9 items (Homo sapiens) - STRING network view

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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protein of unknown 3D structure

large nodes:
some 3D structure is known or predicted

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

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textmining

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Your Input:
	ULBP1	UL16 binding protein 1; Ligand for the NKG2D receptor, together with at least ULBP2 and ULBP3. ULBPs activate multiple signaling pathways in primary NK cells, resulting in the production of cytokines and chemokines. Binding of ULBPs ligands to NKG2D induces calcium mobilization and activation of the JAK2, STAT5, ERK and PI3K kinase/Akt signal transduction pathway. In CMV infected cells, interacts with soluble CMV glycoprotein UL16. The interaction with UL16 blocked the interaction with the NKG2D receptor, providing a mechanism by which CMV infected cells might escape the immune system. [...] (244 aa)
	MICB	MHC class I polypeptide-related sequence B (383 aa)
	TYROBP	TYRO protein tyrosine kinase binding protein; Non-covalently associates with activating receptors of the CD300 family. Cross-linking of CD300-TYROBP complexes results in cellular activation. Involved for instance in neutrophil activation mediated by integrin (113 aa)
	KLRC4	killer cell lectin-like receptor subfamily C, member 4; May play a role as a receptor for the recognition of MHC class I HLA-E molecules by NK cells (158 aa)
	KLRD1	killer cell lectin-like receptor subfamily D, member 1; Plays a role as a receptor for the recognition of MHC class I HLA-E molecules by NK cells and some cytotoxic T-cells (179 aa)
	KLRC1	killer cell lectin-like receptor subfamily C, member 1; Plays a role as a receptor for the recognition of MHC class I HLA-E molecules by NK cells and some cytotoxic T-cells (233 aa)
	RAE1	RAE1 RNA export 1 homolog (S. pombe); Binds mRNA. May function in nucleocytoplasmic transport and in directly or indirectly attaching cytoplasmic mRNPs to the cytoskeleton (368 aa)
	KLRC2	killer cell lectin-like receptor subfamily C, member 2; Plays a role as a receptor for the recognition of MHC class I HLA-E molecules by NK cells and some cytotoxic T-cells (231 aa)
	B2M	beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system (By similarity) (119 aa)

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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a tab-delimited file describing the names, domains and annotated functions of the network proteins

