node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
COL18A1 | MMP1 | ENSP00000347665 | ENSP00000322788 | collagen, type XVIII, alpha 1 | matrix metallopeptidase 1 (interstitial collagenase); Cleaves collagens of types I, II, and III at one site in the helical domain. Also cleaves collagens of types VII and X. In case of HIV infection, interacts and cleaves the secreted viral Tat protein, leading to a decrease in neuronal Tat’s mediated neurotoxicity | 0.944 |
COL18A1 | MMP7 | ENSP00000347665 | ENSP00000260227 | collagen, type XVIII, alpha 1 | matrix metallopeptidase 7 (matrilysin, uterine); Degrades casein, gelatins of types I, III, IV, and V, and fibronectin. Activates procollagenase | 0.941 |
COL18A1 | PRSS1 | ENSP00000347665 | ENSP00000308720 | collagen, type XVIII, alpha 1 | protease, serine, 1 (trypsin 1) | 0.900 |
DEFA5 | PRSS1 | ENSP00000329890 | ENSP00000308720 | defensin, alpha 5, Paneth cell-specific; Has antimicrobial activity against Gram-negative and Gram-positive bacteria. Defensins are thought to kill microbes by permeabilizing their plasma membrane. All DEFA5 peptides exert antimicrobial activities, but their potency is affected by peptide processing | protease, serine, 1 (trypsin 1) | 0.576 |
F2R | F2RL1 | ENSP00000321326 | ENSP00000296677 | coagulation factor II (thrombin) receptor; High affinity receptor for activated thrombin coupled to G proteins that stimulate phosphoinositide hydrolysis. May play a role in platelets activation and in vascular development | coagulation factor II (thrombin) receptor-like 1; Receptor for trypsin and trypsin-like enzymes coupled to G proteins. Its function is mediated through the activation of several signaling pathways including phospholipase C (PLC), intracellular calcium, mitogen-activated protein kinase (MAPK), I- kappaB kinase/NF-kappaB and Rho. Can also be transactivated by cleaved F2R/PAR1. Involved in modulation of inflammatory responses and regulation of innate and adaptive immunity, and acts as a sensor for proteolytic enzymes generated during infection. Generally is promoting inflammation. Can sig [...] | 0.911 |
F2R | F2RL2 | ENSP00000321326 | ENSP00000296641 | coagulation factor II (thrombin) receptor; High affinity receptor for activated thrombin coupled to G proteins that stimulate phosphoinositide hydrolysis. May play a role in platelets activation and in vascular development | coagulation factor II (thrombin) receptor-like 2; Receptor for activated thrombin coupled to G proteins that stimulate phosphoinositide hydrolysis | 0.961 |
F2R | F2RL3 | ENSP00000321326 | ENSP00000248076 | coagulation factor II (thrombin) receptor; High affinity receptor for activated thrombin coupled to G proteins that stimulate phosphoinositide hydrolysis. May play a role in platelets activation and in vascular development | coagulation factor II (thrombin) receptor-like 3; Receptor for activated thrombin or trypsin coupled to G proteins that stimulate phosphoinositide hydrolysis. May play a role in platelets activation | 0.913 |
F2R | MMP1 | ENSP00000321326 | ENSP00000322788 | coagulation factor II (thrombin) receptor; High affinity receptor for activated thrombin coupled to G proteins that stimulate phosphoinositide hydrolysis. May play a role in platelets activation and in vascular development | matrix metallopeptidase 1 (interstitial collagenase); Cleaves collagens of types I, II, and III at one site in the helical domain. Also cleaves collagens of types VII and X. In case of HIV infection, interacts and cleaves the secreted viral Tat protein, leading to a decrease in neuronal Tat’s mediated neurotoxicity | 0.827 |
F2R | PRSS1 | ENSP00000321326 | ENSP00000308720 | coagulation factor II (thrombin) receptor; High affinity receptor for activated thrombin coupled to G proteins that stimulate phosphoinositide hydrolysis. May play a role in platelets activation and in vascular development | protease, serine, 1 (trypsin 1) | 0.810 |
F2R | UBC | ENSP00000321326 | ENSP00000344818 | coagulation factor II (thrombin) receptor; High affinity receptor for activated thrombin coupled to G proteins that stimulate phosphoinositide hydrolysis. May play a role in platelets activation and in vascular development | ubiquitin C | 0.882 |
F2RL1 | F2R | ENSP00000296677 | ENSP00000321326 | coagulation factor II (thrombin) receptor-like 1; Receptor for trypsin and trypsin-like enzymes coupled to G proteins. Its function is mediated through the activation of several signaling pathways including phospholipase C (PLC), intracellular calcium, mitogen-activated protein kinase (MAPK), I- kappaB kinase/NF-kappaB and Rho. Can also be transactivated by cleaved F2R/PAR1. Involved in modulation of inflammatory responses and regulation of innate and adaptive immunity, and acts as a sensor for proteolytic enzymes generated during infection. Generally is promoting inflammation. Can sig [...] | coagulation factor II (thrombin) receptor; High affinity receptor for activated thrombin coupled to G proteins that stimulate phosphoinositide hydrolysis. May play a role in platelets activation and in vascular development | 0.911 |
