| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| AES | TLE1 | ENSP00000221561 | ENSP00000365682 | amino-terminal enhancer of split; Acts as dominant repressor towards other family members. Inhibits NF-kappa-B-regulated gene expression. May be required for the initiation and maintenance of the differentiated state | transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila); Transcriptional corepressor that binds to a number of transcription factors. Inhibits NF-kappa-B-regulated gene expression. Inhibits the transcriptional activation mediated by FOXA2, and by CTNNB1 and TCF family members in Wnt signaling. The effects of full-length TLE family members may be modulated by association with dominant-negative AES. Unusual function as coactivator for ESRRG | 0.975 |
| AES | TLE6 | ENSP00000221561 | ENSP00000246112 | amino-terminal enhancer of split; Acts as dominant repressor towards other family members. Inhibits NF-kappa-B-regulated gene expression. May be required for the initiation and maintenance of the differentiated state | transducin-like enhancer of split 6 (E(sp1) homolog, Drosophila); As a member of the subcortical maternal complex (SCMC), plays an essential role for zygotes to progress beyond the first embryonic cell divisions (By similarity) | 0.610 |
| ATN1 | ZNF608 | ENSP00000349076 | ENSP00000307746 | atrophin 1; Transcriptional corepressor. Recruits NR2E1 to repress transcription. Promotes vascular smooth cell (VSMC) migration and orientation (By similarity). Corepressor of MTG8 transcriptional repression. Has some intrinsic repression activity which is independent of the number of poly-Asn (polyQ) repeats | zinc finger protein 608 | 0.801 |
| EZR | MSN | ENSP00000338934 | ENSP00000353408 | ezrin; Probably involved in connections of major cytoskeletal structures to the plasma membrane. In epithelial cells, required for the formation of microvilli and membrane ruffles on the apical pole. Along with PLEKHG6, required for normal macropinocytosis | moesin; Probably involved in connections of major cytoskeletal structures to the plasma membrane. May inhibit herpes simplex virus 1 infection at an early stage | 0.936 |
| EZR | NF2 | ENSP00000338934 | ENSP00000344666 | ezrin; Probably involved in connections of major cytoskeletal structures to the plasma membrane. In epithelial cells, required for the formation of microvilli and membrane ruffles on the apical pole. Along with PLEKHG6, required for normal macropinocytosis | neurofibromin 2 (merlin) | 0.821 |
| EZR | RDX | ENSP00000338934 | ENSP00000342830 | ezrin; Probably involved in connections of major cytoskeletal structures to the plasma membrane. In epithelial cells, required for the formation of microvilli and membrane ruffles on the apical pole. Along with PLEKHG6, required for normal macropinocytosis | radixin; Probably plays a crucial role in the binding of the barbed end of actin filaments to the plasma membrane | 0.867 |
| MSN | EZR | ENSP00000353408 | ENSP00000338934 | moesin; Probably involved in connections of major cytoskeletal structures to the plasma membrane. May inhibit herpes simplex virus 1 infection at an early stage | ezrin; Probably involved in connections of major cytoskeletal structures to the plasma membrane. In epithelial cells, required for the formation of microvilli and membrane ruffles on the apical pole. Along with PLEKHG6, required for normal macropinocytosis | 0.936 |
| NF2 | EZR | ENSP00000344666 | ENSP00000338934 | neurofibromin 2 (merlin) | ezrin; Probably involved in connections of major cytoskeletal structures to the plasma membrane. In epithelial cells, required for the formation of microvilli and membrane ruffles on the apical pole. Along with PLEKHG6, required for normal macropinocytosis | 0.821 |
| RDX | EZR | ENSP00000342830 | ENSP00000338934 | radixin; Probably plays a crucial role in the binding of the barbed end of actin filaments to the plasma membrane | ezrin; Probably involved in connections of major cytoskeletal structures to the plasma membrane. In epithelial cells, required for the formation of microvilli and membrane ruffles on the apical pole. Along with PLEKHG6, required for normal macropinocytosis | 0.867 |
| TLE1 | AES | ENSP00000365682 | ENSP00000221561 | transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila); Transcriptional corepressor that binds to a number of transcription factors. Inhibits NF-kappa-B-regulated gene expression. Inhibits the transcriptional activation mediated by FOXA2, and by CTNNB1 and TCF family members in Wnt signaling. The effects of full-length TLE family members may be modulated by association with dominant-negative AES. Unusual function as coactivator for ESRRG | amino-terminal enhancer of split; Acts as dominant repressor towards other family members. Inhibits NF-kappa-B-regulated gene expression. May be required for the initiation and maintenance of the differentiated state | 0.975 |
