node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
GAL | GPR151 | ENSP00000265643 | ENSP00000308733 | galanin/GMAP prepropeptide; Contracts smooth muscle of the gastrointestinal and genitourinary tract, regulates growth hormone release, modulates insulin release, and may be involved in the control of adrenal secretion | G protein-coupled receptor 151; Orphan receptor | 0.743 |
GPR151 | GAL | ENSP00000308733 | ENSP00000265643 | G protein-coupled receptor 151; Orphan receptor | galanin/GMAP prepropeptide; Contracts smooth muscle of the gastrointestinal and genitourinary tract, regulates growth hormone release, modulates insulin release, and may be involved in the control of adrenal secretion | 0.743 |
GPR151 | PLCH2 | ENSP00000308733 | ENSP00000367747 | G protein-coupled receptor 151; Orphan receptor | phospholipase C, eta 2 | 0.498 |
PLCB1 | PLCB2 | ENSP00000338185 | ENSP00000260402 | phospholipase C, beta 1 (phosphoinositide-specific) | phospholipase C, beta 2; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes | 0.904 |
PLCB1 | PLCB3 | ENSP00000338185 | ENSP00000279230 | phospholipase C, beta 1 (phosphoinositide-specific) | phospholipase C, beta 3 (phosphatidylinositol-specific); The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes | 0.902 |
PLCB1 | PLCB4 | ENSP00000338185 | ENSP00000334105 | phospholipase C, beta 1 (phosphoinositide-specific) | phospholipase C, beta 4 | 0.905 |
PLCB1 | PLCD1 | ENSP00000338185 | ENSP00000430344 | phospholipase C, beta 1 (phosphoinositide-specific) | phospholipase C, delta 1; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. Essential for trophoblast and placental development | 0.914 |
PLCB1 | PLCD3 | ENSP00000338185 | ENSP00000313731 | phospholipase C, beta 1 (phosphoinositide-specific) | phospholipase C, delta 3; Hydrolyzes the phosphatidylinositol 4,5-bisphosphate (PIP2) to generate 2 second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). DAG mediates the activation of protein kinase C (PKC), while IP3 releases Ca(2+) from intracellular stores. Essential for trophoblast and placental development. May participate in cytokinesis by hydrolyzing PIP2 at the cleavage furrow | 0.913 |
PLCB1 | PLCD4 | ENSP00000338185 | ENSP00000388631 | phospholipase C, beta 1 (phosphoinositide-specific) | phospholipase C, delta 4; Hydrolyzes the phosphatidylinositol 4,5-bisphosphate (PIP2) to generate 2 second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). DAG mediates the activation of protein kinase C (PKC), while IP3 releases Ca(2+) from intracellular stores. Required for acrosome reaction in sperm during fertilization, probably by acting as an important enzyme for intracellular Ca(2+) mobilization in the zona pellucida- induced acrosome reaction. May play a role in cell growth. Modulates the liver regeneration in cooperation with nuclear PKC. Overex [...] | 0.910 |
PLCB1 | PLCE1 | ENSP00000338185 | ENSP00000260766 | phospholipase C, beta 1 (phosphoinositide-specific) | phospholipase C, epsilon 1 | 0.911 |
PLCB2 | PLCB1 | ENSP00000260402 | ENSP00000338185 | phospholipase C, beta 2; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes | phospholipase C, beta 1 (phosphoinositide-specific) | 0.904 |
PLCB2 | PLCB3 | ENSP00000260402 | ENSP00000279230 | phospholipase C, beta 2; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes | phospholipase C, beta 3 (phosphatidylinositol-specific); The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes | 0.905 |
PLCB2 | PLCB4 | ENSP00000260402 | ENSP00000334105 | phospholipase C, beta 2; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes | phospholipase C, beta 4 | 0.907 |
PLCB2 | PLCD1 | ENSP00000260402 | ENSP00000430344 | phospholipase C, beta 2; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes | phospholipase C, delta 1; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. Essential for trophoblast and placental development | 0.912 |
PLCB2 | PLCD3 | ENSP00000260402 | ENSP00000313731 | phospholipase C, beta 2; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes | phospholipase C, delta 3; Hydrolyzes the phosphatidylinositol 4,5-bisphosphate (PIP2) to generate 2 second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). DAG mediates the activation of protein kinase C (PKC), while IP3 releases Ca(2+) from intracellular stores. Essential for trophoblast and placental development. May participate in cytokinesis by hydrolyzing PIP2 at the cleavage furrow | 0.909 |
PLCB2 | PLCD4 | ENSP00000260402 | ENSP00000388631 | phospholipase C, beta 2; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes | phospholipase C, delta 4; Hydrolyzes the phosphatidylinositol 4,5-bisphosphate (PIP2) to generate 2 second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). DAG mediates the activation of protein kinase C (PKC), while IP3 releases Ca(2+) from intracellular stores. Required for acrosome reaction in sperm during fertilization, probably by acting as an important enzyme for intracellular Ca(2+) mobilization in the zona pellucida- induced acrosome reaction. May play a role in cell growth. Modulates the liver regeneration in cooperation with nuclear PKC. Overex [...] | 0.913 |
PLCB2 | PLCE1 | ENSP00000260402 | ENSP00000260766 | phospholipase C, beta 2; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes | phospholipase C, epsilon 1 | 0.913 |
PLCB3 | PLCB1 | ENSP00000279230 | ENSP00000338185 | phospholipase C, beta 3 (phosphatidylinositol-specific); The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes | phospholipase C, beta 1 (phosphoinositide-specific) | 0.902 |
PLCB3 | PLCB2 | ENSP00000279230 | ENSP00000260402 | phospholipase C, beta 3 (phosphatidylinositol-specific); The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes | phospholipase C, beta 2; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes | 0.905 |
PLCB3 | PLCB4 | ENSP00000279230 | ENSP00000334105 | phospholipase C, beta 3 (phosphatidylinositol-specific); The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes | phospholipase C, beta 4 | 0.908 |