node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
C19orf70 | LAMTOR3 | ENSP00000309561 | ENSP00000424183 | chromosome 19 open reading frame 70 | late endosomal/lysosomal adaptor, MAPK and MTOR activator 3; As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V-ATPase, the Ragulator functions as a guanine nucleotide exchange factor activating the small GTPases Rag. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated. Adapter protein that enhances th [...] | 0.644 |
C19orf70 | MRPL24 | ENSP00000309561 | ENSP00000354525 | chromosome 19 open reading frame 70 | mitochondrial ribosomal protein L24 | 0.644 |
C19orf70 | SLC25A3 | ENSP00000309561 | ENSP00000228318 | chromosome 19 open reading frame 70 | solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 3; Transport of phosphate groups from the cytosol to the mitochondrial matrix. Phosphate is cotransported with H(+). May play a role regulation of the mitochondrial permeability transition pore (mPTP) | 0.644 |
C19orf70 | UBC | ENSP00000309561 | ENSP00000344818 | chromosome 19 open reading frame 70 | ubiquitin C | 0.483 |
CLN3 | UBC | ENSP00000353073 | ENSP00000344818 | ceroid-lipofuscinosis, neuronal 3 | ubiquitin C | 0.924 |
LAMTOR3 | C19orf70 | ENSP00000424183 | ENSP00000309561 | late endosomal/lysosomal adaptor, MAPK and MTOR activator 3; As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V-ATPase, the Ragulator functions as a guanine nucleotide exchange factor activating the small GTPases Rag. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated. Adapter protein that enhances th [...] | chromosome 19 open reading frame 70 | 0.644 |
LAMTOR3 | UBC | ENSP00000424183 | ENSP00000344818 | late endosomal/lysosomal adaptor, MAPK and MTOR activator 3; As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V-ATPase, the Ragulator functions as a guanine nucleotide exchange factor activating the small GTPases Rag. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated. Adapter protein that enhances th [...] | ubiquitin C | 0.483 |
MRPL24 | C19orf70 | ENSP00000354525 | ENSP00000309561 | mitochondrial ribosomal protein L24 | chromosome 19 open reading frame 70 | 0.644 |
MRPL24 | UBC | ENSP00000354525 | ENSP00000344818 | mitochondrial ribosomal protein L24 | ubiquitin C | 0.553 |
PELO | UBC | ENSP00000274311 | ENSP00000344818 | pelota homolog (Drosophila); Required for normal chromosome segregation during cell division and genomic stability (By similarity). May function in recognizing stalled ribosomes and triggering endonucleolytic cleavage of the mRNA, a mechanism to release non-functional ribosomes and degrade damaged mRNAs. May have ribonuclease activity (Potential) | ubiquitin C | 0.947 |
SLC25A3 | C19orf70 | ENSP00000228318 | ENSP00000309561 | solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 3; Transport of phosphate groups from the cytosol to the mitochondrial matrix. Phosphate is cotransported with H(+). May play a role regulation of the mitochondrial permeability transition pore (mPTP) | chromosome 19 open reading frame 70 | 0.644 |
SLC25A3 | UBC | ENSP00000228318 | ENSP00000344818 | solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 3; Transport of phosphate groups from the cytosol to the mitochondrial matrix. Phosphate is cotransported with H(+). May play a role regulation of the mitochondrial permeability transition pore (mPTP) | ubiquitin C | 0.976 |
TSC22D1 | UBC | ENSP00000397435 | ENSP00000344818 | TSC22 domain family, member 1; Transcriptional repressor. Acts on the C-type natriuretic peptide (CNP) promoter | ubiquitin C | 0.812 |
UBC | C19orf70 | ENSP00000344818 | ENSP00000309561 | ubiquitin C | chromosome 19 open reading frame 70 | 0.483 |
UBC | CLN3 | ENSP00000344818 | ENSP00000353073 | ubiquitin C | ceroid-lipofuscinosis, neuronal 3 | 0.924 |
UBC | LAMTOR3 | ENSP00000344818 | ENSP00000424183 | ubiquitin C | late endosomal/lysosomal adaptor, MAPK and MTOR activator 3; As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V-ATPase, the Ragulator functions as a guanine nucleotide exchange factor activating the small GTPases Rag. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated. Adapter protein that enhances th [...] | 0.483 |
UBC | MRPL24 | ENSP00000344818 | ENSP00000354525 | ubiquitin C | mitochondrial ribosomal protein L24 | 0.553 |
UBC | PELO | ENSP00000344818 | ENSP00000274311 | ubiquitin C | pelota homolog (Drosophila); Required for normal chromosome segregation during cell division and genomic stability (By similarity). May function in recognizing stalled ribosomes and triggering endonucleolytic cleavage of the mRNA, a mechanism to release non-functional ribosomes and degrade damaged mRNAs. May have ribonuclease activity (Potential) | 0.947 |
UBC | SLC25A3 | ENSP00000344818 | ENSP00000228318 | ubiquitin C | solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 3; Transport of phosphate groups from the cytosol to the mitochondrial matrix. Phosphate is cotransported with H(+). May play a role regulation of the mitochondrial permeability transition pore (mPTP) | 0.976 |
UBC | TSC22D1 | ENSP00000344818 | ENSP00000397435 | ubiquitin C | TSC22 domain family, member 1; Transcriptional repressor. Acts on the C-type natriuretic peptide (CNP) promoter | 0.812 |