| TLE1 | TLE2 | ENSP00000365682 | ENSP00000262953 | transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila); Transcriptional corepressor that binds to a number of transcription factors. Inhibits NF-kappa-B-regulated gene expression. Inhibits the transcriptional activation mediated by FOXA2, and by CTNNB1 and TCF family members in Wnt signaling. The effects of full-length TLE family members may be modulated by association with dominant-negative AES. Unusual function as coactivator for ESRRG | transducin-like enhancer of split 2 (E(sp1) homolog, Drosophila); Transcriptional corepressor that binds to a number of transcription factors. Inhibits the transcriptional activation mediated by CTNNB1 and TCF family members in Wnt signaling. The effects of full-length TLE family members may be modulated by association with dominant-negative AES (By similarity) | 0.956 |
| TLE1 | TLE4 | ENSP00000365682 | ENSP00000365735 | transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila); Transcriptional corepressor that binds to a number of transcription factors. Inhibits NF-kappa-B-regulated gene expression. Inhibits the transcriptional activation mediated by FOXA2, and by CTNNB1 and TCF family members in Wnt signaling. The effects of full-length TLE family members may be modulated by association with dominant-negative AES. Unusual function as coactivator for ESRRG | transducin-like enhancer of split 4 (E(sp1) homolog, Drosophila) | 0.901 |
| TLE1 | ZNF608 | ENSP00000365682 | ENSP00000307746 | transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila); Transcriptional corepressor that binds to a number of transcription factors. Inhibits NF-kappa-B-regulated gene expression. Inhibits the transcriptional activation mediated by FOXA2, and by CTNNB1 and TCF family members in Wnt signaling. The effects of full-length TLE family members may be modulated by association with dominant-negative AES. Unusual function as coactivator for ESRRG | zinc finger protein 608 | 0.479 |
| TLE2 | TLE1 | ENSP00000262953 | ENSP00000365682 | transducin-like enhancer of split 2 (E(sp1) homolog, Drosophila); Transcriptional corepressor that binds to a number of transcription factors. Inhibits the transcriptional activation mediated by CTNNB1 and TCF family members in Wnt signaling. The effects of full-length TLE family members may be modulated by association with dominant-negative AES (By similarity) | transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila); Transcriptional corepressor that binds to a number of transcription factors. Inhibits NF-kappa-B-regulated gene expression. Inhibits the transcriptional activation mediated by FOXA2, and by CTNNB1 and TCF family members in Wnt signaling. The effects of full-length TLE family members may be modulated by association with dominant-negative AES. Unusual function as coactivator for ESRRG | 0.956 |
| TLE2 | TLE4 | ENSP00000262953 | ENSP00000365735 | transducin-like enhancer of split 2 (E(sp1) homolog, Drosophila); Transcriptional corepressor that binds to a number of transcription factors. Inhibits the transcriptional activation mediated by CTNNB1 and TCF family members in Wnt signaling. The effects of full-length TLE family members may be modulated by association with dominant-negative AES (By similarity) | transducin-like enhancer of split 4 (E(sp1) homolog, Drosophila) | 0.901 |
| TLE2 | ZNF608 | ENSP00000262953 | ENSP00000307746 | transducin-like enhancer of split 2 (E(sp1) homolog, Drosophila); Transcriptional corepressor that binds to a number of transcription factors. Inhibits the transcriptional activation mediated by CTNNB1 and TCF family members in Wnt signaling. The effects of full-length TLE family members may be modulated by association with dominant-negative AES (By similarity) | zinc finger protein 608 | 0.465 |
| TLE3 | ZNF608 | ENSP00000452871 | ENSP00000307746 | transducin-like enhancer of split 3 (E(sp1) homolog, Drosophila); Transcriptional corepressor that binds to a number of transcription factors. Inhibits the transcriptional activation mediated by CTNNB1 and TCF family members in Wnt signaling. The effects of full-length TLE family members may be modulated by association with dominant-negative AES (By similarity) | zinc finger protein 608 | 0.479 |
| TLE4 | TLE1 | ENSP00000365735 | ENSP00000365682 | transducin-like enhancer of split 4 (E(sp1) homolog, Drosophila) | transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila); Transcriptional corepressor that binds to a number of transcription factors. Inhibits NF-kappa-B-regulated gene expression. Inhibits the transcriptional activation mediated by FOXA2, and by CTNNB1 and TCF family members in Wnt signaling. The effects of full-length TLE family members may be modulated by association with dominant-negative AES. Unusual function as coactivator for ESRRG | 0.901 |
| TLE4 | TLE2 | ENSP00000365735 | ENSP00000262953 | transducin-like enhancer of split 4 (E(sp1) homolog, Drosophila) | transducin-like enhancer of split 2 (E(sp1) homolog, Drosophila); Transcriptional corepressor that binds to a number of transcription factors. Inhibits the transcriptional activation mediated by CTNNB1 and TCF family members in Wnt signaling. The effects of full-length TLE family members may be modulated by association with dominant-negative AES (By similarity) | 0.901 |
| TLE4 | ZNF608 | ENSP00000365735 | ENSP00000307746 | transducin-like enhancer of split 4 (E(sp1) homolog, Drosophila) | zinc finger protein 608 | 0.480 |
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