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DDX52 DDX52 TBL3 TBL3 RBM19 RBM19 CIRH1A CIRH1A UTP15 UTP15 NOP14 NOP14 PNO1 PNO1 RRP9 RRP9 PWP2 PWP2 HEATR1 HEATR1 UTP18 UTP18 IMP3 IMP3 UTP6 UTP6 BYSL BYSL WDR75 WDR75 WDR3 WDR3 MPHOSPH10 MPHOSPH10 NOL6 NOL6 DCAF13 DCAF13 NOC4L NOC4L UTP20 UTP20 BMS1 BMS1 NOL10 NOL10 DHX37 DHX37 WDR36 WDR36 UBC UBC
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small protein node
small nodes:
protein of unknown 3D structure
large protein node
large nodes:
some 3D structure is known or predicted
Node Color
colored protein node
colored nodes:
query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
database edge
from curated databases
experiment edge
experimentally determined
Predicted Interactions
neighborhood edge
gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
Others
textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
Your Input:
UTP18UTP18 small subunit (SSU) processome component homolog (yeast); Involved in nucleolar processing of pre-18S ribosomal RNA (By similarity) (556 aa)
BYSLbystin-like; Required for processing of 20S pre-rRNA precursor and biogenesis of 40S ribosomal subunits. May be required for trophinin-dependent regulation of cell adhesion during implantation of human embryos (437 aa)
RRP9ribosomal RNA processing 9, small subunit (SSU) processome component, homolog (yeast); Component of a nucleolar small nuclear ribonucleoprotein particle (snoRNP) thought to participate in the processing and modification of pre-ribosomal RNA (475 aa)
MPHOSPH10M-phase phosphoprotein 10 (U3 small nucleolar ribonucleoprotein); Component of the 60-80S U3 small nucleolar ribonucleoprotein (U3 snoRNP). Required for the early cleavages during pre-18S ribosomal RNA processing (681 aa)
UTP20UTP20, small subunit (SSU) processome component, homolog (yeast); Involved in 18S pre-rRNA processing. Associates with U3 snoRNA (2785 aa)
UTP6UTP6, small subunit (SSU) processome component, homolog (yeast); Involved in nucleolar processing of pre-18S ribosomal RNA (By similarity) (597 aa)
RBM19RNA binding motif protein 19; Plays a role in embryo pre-implantation development (By similarity) (960 aa)
PNO1partner of NOB1 homolog (S. cerevisiae) (252 aa)
DDX52DEAD (Asp-Glu-Ala-Asp) box polypeptide 52 (599 aa)
PWP2PWP2 periodic tryptophan protein homolog (yeast) (919 aa)
UTP15UTP15, U3 small nucleolar ribonucleoprotein, homolog (S. cerevisiae); Involved in nucleolar processing of pre-18S ribosomal RNA (By similarity) (518 aa)
DCAF13DDB1 and CUL4 associated factor 13; Possible role in ribosomal RNA processing (By similarity). May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex (597 aa)
NOL6nucleolar protein family 6 (RNA-associated) (1146 aa)
WDR3WD repeat domain 3 (943 aa)
DHX37DEAH (Asp-Glu-Ala-His) box polypeptide 37 (1157 aa)
WDR75WD repeat domain 75 (830 aa)
NOP14NOP14 nucleolar protein homolog (yeast); Involved in nucleolar processing of pre-18S ribosomal RNA. Has a role in the nuclear export of 40S pre-ribosomal subunit to the cytoplasm (By similarity) (857 aa)
IMP3IMP3, U3 small nucleolar ribonucleoprotein, homolog (yeast); Component of the 60-80S U3 small nucleolar ribonucleoprotein (U3 snoRNP). Required for the early cleavages during pre-18S ribosomal RNA processing (184 aa)
CIRH1Acirrhosis, autosomal recessive 1A (cirhin); May be a transcriptional regulator. Acts as a positive regulator of HIVEP1 which specifically binds to the DNA sequence 5’-GGGACTTTCC-3’ found in enhancer elements of numerous viral promoters such as those of HIV-1, SV40, or CMV (686 aa)
NOC4Lnucleolar complex associated 4 homolog (S. cerevisiae) (516 aa)
UBCubiquitin C (685 aa)
HEATR1HEAT repeat containing 1; Involved in nucleolar processing of pre-18S ribosomal RNA. Involved in ribosome biosynthesis (By similarity) (2144 aa)
BMS1BMS1 homolog, ribosome assembly protein (yeast); May act as a molecular switch during maturation of the 40S ribosomal subunit in the nucleolus (By similarity) (1282 aa)
NOL10nucleolar protein 10 (688 aa)
WDR36WD repeat domain 36; Involved in T-cell activation and highly co-regulated with IL2 (951 aa)
TBL3transducin (beta)-like 3 (808 aa)
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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