F2RL1 | F2RL2 | ENSP00000296677 | ENSP00000296641 | coagulation factor II (thrombin) receptor-like 1; Receptor for trypsin and trypsin-like enzymes coupled to G proteins. Its function is mediated through the activation of several signaling pathways including phospholipase C (PLC), intracellular calcium, mitogen-activated protein kinase (MAPK), I- kappaB kinase/NF-kappaB and Rho. Can also be transactivated by cleaved F2R/PAR1. Involved in modulation of inflammatory responses and regulation of innate and adaptive immunity, and acts as a sensor for proteolytic enzymes generated during infection. Generally is promoting inflammation. Can sig [...] | coagulation factor II (thrombin) receptor-like 2; Receptor for activated thrombin coupled to G proteins that stimulate phosphoinositide hydrolysis | 0.905 |
F2RL1 | F2RL3 | ENSP00000296677 | ENSP00000248076 | coagulation factor II (thrombin) receptor-like 1; Receptor for trypsin and trypsin-like enzymes coupled to G proteins. Its function is mediated through the activation of several signaling pathways including phospholipase C (PLC), intracellular calcium, mitogen-activated protein kinase (MAPK), I- kappaB kinase/NF-kappaB and Rho. Can also be transactivated by cleaved F2R/PAR1. Involved in modulation of inflammatory responses and regulation of innate and adaptive immunity, and acts as a sensor for proteolytic enzymes generated during infection. Generally is promoting inflammation. Can sig [...] | coagulation factor II (thrombin) receptor-like 3; Receptor for activated thrombin or trypsin coupled to G proteins that stimulate phosphoinositide hydrolysis. May play a role in platelets activation | 0.909 |
F2RL1 | PRSS1 | ENSP00000296677 | ENSP00000308720 | coagulation factor II (thrombin) receptor-like 1; Receptor for trypsin and trypsin-like enzymes coupled to G proteins. Its function is mediated through the activation of several signaling pathways including phospholipase C (PLC), intracellular calcium, mitogen-activated protein kinase (MAPK), I- kappaB kinase/NF-kappaB and Rho. Can also be transactivated by cleaved F2R/PAR1. Involved in modulation of inflammatory responses and regulation of innate and adaptive immunity, and acts as a sensor for proteolytic enzymes generated during infection. Generally is promoting inflammation. Can sig [...] | protease, serine, 1 (trypsin 1) | 0.840 |
F2RL1 | UBC | ENSP00000296677 | ENSP00000344818 | coagulation factor II (thrombin) receptor-like 1; Receptor for trypsin and trypsin-like enzymes coupled to G proteins. Its function is mediated through the activation of several signaling pathways including phospholipase C (PLC), intracellular calcium, mitogen-activated protein kinase (MAPK), I- kappaB kinase/NF-kappaB and Rho. Can also be transactivated by cleaved F2R/PAR1. Involved in modulation of inflammatory responses and regulation of innate and adaptive immunity, and acts as a sensor for proteolytic enzymes generated during infection. Generally is promoting inflammation. Can sig [...] | ubiquitin C | 0.771 |
F2RL2 | F2R | ENSP00000296641 | ENSP00000321326 | coagulation factor II (thrombin) receptor-like 2; Receptor for activated thrombin coupled to G proteins that stimulate phosphoinositide hydrolysis | coagulation factor II (thrombin) receptor; High affinity receptor for activated thrombin coupled to G proteins that stimulate phosphoinositide hydrolysis. May play a role in platelets activation and in vascular development | 0.961 |
F2RL2 | F2RL1 | ENSP00000296641 | ENSP00000296677 | coagulation factor II (thrombin) receptor-like 2; Receptor for activated thrombin coupled to G proteins that stimulate phosphoinositide hydrolysis | coagulation factor II (thrombin) receptor-like 1; Receptor for trypsin and trypsin-like enzymes coupled to G proteins. Its function is mediated through the activation of several signaling pathways including phospholipase C (PLC), intracellular calcium, mitogen-activated protein kinase (MAPK), I- kappaB kinase/NF-kappaB and Rho. Can also be transactivated by cleaved F2R/PAR1. Involved in modulation of inflammatory responses and regulation of innate and adaptive immunity, and acts as a sensor for proteolytic enzymes generated during infection. Generally is promoting inflammation. Can sig [...] | 0.905 |
F2RL2 | F2RL3 | ENSP00000296641 | ENSP00000248076 | coagulation factor II (thrombin) receptor-like 2; Receptor for activated thrombin coupled to G proteins that stimulate phosphoinositide hydrolysis | coagulation factor II (thrombin) receptor-like 3; Receptor for activated thrombin or trypsin coupled to G proteins that stimulate phosphoinositide hydrolysis. May play a role in platelets activation | 0.960 |
F2RL2 | PRSS1 | ENSP00000296641 | ENSP00000308720 | coagulation factor II (thrombin) receptor-like 2; Receptor for activated thrombin coupled to G proteins that stimulate phosphoinositide hydrolysis | protease, serine, 1 (trypsin 1) | 0.800 |
F2RL3 | F2R | ENSP00000248076 | ENSP00000321326 | coagulation factor II (thrombin) receptor-like 3; Receptor for activated thrombin or trypsin coupled to G proteins that stimulate phosphoinositide hydrolysis. May play a role in platelets activation | coagulation factor II (thrombin) receptor; High affinity receptor for activated thrombin coupled to G proteins that stimulate phosphoinositide hydrolysis. May play a role in platelets activation and in vascular development | 0.913 |