node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ACACA | ACACB | ENSP00000344789 | ENSP00000341044 | acetyl-CoA carboxylase alpha | acetyl-CoA carboxylase beta; ACC-beta may be involved in the provision of malonyl-CoA or in the regulation of fatty acid oxidation, rather than fatty acid biosynthesis. Carries out three functions- biotin carboxyl carrier protein, biotin carboxylase and carboxyltransferase | 0.999 |
ACACA | HLCS | ENSP00000344789 | ENSP00000338387 | acetyl-CoA carboxylase alpha | holocarboxylase synthetase (biotin-(proprionyl-CoA-carboxylase (ATP-hydrolysing)) ligase); Post-translational modification of specific protein by attachment of biotin. Acts on various carboxylases such as acetyl- CoA-carboxylase, pyruvate carboxylase, propionyl CoA carboxylase, and 3-methylcrotonyl CoA carboxylase | 0.995 |
ACACA | MCCC1 | ENSP00000344789 | ENSP00000265594 | acetyl-CoA carboxylase alpha | methylcrotonoyl-CoA carboxylase 1 (alpha) | 0.841 |
ACACA | PC | ENSP00000344789 | ENSP00000377527 | acetyl-CoA carboxylase alpha | pyruvate carboxylase; Pyruvate carboxylase catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second. Catalyzes in a tissue specific manner, the initial reactions of glucose (liver, kidney) and lipid (adipose tissue, liver, brain) synthesis from pyruvate | 0.638 |
ACACA | PCCA | ENSP00000344789 | ENSP00000365462 | acetyl-CoA carboxylase alpha | propionyl CoA carboxylase, alpha polypeptide | 0.839 |
ACACA | PCCB | ENSP00000344789 | ENSP00000419027 | acetyl-CoA carboxylase alpha | propionyl CoA carboxylase, beta polypeptide | 0.758 |
ACACA | PIKFYVE | ENSP00000344789 | ENSP00000264380 | acetyl-CoA carboxylase alpha | phosphoinositide kinase, FYVE finger containing; The PI(3,5)P2 regulatory complex regulates both the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). Catalyzes the phosphorylation of phosphatidylinositol 3-phosphate on the fifth hydroxyl of the myo- inositol ring, to form phosphatidylinositol 3,5-bisphosphate. Required for endocytic-vacuolar pathway and nuclear migration. Plays a role in the biogenesis of endosome carrier vesicles (ECV)/ multivesicular bodies (MVB) transport intermediates from early endosomes | 0.876 |
ACACA | SLC5A6 | ENSP00000344789 | ENSP00000310208 | acetyl-CoA carboxylase alpha | solute carrier family 5 (sodium-dependent vitamin transporter), member 6; Transports pantothenate, biotin and lipoate in the presence of sodium | 0.951 |
ACACA | UBC | ENSP00000344789 | ENSP00000344818 | acetyl-CoA carboxylase alpha | ubiquitin C | 0.922 |
ACACB | ACACA | ENSP00000341044 | ENSP00000344789 | acetyl-CoA carboxylase beta; ACC-beta may be involved in the provision of malonyl-CoA or in the regulation of fatty acid oxidation, rather than fatty acid biosynthesis. Carries out three functions- biotin carboxyl carrier protein, biotin carboxylase and carboxyltransferase | acetyl-CoA carboxylase alpha | 0.999 |
ACACB | HLCS | ENSP00000341044 | ENSP00000338387 | acetyl-CoA carboxylase beta; ACC-beta may be involved in the provision of malonyl-CoA or in the regulation of fatty acid oxidation, rather than fatty acid biosynthesis. Carries out three functions- biotin carboxyl carrier protein, biotin carboxylase and carboxyltransferase | holocarboxylase synthetase (biotin-(proprionyl-CoA-carboxylase (ATP-hydrolysing)) ligase); Post-translational modification of specific protein by attachment of biotin. Acts on various carboxylases such as acetyl- CoA-carboxylase, pyruvate carboxylase, propionyl CoA carboxylase, and 3-methylcrotonyl CoA carboxylase | 0.997 |
ACACB | MCCC1 | ENSP00000341044 | ENSP00000265594 | acetyl-CoA carboxylase beta; ACC-beta may be involved in the provision of malonyl-CoA or in the regulation of fatty acid oxidation, rather than fatty acid biosynthesis. Carries out three functions- biotin carboxyl carrier protein, biotin carboxylase and carboxyltransferase | methylcrotonoyl-CoA carboxylase 1 (alpha) | 0.824 |
