26 items (Homo sapiens) - STRING network view

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	MAP2K5	mitogen-activated protein kinase kinase 5; Acts as a scaffold for the formation of a ternary MAP3K2/MAP3K3-MAP3K5-MAPK7 signaling complex. Activation of this pathway appears to play a critical role in protecting cells from stress-induced apoptosis, neuronal survival and cardiac development and angiogenesis (448 aa)
	RIPK3	receptor-interacting serine-threonine kinase 3; Essential for programmed necrosis in response to death- inducing TNF-alpha family members. Upon induction of necrosis, RIPK3 interacts with, and phosphorylates RIPK1 to form a necrosis- inducing complex. RIPK3 binds to and enhances the activity of three metabolic enzymes- GLUL, GLUD1, and PYGL. These metabolic enzymes may eventually stimulate the tricarboxylic acid cycle and oxidative phosphorylation, which could result in enhanced ROS production (By similarity) (518 aa)
	UMPS	uridine monophosphate synthetase (480 aa)
	PHLPP1	PH domain and leucine rich repeat protein phosphatase 1; Protein phosphatase that mediates dephosphorylation of ’Ser-473’ of AKT1, ’Ser-660’ of PRKCB isoform beta-II and ’Ser- 657’ of PRKCA. AKT1 regulates the balance between cell survival and apoptosis through a cascade that primarily alters the function of transcription factors that regulate pro- and antiapoptotic genes. Dephosphorylation of ’Ser-473’ of AKT1 triggers apoptosis and suppression of tumor growth. Controls the phosphorylation of AKT2 and AKT3 more efficiently than that of AKT1. Dephosphorylation of PRKCA and PRKCB leads [...] (1717 aa)
	HACE1	HECT domain and ankyrin repeat containing E3 ubiquitin protein ligase 1 (909 aa)
	MAP2K2	mitogen-activated protein kinase kinase 2; Catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in a Thr-Glu-Tyr sequence located in MAP kinases. Activates the ERK1 and ERK2 MAP kinases (By similarity) (400 aa)
	SMARCA2	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2; Transcriptional coactivator cooperating with nuclear hormone receptors to potentiate transcriptional activation. Also involved in vitamin D-coupled transcription regulation via its association with the WINAC complex, a chromatin-remodeling complex recruited by vitamin D receptor (VDR), which is required for the ligand-bound VDR-mediated transrepression of the CYP27B1 gene. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chrom [...] (1590 aa)
	LRRK2	leucine-rich repeat kinase 2; May play a role in the phosphorylation of proteins central to Parkinson disease. Phosphorylates PRDX3. May also have GTPase activity. Positively regulates autophagy through a calcium- dependent activation of the CaMKK/AMPK signaling pathway. The process involves activation of nicotinic acid adenine dinucleotide phosphate (NAADP) receptors, increase in lysosomal pH, and calcium release from lysosomes (2527 aa)
	MAP2K1	mitogen-activated protein kinase kinase 1; Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Binding of extracellular ligands such as growth factors, cytokines and hormones to their cell-surface receptors activates RAS and this initiates RAF1 activation. RAF1 then further activates the dual-specificity protein kinases MAP2K1/MEK1 and MAP2K2/MEK2. Both MAP2K1/MEK1 and MAP2K2/MEK2 function specifically in the MAPK/ERK cascade, and catalyze the concomitant phosphorylation of a threonine and a tyrosine residue in a Thr-Glu-T [...] (393 aa)
	MLKL	mixed lineage kinase domain-like; Required for the execution of programmed necrosis (471 aa)
	PITPNA	phosphatidylinositol transfer protein, alpha; Catalyzes the transfer of PtdIns and phosphatidylcholine between membranes (270 aa)
	ACACB	acetyl-CoA carboxylase beta; ACC-beta may be involved in the provision of malonyl-CoA or in the regulation of fatty acid oxidation, rather than fatty acid biosynthesis. Carries out three functions- biotin carboxyl carrier protein, biotin carboxylase and carboxyltransferase (2458 aa)
	ACACA	acetyl-CoA carboxylase alpha (2383 aa)
	UBC	ubiquitin C (685 aa)
	PHLPP2	PH domain and leucine rich repeat protein phosphatase 2; Protein phosphatase that mediates dephosphorylation of ’Ser-473’ of AKT1, ’Ser-660’ of PRKCB isoform beta-II and ’Ser- 657’ of PRKCA. AKT1 regulates the balance between cell survival and apoptosis through a cascade that primarily alters the function of transcription factors that regulate pro- and antiapoptotic genes. Dephosphorylation of ’Ser-473’ of AKT1 triggers apoptosis and decreases cell proliferation. Also controls the phosphorylation of AKT3. Dephosphorylation of PRKCA and PRKCB leads to their destabilization and degradati [...] (1323 aa)
	POTEF	POTE ankyrin domain family, member F (1075 aa)
