node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ACAN | CHST2 | ENSP00000387356 | ENSP00000307911 | aggrecan; This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region | carbohydrate (N-acetylglucosamine-6-O) sulfotransferase 2; Sulfotransferase that utilizes 3’-phospho-5’-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the transfer of sulfate to position 6 of non-reducing N-acetylglucosamine (GlcNAc) residues within keratan-like structures on N-linked glycans and within mucin-associated glycans that can ultimately serve as SELL ligands. SELL ligands are present in high endothelial cells (HEVs) and play a central role in lymphocyte homing at sites of inflammation. Participates in biosynthesis of the SELL ligand sialyl 6-sulfo Lewis X and in lymp [...] | 0.910 |
ACAN | FMOD | ENSP00000387356 | ENSP00000347041 | aggrecan; This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region | fibromodulin; Affects the rate of fibrils formation. May have a primary role in collagen fibrillogenesis (By similarity) | 0.971 |
ACAN | KERA | ENSP00000387356 | ENSP00000266719 | aggrecan; This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region | keratocan; May be important in developing and maintaining corneal transparency and for the structure of the stromal matrix | 0.944 |
ACAN | LUM | ENSP00000387356 | ENSP00000266718 | aggrecan; This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region | lumican | 0.996 |
ACAN | OGN | ENSP00000387356 | ENSP00000262551 | aggrecan; This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region | osteoglycin; Induces bone formation in conjunction with TGF-beta-1 or TGF-beta-2 | 0.930 |
ACAN | OMD | ENSP00000387356 | ENSP00000364700 | aggrecan; This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region | osteomodulin; May be implicated in biomineralization processes. Has a function in binding of osteoblasts via the alpha(V)beta(3)- integrin (By similarity) | 0.929 |
ACAN | PRELP | ENSP00000387356 | ENSP00000343924 | aggrecan; This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region | proline/arginine-rich end leucine-rich repeat protein; May anchor basement membranes to the underlying connective tissue (By similarity) | 0.948 |
CHST2 | ACAN | ENSP00000307911 | ENSP00000387356 | carbohydrate (N-acetylglucosamine-6-O) sulfotransferase 2; Sulfotransferase that utilizes 3’-phospho-5’-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the transfer of sulfate to position 6 of non-reducing N-acetylglucosamine (GlcNAc) residues within keratan-like structures on N-linked glycans and within mucin-associated glycans that can ultimately serve as SELL ligands. SELL ligands are present in high endothelial cells (HEVs) and play a central role in lymphocyte homing at sites of inflammation. Participates in biosynthesis of the SELL ligand sialyl 6-sulfo Lewis X and in lymp [...] | aggrecan; This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region | 0.910 |
CHST2 | FMOD | ENSP00000307911 | ENSP00000347041 | carbohydrate (N-acetylglucosamine-6-O) sulfotransferase 2; Sulfotransferase that utilizes 3’-phospho-5’-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the transfer of sulfate to position 6 of non-reducing N-acetylglucosamine (GlcNAc) residues within keratan-like structures on N-linked glycans and within mucin-associated glycans that can ultimately serve as SELL ligands. SELL ligands are present in high endothelial cells (HEVs) and play a central role in lymphocyte homing at sites of inflammation. Participates in biosynthesis of the SELL ligand sialyl 6-sulfo Lewis X and in lymp [...] | fibromodulin; Affects the rate of fibrils formation. May have a primary role in collagen fibrillogenesis (By similarity) | 0.900 |
CHST2 | KERA | ENSP00000307911 | ENSP00000266719 | carbohydrate (N-acetylglucosamine-6-O) sulfotransferase 2; Sulfotransferase that utilizes 3’-phospho-5’-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the transfer of sulfate to position 6 of non-reducing N-acetylglucosamine (GlcNAc) residues within keratan-like structures on N-linked glycans and within mucin-associated glycans that can ultimately serve as SELL ligands. SELL ligands are present in high endothelial cells (HEVs) and play a central role in lymphocyte homing at sites of inflammation. Participates in biosynthesis of the SELL ligand sialyl 6-sulfo Lewis X and in lymp [...] | keratocan; May be important in developing and maintaining corneal transparency and for the structure of the stromal matrix | 0.900 |
CHST2 | LUM | ENSP00000307911 | ENSP00000266718 | carbohydrate (N-acetylglucosamine-6-O) sulfotransferase 2; Sulfotransferase that utilizes 3’-phospho-5’-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the transfer of sulfate to position 6 of non-reducing N-acetylglucosamine (GlcNAc) residues within keratan-like structures on N-linked glycans and within mucin-associated glycans that can ultimately serve as SELL ligands. SELL ligands are present in high endothelial cells (HEVs) and play a central role in lymphocyte homing at sites of inflammation. Participates in biosynthesis of the SELL ligand sialyl 6-sulfo Lewis X and in lymp [...] | lumican | 0.941 |
