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SPTBN4 | spectrin, beta, non-erythrocytic 4 (2564 aa) | |||
CALM2 | calmodulin 2 (phosphorylase kinase, delta) (149 aa) | |||
SCN2B | sodium channel, voltage-gated, type II, beta subunit; Crucial in the assembly, expression, and functional modulation of the heterotrimeric complex of the sodium channel. The subunit beta-2 causes an increase in the plasma membrane surface area and in its folding into microvilli. Interacts with TNR may play a crucial role in clustering and regulation of activity of sodium channels at nodes of Ranvier (By similarity) (215 aa) | |||
SCN3A | sodium channel, voltage-gated, type III, alpha subunit (2000 aa) | |||
SCN2A | sodium channel, voltage-gated, type II, alpha subunit; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient (2005 aa) | |||
CALM3 | calmodulin 3 (phosphorylase kinase, delta) (149 aa) | |||
SCN3B | sodium channel, voltage-gated, type III, beta subunit; Modulates channel gating kinetics. Causes unique persistent sodium currents. Inactivates the sodium channel opening more slowly than the subunit beta-1. Its association with neurofascin may target the sodium channels to the nodes of Ranvier of developing axons and retain these channels at the nodes in mature myelinated axons (By similarity) (215 aa) | |||
SCN1A | sodium channel, voltage-gated, type I, alpha subunit; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient (2009 aa) | |||
SCN11A | sodium channel, voltage-gated, type XI, alpha subunit; This protein mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which sodium ions may pass in accordance with their electrochemical gradient. It is a tetrodotoxin-resistant sodium channel isoform. Also involved, with the contribution of the receptor tyrosine kinase NTRK2, in rapid BDNF-evoked neuronal depolarization (1791 aa) | |||
SPTBN2 | spectrin, beta, non-erythrocytic 2; Probably plays an important role in neuronal membrane skeleton (2390 aa) | |||
SPTBN5 | spectrin, beta, non-erythrocytic 5 (3674 aa) | |||
CACNB2 | calcium channel, voltage-dependent, beta 2 subunit (660 aa) | |||
SCN4B | sodium channel, voltage-gated, type IV, beta subunit; Modulates channel gating kinetics. Causes negative shifts in the voltage dependence of activation of certain alpha sodium channels, but does not affect the voltage dependence of inactivation (By similarity) (228 aa) | |||
SCN5A | sodium channel, voltage-gated, type V, alpha subunit (2016 aa) | |||
NFASC | neurofascin (1240 aa) | |||
SCN8A | sodium channel, voltage gated, type VIII, alpha subunit; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. In macrophages and melanoma cells, isoform 5 may participate in the control of podosome and invadopodia formation (1980 aa) | |||
SPTBN1 | spectrin, beta, non-erythrocytic 1; Fodrin, which seems to be involved in secretion, interacts with calmodulin in a calcium-dependent manner and is thus candidate for the calcium-dependent movement of the cytoskeleton at the membrane (2364 aa) | |||
CALM1 | calmodulin 1 (phosphorylase kinase, delta) (149 aa) | |||
SPTA1 | spectrin, alpha, erythrocytic 1 (elliptocytosis 2); Spectrin is the major constituent of the cytoskeletal network underlying the erythrocyte plasma membrane. It associates with band 4.1 and actin to form the cytoskeletal superstructure of the erythrocyte plasma membrane (2419 aa) | |||
SPTAN1 | spectrin, alpha, non-erythrocytic 1 (2477 aa) | |||
NRCAM | neuronal cell adhesion molecule; Cell adhesion, ankyrin-binding protein involved in neuron-neuron adhesion. May play a role in the molecular assembly of the nodes of Ranvier (By similarity) (1304 aa) | |||
SPTB | spectrin, beta, erythrocytic; Spectrin is the major constituent of the cytoskeletal network underlying the erythrocyte plasma membrane. It associates with band 4.1 and actin to form the cytoskeletal superstructure of the erythrocyte plasma membrane (2328 aa) | |||
SCN9A | sodium channel, voltage-gated, type IX, alpha subunit (1977 aa) | |||
SCN10A | sodium channel, voltage-gated, type X, alpha subunit; This protein mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which sodium ions may pass in accordance with their electrochemical gradient. It is a tetrodotoxin-resistant sodium channel isoform. Its electrophysiological properties vary depending on the type of the associated beta subunits (in vitro). Plays a role in neuropathic pain mechanisms (By similarity) (1956 aa) | |||
SCN4A | sodium channel, voltage-gated, type IV, alpha subunit; This protein mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. This sodium channel may be present in both denervated and innervated skeletal muscle (1836 aa) | |||
SCN1B | sodium channel, voltage-gated, type I, beta subunit; Crucial in the assembly, expression, and functional modulation of the heterotrimeric complex of the sodium channel. The subunit beta-1 can modulate multiple alpha subunit isoforms from brain, skeletal muscle, and heart. Its association with neurofascin may target the sodium channels to the nodes of Ranvier of developing axons and retain these channels at the nodes in mature myelinated axons (268 aa) |