	SMARCA4	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4; Transcriptional coactivator cooperating with nuclear hormone receptors to potentiate transcriptional activation. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC repressor complex. Upon calcium influx, RB1 is dephos [...] (1679 aa)
	PBX2	pre-B-cell leukemia homeobox 2; Transcriptional activator that binds the sequence 5’- ATCAATCAA-3’. Activates transcription of PF4 in complex with MEIS1 (430 aa)
	PAICS	phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase (432 aa)
	POTEJ	POTE ankyrin domain family, member J (1038 aa)
	POTEI	POTE ankyrin domain family, member I (1075 aa)
	ZDHHC13	zinc finger, DHHC-type containing 13; Palmitoyltransferase for HD and GAD2 (By similarity). Mediates Mg(2+) transport (By similarity) (622 aa)
	ZDHHC17	zinc finger, DHHC-type containing 17; Palmitoyltransferase specific for a subset of neuronal proteins, including SNAP25, DLG4/PSD95, GAD2, SYT1 and HD. Palmitoylates MPP1 in erythrocytes. May be involved in the sorting or targeting of critical proteins involved in the initiating events of endocytosis at the plasma membrane. Has transforming activity. Mediates Mg(2+) transport (632 aa)
	PGAM5	phosphoglycerate mutase family member 5; Displays phosphatase activity for serine/threonine residues, and, dephosphorylates and activates MAP3K5 kinase. Has apparently no phosphoglycerate mutase activity. May be regulator of mitochondrial dynamics. Substrate for a KEAP1-dependent ubiquitin ligase complex. Contributes to the repression of NFE2L2- dependent gene expression. Acts as a central mediator for programmed necrosis induced by TNF, by reactive oxygen species and by calcium ionophore (289 aa)
	POTEE	POTE ankyrin domain family member E (1075 aa)
	ENSG00000258973	Uncharacterized protein (256 aa)

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACACA	ACACB	ENSP00000344789	ENSP00000341044	acetyl-CoA carboxylase alpha	acetyl-CoA carboxylase beta; ACC-beta may be involved in the provision of malonyl-CoA or in the regulation of fatty acid oxidation, rather than fatty acid biosynthesis. Carries out three functions- biotin carboxyl carrier protein, biotin carboxylase and carboxyltransferase	0.999
ACACA	ENSG00000258973	ENSP00000344789	ENSP00000450730	acetyl-CoA carboxylase alpha	Uncharacterized protein	0.481
ACACA	MLKL	ENSP00000344789	ENSP00000308351	acetyl-CoA carboxylase alpha	mixed lineage kinase domain-like; Required for the execution of programmed necrosis	0.481
ACACA	RIPK3	ENSP00000344789	ENSP00000216274	acetyl-CoA carboxylase alpha	receptor-interacting serine-threonine kinase 3; Essential for programmed necrosis in response to death- inducing TNF-alpha family members. Upon induction of necrosis, RIPK3 interacts with, and phosphorylates RIPK1 to form a necrosis- inducing complex. RIPK3 binds to and enhances the activity of three metabolic enzymes- GLUL, GLUD1, and PYGL. These metabolic enzymes may eventually stimulate the tricarboxylic acid cycle and oxidative phosphorylation, which could result in enhanced ROS production (By similarity)	0.481
ACACA	UBC	ENSP00000344789	ENSP00000344818	acetyl-CoA carboxylase alpha	ubiquitin C	0.922
ACACA	UMPS	ENSP00000344789	ENSP00000232607	acetyl-CoA carboxylase alpha	uridine monophosphate synthetase	0.632
ACACB	ACACA	ENSP00000341044	ENSP00000344789	acetyl-CoA carboxylase beta; ACC-beta may be involved in the provision of malonyl-CoA or in the regulation of fatty acid oxidation, rather than fatty acid biosynthesis. Carries out three functions- biotin carboxyl carrier protein, biotin carboxylase and carboxyltransferase	acetyl-CoA carboxylase alpha	0.999
ACACB	ENSG00000258973	ENSP00000341044	ENSP00000450730	acetyl-CoA carboxylase beta; ACC-beta may be involved in the provision of malonyl-CoA or in the regulation of fatty acid oxidation, rather than fatty acid biosynthesis. Carries out three functions- biotin carboxyl carrier protein, biotin carboxylase and carboxyltransferase	Uncharacterized protein	0.481
ACACB	MLKL	ENSP00000341044	ENSP00000308351	acetyl-CoA carboxylase beta; ACC-beta may be involved in the provision of malonyl-CoA or in the regulation of fatty acid oxidation, rather than fatty acid biosynthesis. Carries out three functions- biotin carboxyl carrier protein, biotin carboxylase and carboxyltransferase	mixed lineage kinase domain-like; Required for the execution of programmed necrosis	0.481