CHST2 | OGN | ENSP00000307911 | ENSP00000262551 | carbohydrate (N-acetylglucosamine-6-O) sulfotransferase 2; Sulfotransferase that utilizes 3’-phospho-5’-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the transfer of sulfate to position 6 of non-reducing N-acetylglucosamine (GlcNAc) residues within keratan-like structures on N-linked glycans and within mucin-associated glycans that can ultimately serve as SELL ligands. SELL ligands are present in high endothelial cells (HEVs) and play a central role in lymphocyte homing at sites of inflammation. Participates in biosynthesis of the SELL ligand sialyl 6-sulfo Lewis X and in lymp [...] | osteoglycin; Induces bone formation in conjunction with TGF-beta-1 or TGF-beta-2 | 0.903 |
CHST2 | OMD | ENSP00000307911 | ENSP00000364700 | carbohydrate (N-acetylglucosamine-6-O) sulfotransferase 2; Sulfotransferase that utilizes 3’-phospho-5’-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the transfer of sulfate to position 6 of non-reducing N-acetylglucosamine (GlcNAc) residues within keratan-like structures on N-linked glycans and within mucin-associated glycans that can ultimately serve as SELL ligands. SELL ligands are present in high endothelial cells (HEVs) and play a central role in lymphocyte homing at sites of inflammation. Participates in biosynthesis of the SELL ligand sialyl 6-sulfo Lewis X and in lymp [...] | osteomodulin; May be implicated in biomineralization processes. Has a function in binding of osteoblasts via the alpha(V)beta(3)- integrin (By similarity) | 0.900 |
CHST2 | PRELP | ENSP00000307911 | ENSP00000343924 | carbohydrate (N-acetylglucosamine-6-O) sulfotransferase 2; Sulfotransferase that utilizes 3’-phospho-5’-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the transfer of sulfate to position 6 of non-reducing N-acetylglucosamine (GlcNAc) residues within keratan-like structures on N-linked glycans and within mucin-associated glycans that can ultimately serve as SELL ligands. SELL ligands are present in high endothelial cells (HEVs) and play a central role in lymphocyte homing at sites of inflammation. Participates in biosynthesis of the SELL ligand sialyl 6-sulfo Lewis X and in lymp [...] | proline/arginine-rich end leucine-rich repeat protein; May anchor basement membranes to the underlying connective tissue (By similarity) | 0.903 |
CHST4 | LUM | ENSP00000341206 | ENSP00000266718 | carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 4; Sulfotransferase that utilizes 3’-phospho-5’-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the transfer of sulfate to position 6 of non-reducing N-acetylglucosamine (GlcNAc) residues within mucin-associated glycans that ultimately serve as SELL ligands. SELL ligands are present in high endothelial cells (HEVs) and play a central role in lymphocyte homing at sites of inflammation. Participates in biosynthesis of the SELL ligand sialyl 6-sulfo Lewis X on receptors SPN/CD43, GLYCAM1 and MADCAM1. Also involved in biosynthe [...] | lumican | 0.459 |
FMOD | ACAN | ENSP00000347041 | ENSP00000387356 | fibromodulin; Affects the rate of fibrils formation. May have a primary role in collagen fibrillogenesis (By similarity) | aggrecan; This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region | 0.971 |
FMOD | CHST2 | ENSP00000347041 | ENSP00000307911 | fibromodulin; Affects the rate of fibrils formation. May have a primary role in collagen fibrillogenesis (By similarity) | carbohydrate (N-acetylglucosamine-6-O) sulfotransferase 2; Sulfotransferase that utilizes 3’-phospho-5’-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the transfer of sulfate to position 6 of non-reducing N-acetylglucosamine (GlcNAc) residues within keratan-like structures on N-linked glycans and within mucin-associated glycans that can ultimately serve as SELL ligands. SELL ligands are present in high endothelial cells (HEVs) and play a central role in lymphocyte homing at sites of inflammation. Participates in biosynthesis of the SELL ligand sialyl 6-sulfo Lewis X and in lymp [...] | 0.900 |
FMOD | KERA | ENSP00000347041 | ENSP00000266719 | fibromodulin; Affects the rate of fibrils formation. May have a primary role in collagen fibrillogenesis (By similarity) | keratocan; May be important in developing and maintaining corneal transparency and for the structure of the stromal matrix | 0.908 |
FMOD | LUM | ENSP00000347041 | ENSP00000266718 | fibromodulin; Affects the rate of fibrils formation. May have a primary role in collagen fibrillogenesis (By similarity) | lumican | 0.916 |
FMOD | OGN | ENSP00000347041 | ENSP00000262551 | fibromodulin; Affects the rate of fibrils formation. May have a primary role in collagen fibrillogenesis (By similarity) | osteoglycin; Induces bone formation in conjunction with TGF-beta-1 or TGF-beta-2 | 0.921 |