Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small nodes:
protein of unknown 3D structure
protein of unknown 3D structure
large nodes:
some 3D structure is known or predicted
some 3D structure is known or predicted
Node Color
colored nodes:
query proteins and first shell of interactors
query proteins and first shell of interactors
white nodes:
second shell of interactors
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Your Input:
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 | ACR | acrosin; Acrosin is the major protease of mammalian spermatozoa. It is a serine protease of trypsin-like cleavage specificity, it is synthesized in a zymogen form, proacrosin and stored in the acrosome (421 aa) | ||
 | F9 | coagulation factor IX; Factor IX is a vitamin K-dependent plasma protein that participates in the intrinsic pathway of blood coagulation by converting factor X to its active form in the presence of Ca(2+) ions, phospholipids, and factor VIIIa (461 aa) | ||
 | PRSS54 | protease, serine, 54 (395 aa) | ||
 | PRSS37 | protease, serine, 37 (235 aa) | ||
 | FAM46D | family with sequence similarity 46, member D (389 aa) | ||
 | PRSS50 | protease, serine, 50; May be involved in proteolysis through its threonine endopeptidase activity (385 aa) | ||
 | PRSS55 | protease, serine, 55; Probable serine protease (By similarity) (352 aa) | ||
 | TMPRSS12 | transmembrane (C-terminal) protease, serine 12 (348 aa) | ||
 | PRSS46 | protease, serine, 46 (174 aa) | ||
 | C1orf94 | chromosome 1 open reading frame 94 (598 aa) | ||
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
Other names: H. sapiens, Homo, Homo sapiens, human, man
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