node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
C5orf24 | EFEMP2 | ENSP00000337044 | ENSP00000309953 | chromosome 5 open reading frame 24 | EGF containing fibulin-like extracellular matrix protein 2 | 0.483 |
EFEMP2 | C5orf24 | ENSP00000309953 | ENSP00000337044 | EGF containing fibulin-like extracellular matrix protein 2 | chromosome 5 open reading frame 24 | 0.483 |
EFEMP2 | FBLN5 | ENSP00000309953 | ENSP00000345008 | EGF containing fibulin-like extracellular matrix protein 2 | fibulin 5; Promotes adhesion of endothelial cells through interaction of integrins and the RGD motif. Could be a vascular ligand for integrin receptors and may play a role in vascular development and remodeling | 0.957 |
EFEMP2 | FBN1 | ENSP00000309953 | ENSP00000325527 | EGF containing fibulin-like extracellular matrix protein 2 | fibrillin 1; Fibrillins are structural components of 10-12 nm extracellular calcium-binding microfibrils, which occur either in association with elastin or in elastin-free bundles. Fibrillin-1- containing microfibrils provide long-term force bearing structural support. Regulates osteoblast maturation by controlling TGF-beta bioavailability and calibrating TGF-beta and BMP levels, respectively | 0.641 |
EFEMP2 | LOX | ENSP00000309953 | ENSP00000231004 | EGF containing fibulin-like extracellular matrix protein 2 | lysyl oxidase; Responsible for the post-translational oxidative deamination of peptidyl lysine residues in precursors to fibrous collagen and elastin. In addition to cross-linking of extracellular matrix proteins, may have a direct role in tumor suppression | 0.989 |
EFEMP2 | MFAP1 | ENSP00000309953 | ENSP00000267812 | EGF containing fibulin-like extracellular matrix protein 2 | microfibrillar-associated protein 1; Component of the elastin-associated microfibrils | 0.920 |
EFEMP2 | MFAP2 | ENSP00000309953 | ENSP00000364685 | EGF containing fibulin-like extracellular matrix protein 2 | microfibrillar-associated protein 2; Component of the elastin-associated microfibrils | 0.936 |
EFEMP2 | MFAP3 | ENSP00000309953 | ENSP00000322956 | EGF containing fibulin-like extracellular matrix protein 2 | microfibrillar-associated protein 3; Component of the elastin-associated microfibrils | 0.900 |
EFEMP2 | MFAP4 | ENSP00000309953 | ENSP00000378957 | EGF containing fibulin-like extracellular matrix protein 2 | microfibrillar-associated protein 4; Could be involved in calcium-dependent cell adhesion or intercellular interactions | 0.905 |
EFEMP2 | MFAP5 | ENSP00000309953 | ENSP00000352455 | EGF containing fibulin-like extracellular matrix protein 2 | microfibrillar associated protein 5; Component of the elastin-associated microfibrils | 0.931 |
EFEMP2 | PLSCR4 | ENSP00000309953 | ENSP00000347038 | EGF containing fibulin-like extracellular matrix protein 2 | phospholipid scramblase 4; May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane. May play a central role in the initiation of fibrin clot formation, in the activation of mast cells and in the recognition of apoptotic and injured cells by the reticuloendothelial system | 0.438 |
EFEMP2 | SGTB | ENSP00000309953 | ENSP00000370395 | EGF containing fibulin-like extracellular matrix protein 2 | small glutamine-rich tetratricopeptide repeat (TPR)-containing, beta; Co-chaperone that binds directly to HSC70 and HSP70 and regulates their ATPase activity (By similarity) | 0.600 |
EFEMP2 | TP53 | ENSP00000309953 | ENSP00000269305 | EGF containing fibulin-like extracellular matrix protein 2 | tumor protein p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression (By similarity) | 0.608 |
ELN | FBN1 | ENSP00000252034 | ENSP00000325527 | elastin | fibrillin 1; Fibrillins are structural components of 10-12 nm extracellular calcium-binding microfibrils, which occur either in association with elastin or in elastin-free bundles. Fibrillin-1- containing microfibrils provide long-term force bearing structural support. Regulates osteoblast maturation by controlling TGF-beta bioavailability and calibrating TGF-beta and BMP levels, respectively | 0.576 |
ELN | LOX | ENSP00000252034 | ENSP00000231004 | elastin | lysyl oxidase; Responsible for the post-translational oxidative deamination of peptidyl lysine residues in precursors to fibrous collagen and elastin. In addition to cross-linking of extracellular matrix proteins, may have a direct role in tumor suppression | 0.808 |
ELN | MFAP2 | ENSP00000252034 | ENSP00000364685 | elastin | microfibrillar-associated protein 2; Component of the elastin-associated microfibrils | 0.576 |
FBLN5 | EFEMP2 | ENSP00000345008 | ENSP00000309953 | fibulin 5; Promotes adhesion of endothelial cells through interaction of integrins and the RGD motif. Could be a vascular ligand for integrin receptors and may play a role in vascular development and remodeling | EGF containing fibulin-like extracellular matrix protein 2 | 0.957 |
FBLN5 | FBN1 | ENSP00000345008 | ENSP00000325527 | fibulin 5; Promotes adhesion of endothelial cells through interaction of integrins and the RGD motif. Could be a vascular ligand for integrin receptors and may play a role in vascular development and remodeling | fibrillin 1; Fibrillins are structural components of 10-12 nm extracellular calcium-binding microfibrils, which occur either in association with elastin or in elastin-free bundles. Fibrillin-1- containing microfibrils provide long-term force bearing structural support. Regulates osteoblast maturation by controlling TGF-beta bioavailability and calibrating TGF-beta and BMP levels, respectively | 0.966 |
FBLN5 | LOX | ENSP00000345008 | ENSP00000231004 | fibulin 5; Promotes adhesion of endothelial cells through interaction of integrins and the RGD motif. Could be a vascular ligand for integrin receptors and may play a role in vascular development and remodeling | lysyl oxidase; Responsible for the post-translational oxidative deamination of peptidyl lysine residues in precursors to fibrous collagen and elastin. In addition to cross-linking of extracellular matrix proteins, may have a direct role in tumor suppression | 0.993 |
FBLN5 | MFAP1 | ENSP00000345008 | ENSP00000267812 | fibulin 5; Promotes adhesion of endothelial cells through interaction of integrins and the RGD motif. Could be a vascular ligand for integrin receptors and may play a role in vascular development and remodeling | microfibrillar-associated protein 1; Component of the elastin-associated microfibrils | 0.910 |