JUP PTPN4 PTPN4 PKP2 PKP2 PTPN13 PTPN13 PCDHB1 PCDHB1 PTPRZ1 PTPRZ1 CTNND2 CTNND2 PKP4 PKP4 PTPRN2 PTPRN2 PKP3 PKP3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small protein node
small nodes:
protein of unknown 3D structure
large protein node
large nodes:
some 3D structure is known or predicted
Node Color
colored protein node
colored nodes:
query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
database edge
from curated databases
experiment edge
experimentally determined
Predicted Interactions
neighborhood edge
gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
Others
textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
Your Input:
PKP2plakophilin 2; May play a role in junctional plaques (881 aa)
PTPN12protein tyrosine phosphatase, non-receptor type 12; Dephosphorylates cellular tyrosine kinases, including PTK2B/PYK2, and thereby regulates signaling via PTK2B/PYK2 (780 aa)
ARVCFarmadillo repeat gene deleted in velocardiofacial syndrome; Involved in protein-protein interactions at adherens junctions (962 aa)
PTPN4protein tyrosine phosphatase, non-receptor type 4 (megakaryocyte); May act at junctions between the membrane and the cytoskeleton (926 aa)
PKP1plakophilin 1 (ectodermal dysplasia/skin fragility syndrome); Seems to play a role in junctional plaques. Contributes to epidermal morphogenesis (747 aa)
PTPN23protein tyrosine phosphatase, non-receptor type 23; May act as a negative regulator of Ras-mediated mitogenic activity. Plays a role in ciliogenesis (1636 aa)
CTNND2catenin (cadherin-associated protein), delta 2 (1225 aa)
PCDHB1protocadherin beta 1; Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain (818 aa)
JUPjunction plakoglobin; Common junctional plaque protein. The membrane- associated plaques are architectural elements in an important strategic position to influence the arrangement and function of both the cytoskeleton and the cells within the tissue. The presence of plakoglobin in both the desmosomes and in the intermediate junctions suggests that it plays a central role in the structure and function of submembranous plaques. Acts as a substrate for VE-PTP and is required by it to stimulate VE- cadherin function in endothelial cells. Can replace beta-catenin in E-cadherin/catenin adhes [...] (745 aa)
PTPN21protein tyrosine phosphatase, non-receptor type 21 (1174 aa)
PTPRMprotein tyrosine phosphatase, receptor type, M; Involved in cell-cell adhesion through homophilic interactions. May play a key role in signal transduction and growth control (1452 aa)
PKP3plakophilin 3; May play a role in junctional plaques (797 aa)
CTNNB1catenin (cadherin-associated protein), beta 1, 88kDa; Key downstream component of the canonical Wnt signaling pathway. In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome. In the presence of Wnt ligand, CTNNB1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activate Wnt responsive genes. Involved in the regulation [...] (781 aa)
UCKL1uridine-cytidine kinase 1-like 1; May contribute to UTP accumulation needed for blast transformation and proliferation (548 aa)
PTPRDprotein tyrosine phosphatase, receptor type, D (1912 aa)
PTPN14protein tyrosine phosphatase, non-receptor type 14; Protein tyrosine phosphatase which may play a role in the regulation of lymphangiogenesis, cell-cell adhesion, cell- matrix adhesion, cell migration, cell growth and also regulates TGF-beta gene expression, thereby modulating epithelial- mesenchymal transition. Mediates beta-catenin dephosphorylation at adhesion junctions. Acts as a negative regulator of the oncogenic property of YAP, a downstream target of the hippo pathway, in a cell density-dependent manner. May function as a tumor suppressor (1187 aa)
TTF2transcription termination factor, RNA polymerase II; DsDNA-dependent ATPase which acts as a transcription termination factor by coupling ATP hydrolysis with removal of RNA polymerase II from the DNA template. May contribute to mitotic transcription repression. May also be involved in pre-mRNA splicing (1162 aa)
UPRTuracil phosphoribosyltransferase (FUR1) homolog (S. cerevisiae) (309 aa)
PTPN20Bprotein tyrosine phosphatase, non-receptor type 20B (420 aa)
PTPRAprotein tyrosine phosphatase, receptor type, A (802 aa)
PTPRN2protein tyrosine phosphatase, receptor type, N polypeptide 2; Implicated in development of nervous system and pancreatic endocrine cells (1015 aa)
PKP4plakophilin 4; Plays a role as a regulator of Rho activity during cytokinesis. May play a role in junctional plaques (1192 aa)
PTPRZ1protein tyrosine phosphatase, receptor-type, Z polypeptide 1; May be involved in the regulation of specific developmental processes in the CNS (2315 aa)
CTNND1catenin (cadherin-associated protein), delta 1 (968 aa)
PTPN13protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase) (2490 aa)
PTPRGprotein tyrosine phosphatase, receptor type, G; Possesses tyrosine phosphatase activity (1445 aa)
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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