ACACB	RIPK3	ENSP00000341044	ENSP00000216274	acetyl-CoA carboxylase beta; ACC-beta may be involved in the provision of malonyl-CoA or in the regulation of fatty acid oxidation, rather than fatty acid biosynthesis. Carries out three functions- biotin carboxyl carrier protein, biotin carboxylase and carboxyltransferase	receptor-interacting serine-threonine kinase 3; Essential for programmed necrosis in response to death- inducing TNF-alpha family members. Upon induction of necrosis, RIPK3 interacts with, and phosphorylates RIPK1 to form a necrosis- inducing complex. RIPK3 binds to and enhances the activity of three metabolic enzymes- GLUL, GLUD1, and PYGL. These metabolic enzymes may eventually stimulate the tricarboxylic acid cycle and oxidative phosphorylation, which could result in enhanced ROS production (By similarity)	0.481
ACACB	UBC	ENSP00000341044	ENSP00000344818	acetyl-CoA carboxylase beta; ACC-beta may be involved in the provision of malonyl-CoA or in the regulation of fatty acid oxidation, rather than fatty acid biosynthesis. Carries out three functions- biotin carboxyl carrier protein, biotin carboxylase and carboxyltransferase	ubiquitin C	0.851
ACACB	UMPS	ENSP00000341044	ENSP00000232607	acetyl-CoA carboxylase beta; ACC-beta may be involved in the provision of malonyl-CoA or in the regulation of fatty acid oxidation, rather than fatty acid biosynthesis. Carries out three functions- biotin carboxyl carrier protein, biotin carboxylase and carboxyltransferase	uridine monophosphate synthetase	0.635
ENSG00000258973	ACACA	ENSP00000450730	ENSP00000344789	Uncharacterized protein	acetyl-CoA carboxylase alpha	0.481
ENSG00000258973	ACACB	ENSP00000450730	ENSP00000341044	Uncharacterized protein	acetyl-CoA carboxylase beta; ACC-beta may be involved in the provision of malonyl-CoA or in the regulation of fatty acid oxidation, rather than fatty acid biosynthesis. Carries out three functions- biotin carboxyl carrier protein, biotin carboxylase and carboxyltransferase	0.481
ENSG00000258973	MLKL	ENSP00000450730	ENSP00000308351	Uncharacterized protein	mixed lineage kinase domain-like; Required for the execution of programmed necrosis	0.800
ENSG00000258973	PHLPP1	ENSP00000450730	ENSP00000262719	Uncharacterized protein	PH domain and leucine rich repeat protein phosphatase 1; Protein phosphatase that mediates dephosphorylation of ’Ser-473’ of AKT1, ’Ser-660’ of PRKCB isoform beta-II and ’Ser- 657’ of PRKCA. AKT1 regulates the balance between cell survival and apoptosis through a cascade that primarily alters the function of transcription factors that regulate pro- and antiapoptotic genes. Dephosphorylation of ’Ser-473’ of AKT1 triggers apoptosis and suppression of tumor growth. Controls the phosphorylation of AKT2 and AKT3 more efficiently than that of AKT1. Dephosphorylation of PRKCA and PRKCB leads [...]	0.788
ENSG00000258973	PHLPP2	ENSP00000450730	ENSP00000348611	Uncharacterized protein	PH domain and leucine rich repeat protein phosphatase 2; Protein phosphatase that mediates dephosphorylation of ’Ser-473’ of AKT1, ’Ser-660’ of PRKCB isoform beta-II and ’Ser- 657’ of PRKCA. AKT1 regulates the balance between cell survival and apoptosis through a cascade that primarily alters the function of transcription factors that regulate pro- and antiapoptotic genes. Dephosphorylation of ’Ser-473’ of AKT1 triggers apoptosis and decreases cell proliferation. Also controls the phosphorylation of AKT3. Dephosphorylation of PRKCA and PRKCB leads to their destabilization and degradati [...]	0.788
ENSG00000258973	UMPS	ENSP00000450730	ENSP00000232607	Uncharacterized protein	uridine monophosphate synthetase	0.542
HACE1	LRRK2	ENSP00000262903	ENSP00000298910	HECT domain and ankyrin repeat containing E3 ubiquitin protein ligase 1	leucine-rich repeat kinase 2; May play a role in the phosphorylation of proteins central to Parkinson disease. Phosphorylates PRDX3. May also have GTPase activity. Positively regulates autophagy through a calcium- dependent activation of the CaMKK/AMPK signaling pathway. The process involves activation of nicotinic acid adenine dinucleotide phosphate (NAADP) receptors, increase in lysosomal pH, and calcium release from lysosomes	0.519
HACE1	PHLPP1	ENSP00000262903	ENSP00000262719	HECT domain and ankyrin repeat containing E3 ubiquitin protein ligase 1	PH domain and leucine rich repeat protein phosphatase 1; Protein phosphatase that mediates dephosphorylation of ’Ser-473’ of AKT1, ’Ser-660’ of PRKCB isoform beta-II and ’Ser- 657’ of PRKCA. AKT1 regulates the balance between cell survival and apoptosis through a cascade that primarily alters the function of transcription factors that regulate pro- and antiapoptotic genes. Dephosphorylation of ’Ser-473’ of AKT1 triggers apoptosis and suppression of tumor growth. Controls the phosphorylation of AKT2 and AKT3 more efficiently than that of AKT1. Dephosphorylation of PRKCA and PRKCB leads [...]	0.722

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