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
B2M	KLRC1	ENSP00000452780	ENSP00000352064	beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system (By similarity)	killer cell lectin-like receptor subfamily C, member 1; Plays a role as a receptor for the recognition of MHC class I HLA-E molecules by NK cells and some cytotoxic T-cells	0.947
B2M	KLRC2	ENSP00000452780	ENSP00000371327	beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system (By similarity)	killer cell lectin-like receptor subfamily C, member 2; Plays a role as a receptor for the recognition of MHC class I HLA-E molecules by NK cells and some cytotoxic T-cells	0.954
B2M	KLRC4	ENSP00000452780	ENSP00000310216	beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system (By similarity)	killer cell lectin-like receptor subfamily C, member 4; May play a role as a receptor for the recognition of MHC class I HLA-E molecules by NK cells	0.923
B2M	KLRD1	ENSP00000452780	ENSP00000338130	beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system (By similarity)	killer cell lectin-like receptor subfamily D, member 1; Plays a role as a receptor for the recognition of MHC class I HLA-E molecules by NK cells and some cytotoxic T-cells	0.943
B2M	TYROBP	ENSP00000452780	ENSP00000262629	beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system (By similarity)	TYRO protein tyrosine kinase binding protein; Non-covalently associates with activating receptors of the CD300 family. Cross-linking of CD300-TYROBP complexes results in cellular activation. Involved for instance in neutrophil activation mediated by integrin	0.916
B2M	ULBP1	ENSP00000452780	ENSP00000229708	beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system (By similarity)	UL16 binding protein 1; Ligand for the NKG2D receptor, together with at least ULBP2 and ULBP3. ULBPs activate multiple signaling pathways in primary NK cells, resulting in the production of cytokines and chemokines. Binding of ULBPs ligands to NKG2D induces calcium mobilization and activation of the JAK2, STAT5, ERK and PI3K kinase/Akt signal transduction pathway. In CMV infected cells, interacts with soluble CMV glycoprotein UL16. The interaction with UL16 blocked the interaction with the NKG2D receptor, providing a mechanism by which CMV infected cells might escape the immune system. [...]	0.481
KLRC1	B2M	ENSP00000352064	ENSP00000452780	killer cell lectin-like receptor subfamily C, member 1; Plays a role as a receptor for the recognition of MHC class I HLA-E molecules by NK cells and some cytotoxic T-cells	beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system (By similarity)	0.947
KLRC1	KLRC2	ENSP00000352064	ENSP00000371327	killer cell lectin-like receptor subfamily C, member 1; Plays a role as a receptor for the recognition of MHC class I HLA-E molecules by NK cells and some cytotoxic T-cells	killer cell lectin-like receptor subfamily C, member 2; Plays a role as a receptor for the recognition of MHC class I HLA-E molecules by NK cells and some cytotoxic T-cells	0.904
KLRC1	KLRC4	ENSP00000352064	ENSP00000310216	killer cell lectin-like receptor subfamily C, member 1; Plays a role as a receptor for the recognition of MHC class I HLA-E molecules by NK cells and some cytotoxic T-cells	killer cell lectin-like receptor subfamily C, member 4; May play a role as a receptor for the recognition of MHC class I HLA-E molecules by NK cells	0.902
KLRC1	KLRD1	ENSP00000352064	ENSP00000338130	killer cell lectin-like receptor subfamily C, member 1; Plays a role as a receptor for the recognition of MHC class I HLA-E molecules by NK cells and some cytotoxic T-cells	killer cell lectin-like receptor subfamily D, member 1; Plays a role as a receptor for the recognition of MHC class I HLA-E molecules by NK cells and some cytotoxic T-cells	0.999
KLRC1	RAE1	ENSP00000352064	ENSP00000360286	killer cell lectin-like receptor subfamily C, member 1; Plays a role as a receptor for the recognition of MHC class I HLA-E molecules by NK cells and some cytotoxic T-cells	RAE1 RNA export 1 homolog (S. pombe); Binds mRNA. May function in nucleocytoplasmic transport and in directly or indirectly attaching cytoplasmic mRNPs to the cytoskeleton	0.509
KLRC1	TYROBP	ENSP00000352064	ENSP00000262629	killer cell lectin-like receptor subfamily C, member 1; Plays a role as a receptor for the recognition of MHC class I HLA-E molecules by NK cells and some cytotoxic T-cells	TYRO protein tyrosine kinase binding protein; Non-covalently associates with activating receptors of the CD300 family. Cross-linking of CD300-TYROBP complexes results in cellular activation. Involved for instance in neutrophil activation mediated by integrin	0.702
KLRC2	B2M	ENSP00000371327	ENSP00000452780	killer cell lectin-like receptor subfamily C, member 2; Plays a role as a receptor for the recognition of MHC class I HLA-E molecules by NK cells and some cytotoxic T-cells	beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system (By similarity)	0.954
KLRC2	KLRC1	ENSP00000371327	ENSP00000352064	killer cell lectin-like receptor subfamily C, member 2; Plays a role as a receptor for the recognition of MHC class I HLA-E molecules by NK cells and some cytotoxic T-cells	killer cell lectin-like receptor subfamily C, member 1; Plays a role as a receptor for the recognition of MHC class I HLA-E molecules by NK cells and some cytotoxic T-cells	0.904
KLRC2	KLRC4	ENSP00000371327	ENSP00000310216	killer cell lectin-like receptor subfamily C, member 2; Plays a role as a receptor for the recognition of MHC class I HLA-E molecules by NK cells and some cytotoxic T-cells	killer cell lectin-like receptor subfamily C, member 4; May play a role as a receptor for the recognition of MHC class I HLA-E molecules by NK cells	0.901
KLRC2	KLRD1	ENSP00000371327	ENSP00000338130	killer cell lectin-like receptor subfamily C, member 2; Plays a role as a receptor for the recognition of MHC class I HLA-E molecules by NK cells and some cytotoxic T-cells	killer cell lectin-like receptor subfamily D, member 1; Plays a role as a receptor for the recognition of MHC class I HLA-E molecules by NK cells and some cytotoxic T-cells	0.984
KLRC2	TYROBP	ENSP00000371327	ENSP00000262629	killer cell lectin-like receptor subfamily C, member 2; Plays a role as a receptor for the recognition of MHC class I HLA-E molecules by NK cells and some cytotoxic T-cells	TYRO protein tyrosine kinase binding protein; Non-covalently associates with activating receptors of the CD300 family. Cross-linking of CD300-TYROBP complexes results in cellular activation. Involved for instance in neutrophil activation mediated by integrin	0.977
KLRC4	B2M	ENSP00000310216	ENSP00000452780	killer cell lectin-like receptor subfamily C, member 4; May play a role as a receptor for the recognition of MHC class I HLA-E molecules by NK cells	beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system (By similarity)	0.923
KLRC4	KLRC1	ENSP00000310216	ENSP00000352064	killer cell lectin-like receptor subfamily C, member 4; May play a role as a receptor for the recognition of MHC class I HLA-E molecules by NK cells	killer cell lectin-like receptor subfamily C, member 1; Plays a role as a receptor for the recognition of MHC class I HLA-E molecules by NK cells and some cytotoxic T-cells	0.902
KLRC4	KLRC2	ENSP00000310216	ENSP00000371327	killer cell lectin-like receptor subfamily C, member 4; May play a role as a receptor for the recognition of MHC class I HLA-E molecules by NK cells	killer cell lectin-like receptor subfamily C, member 2; Plays a role as a receptor for the recognition of MHC class I HLA-E molecules by NK cells and some cytotoxic T-cells	0.901

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