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MRPL34 MRPL34 MRPL43 MRPL43 MRPL17 MRPL17 MRPL33 MRPL33 MRPL40 MRPL40 MRPL49 MRPL49 MRPL46 MRPL46 MRPL32 MRPL32 MRPL27 MRPL27 FUBP1 FUBP1 LGALS1 LGALS1 HIST1H2AB HIST1H2AB STRAP STRAP PSMG1 PSMG1 UBC UBC NCKAP1 NCKAP1 FBXL5 FBXL5 ACO1 ACO1 DCPS DCPS NCKAP1L NCKAP1L AKT1 AKT1 IDH3A IDH3A ACLY ACLY CTPS1 CTPS1 IDH3B IDH3B FXN FXN
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small protein node
small nodes:
protein of unknown 3D structure
large protein node
large nodes:
some 3D structure is known or predicted
Node Color
colored protein node
colored nodes:
query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
database edge
from curated databases
experiment edge
experimentally determined
Predicted Interactions
neighborhood edge
gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
Others
textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
Your Input:
LGALS1lectin, galactoside-binding, soluble, 1; May regulate apoptosis, cell proliferation and cell differentiation. Binds beta-galactoside and a wide array of complex carbohydrates. Inhibits CD45 protein phosphatase activity and therefore the dephosphorylation of Lyn kinase (135 aa)
MRPL32mitochondrial ribosomal protein L32 (188 aa)
MRPL27mitochondrial ribosomal protein L27 (148 aa)
MRPL34mitochondrial ribosomal protein L34 (92 aa)
ACLYATP citrate lyase; ATP citrate-lyase is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues. Has a central role in de novo lipid synthesis. In nervous tissue it may be involved in the biosynthesis of acetylcholine (1101 aa)
HIST1H2ABhistone cluster 1, H2ab (130 aa)
DCPSdecapping enzyme, scavenger; Decapping scavenger enzyme that catalyzes the cleavage of a residual cap structure following the degradation of mRNAs by the 3’->5’ exosome-mediated mRNA decay pathway. Hydrolyzes cap analog structures like 7-methylguanosine nucleoside triphosphate (m7GpppG) with up to 10 nucleotide substrates (small capped oligoribonucleotides) and specifically releases 5’-phosphorylated RNA fragments and 7-methylguanosine monophosphate (m7GMP). Cleaves cap analog structures like tri-methyl guanosine nucleoside triphosphate (m3(2,2,7)GpppG) with very poor efficiency. Does [...] (337 aa)
AKT1v-akt murine thymoma viral oncogene homolog 1; AKT1 is one of 3 closely related serine/threonine- protein kinases (AKT1, AKT2 and AKT3) called the AKT kinase, and which regulate many processes including metabolism, proliferation, cell survival, growth and angiogenesis. This is mediated through serine and/or threonine phosphorylation of a range of downstream substrates. Over 100 substrate candidates have been reported so far, but for most of them, no isoform specificity has been reported. AKT is responsible of the regulation of glucose uptake by mediating insulin-induced translocation o [...] (480 aa)
MRPL49mitochondrial ribosomal protein L49 (166 aa)
MRPL17mitochondrial ribosomal protein L17 (175 aa)
NCKAP1LNCK-associated protein 1-like (1127 aa)
MRPL33mitochondrial ribosomal protein L33 (65 aa)
IDH3Aisocitrate dehydrogenase 3 (NAD+) alpha (366 aa)
ACO1aconitase 1, soluble; Iron sensor. Binds a 4Fe-4S cluster and functions as aconitase when cellular iron levels are high. Functions as mRNA binding protein that regulates uptake, sequestration and utilization of iron when cellular iron levels are low. Binds to iron-responsive elements (IRES) in target mRNA species when iron levels are low. Binding of a 4Fe-4S cluster precludes RNA binding (889 aa)
MRPL46mitochondrial ribosomal protein L46 (279 aa)
PSMG1proteasome (prosome, macropain) assembly chaperone 1; Chaperone protein which promotes assembly of the 20S proteasome as part of a heterodimer with PSMG2. The PSMG1-PSMG2 heterodimer binds to the PSMA5 and PSMA7 proteasome subunits, promotes assembly of the proteasome alpha subunits into the heteroheptameric alpha ring and prevents alpha ring dimerization (288 aa)
MRPL40mitochondrial ribosomal protein L40 (206 aa)
MRPL43mitochondrial ribosomal protein L43 (235 aa)
UBCubiquitin C (685 aa)
FBXL5F-box and leucine-rich repeat protein 5 (691 aa)
NCKAP1NCK-associated protein 1; Part of the WAVE complex that regulates lamellipodia formation. The WAVE complex regulates actin filament reorganization via its interaction with the Arp2/3 complex. Actin remodeling activity is regulated by RAC1 (1134 aa)
FUBP1far upstream element (FUSE) binding protein 1; Regulates MYC expression by binding to a single-stranded far-upstream element (FUSE) upstream of the MYC promoter. May act both as activator and repressor of transcription (644 aa)
CTPS1CTP synthase 1; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (591 aa)
FXNfrataxin; Promotes the biosynthesis of heme and assembly and repair of iron-sulfur clusters by delivering Fe(2+) to proteins involved in these pathways. May play a role in the protection against iron-catalyzed oxidative stress through its ability to catalyze the oxidation of Fe(2+) to Fe(3+); the oligomeric form but not the monomeric form has in vitro ferroxidase activity. May be able to store large amounts of iron in the form of a ferrihydrite mineral by oligomerization; however, the physiological relevance is unsure as reports are conflicting and the function has only been shown usin [...] (210 aa)
IDH3Bisocitrate dehydrogenase 3 (NAD+) beta (385 aa)
STRAPserine/threonine kinase receptor associated protein; The SMN complex plays an essential role in spliceosomal snRNP assembly in the cytoplasm and is required for pre-mRNA splicing in the nucleus. STRAP may play a role in the cellular distribution of the SMN complex. Negatively regulates TGF-beta signaling but positively regulates the PDPK1 kinase activity by enhancing its autophosphorylation and by significantly reducing the association of PDPK1 with 14-3-3 protein (350 aa)
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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