ACACB | PC | ENSP00000341044 | ENSP00000377527 | acetyl-CoA carboxylase beta; ACC-beta may be involved in the provision of malonyl-CoA or in the regulation of fatty acid oxidation, rather than fatty acid biosynthesis. Carries out three functions- biotin carboxyl carrier protein, biotin carboxylase and carboxyltransferase | pyruvate carboxylase; Pyruvate carboxylase catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second. Catalyzes in a tissue specific manner, the initial reactions of glucose (liver, kidney) and lipid (adipose tissue, liver, brain) synthesis from pyruvate | 0.634 |
ACACB | PCCA | ENSP00000341044 | ENSP00000365462 | acetyl-CoA carboxylase beta; ACC-beta may be involved in the provision of malonyl-CoA or in the regulation of fatty acid oxidation, rather than fatty acid biosynthesis. Carries out three functions- biotin carboxyl carrier protein, biotin carboxylase and carboxyltransferase | propionyl CoA carboxylase, alpha polypeptide | 0.826 |
ACACB | PCCB | ENSP00000341044 | ENSP00000419027 | acetyl-CoA carboxylase beta; ACC-beta may be involved in the provision of malonyl-CoA or in the regulation of fatty acid oxidation, rather than fatty acid biosynthesis. Carries out three functions- biotin carboxyl carrier protein, biotin carboxylase and carboxyltransferase | propionyl CoA carboxylase, beta polypeptide | 0.768 |
ACACB | PIKFYVE | ENSP00000341044 | ENSP00000264380 | acetyl-CoA carboxylase beta; ACC-beta may be involved in the provision of malonyl-CoA or in the regulation of fatty acid oxidation, rather than fatty acid biosynthesis. Carries out three functions- biotin carboxyl carrier protein, biotin carboxylase and carboxyltransferase | phosphoinositide kinase, FYVE finger containing; The PI(3,5)P2 regulatory complex regulates both the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). Catalyzes the phosphorylation of phosphatidylinositol 3-phosphate on the fifth hydroxyl of the myo- inositol ring, to form phosphatidylinositol 3,5-bisphosphate. Required for endocytic-vacuolar pathway and nuclear migration. Plays a role in the biogenesis of endosome carrier vesicles (ECV)/ multivesicular bodies (MVB) transport intermediates from early endosomes | 0.876 |
ACACB | SLC5A6 | ENSP00000341044 | ENSP00000310208 | acetyl-CoA carboxylase beta; ACC-beta may be involved in the provision of malonyl-CoA or in the regulation of fatty acid oxidation, rather than fatty acid biosynthesis. Carries out three functions- biotin carboxyl carrier protein, biotin carboxylase and carboxyltransferase | solute carrier family 5 (sodium-dependent vitamin transporter), member 6; Transports pantothenate, biotin and lipoate in the presence of sodium | 0.955 |
ACACB | UBC | ENSP00000341044 | ENSP00000344818 | acetyl-CoA carboxylase beta; ACC-beta may be involved in the provision of malonyl-CoA or in the regulation of fatty acid oxidation, rather than fatty acid biosynthesis. Carries out three functions- biotin carboxyl carrier protein, biotin carboxylase and carboxyltransferase | ubiquitin C | 0.851 |
HLCS | ACACA | ENSP00000338387 | ENSP00000344789 | holocarboxylase synthetase (biotin-(proprionyl-CoA-carboxylase (ATP-hydrolysing)) ligase); Post-translational modification of specific protein by attachment of biotin. Acts on various carboxylases such as acetyl- CoA-carboxylase, pyruvate carboxylase, propionyl CoA carboxylase, and 3-methylcrotonyl CoA carboxylase | acetyl-CoA carboxylase alpha | 0.995 |
HLCS | ACACB | ENSP00000338387 | ENSP00000341044 | holocarboxylase synthetase (biotin-(proprionyl-CoA-carboxylase (ATP-hydrolysing)) ligase); Post-translational modification of specific protein by attachment of biotin. Acts on various carboxylases such as acetyl- CoA-carboxylase, pyruvate carboxylase, propionyl CoA carboxylase, and 3-methylcrotonyl CoA carboxylase | acetyl-CoA carboxylase beta; ACC-beta may be involved in the provision of malonyl-CoA or in the regulation of fatty acid oxidation, rather than fatty acid biosynthesis. Carries out three functions- biotin carboxyl carrier protein, biotin carboxylase and carboxyltransferase | 0.997 |