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SULT2B1 | sulfotransferase family, cytosolic, 2B, member 1; Sulfotransferase that utilizes 3’-phospho-5’-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of many hormones, neurotransmitters, drugs and xenobiotic compounds. Sulfonation increases the water solubility of most compounds, and therefore their renal excretion, but it can also result in bioactivation to form active metabolites. Sulfates hydroxysteroids like DHEA. Isoform 1 preferentially sulfonates cholesterol, and isoform 2 avidly sulfonates pregnenolone but not cholesterol (365 aa) | |||
STS | steroid sulfatase (microsomal), isozyme S; Conversion of sulfated steroid precursors to estrogens during pregnancy (583 aa) | |||
FDFT1 | farnesyl-diphosphate farnesyltransferase 1 (417 aa) | |||
PRPF19 | PRP19/PSO4 pre-mRNA processing factor 19 homolog (S. cerevisiae); Plays a role in DNA double-strand break (DSB) repair. Binds double-stranded DNA in a sequence-nonspecific manner. Acts as a structural component of the nuclear framework. May also serve as a support for spliceosome binding and activity. Essential for spliceosome assembly in a oligomerization-dependent manner and might also be important for spliceosome stability. May have E3 ubiquitin ligase activity. The PSO4 complex is required in the DNA interstrand cross-links (ICLs) repair process. Component of the PRP19-CDC5L comple [...] (504 aa) | |||
HSD17B7 | hydroxysteroid (17-beta) dehydrogenase 7; Responsible for the reduction of the keto group on the C-3 of sterols (341 aa) | |||
C14orf1 | chromosome 14 open reading frame 1 (140 aa) | |||
CYP27A1 | cytochrome P450, family 27, subfamily A, polypeptide 1; Catalyzes the first step in the oxidation of the side chain of sterol intermediates; the 27-hydroxylation of 5-beta- cholestane-3-alpha,7-alpha,12-alpha-triol. Has also a vitamin D3- 25-hydroxylase activity (531 aa) | |||
MSMO1 | methylsterol monooxygenase 1 (293 aa) | |||
SC5DL | sterol-C5-desaturase (ERG3 delta-5-desaturase homolog, S. cerevisiae)-like; Catalyzes a dehydrogenation to introduce C5-6 double bond into lathosterol (299 aa) | |||
CYP11A1 | cytochrome P450, family 11, subfamily A, polypeptide 1; Catalyzes the side-chain cleavage reaction of cholesterol to pregnenolone (521 aa) | |||
SIGMAR1 | sigma non-opioid intracellular receptor 1 (223 aa) | |||
DIP2C | DIP2 disco-interacting protein 2 homolog C (Drosophila) (1556 aa) | |||
ACSF2 | acyl-CoA synthetase family member 2; Acyl-CoA synthases catalyze the initial reaction in fatty acid metabolism, by forming a thioester with CoA. Has some preference toward medium-chain substrates. Plays a role in adipodyte differentiation (615 aa) | |||
DIP2B | DIP2 disco-interacting protein 2 homolog B (Drosophila) (1576 aa) | |||
CYP7B1 | cytochrome P450, family 7, subfamily B, polypeptide 1 (506 aa) | |||
CHDH | choline dehydrogenase (594 aa) | |||
C5orf4 | chromosome 5 open reading frame 4 (333 aa) | |||
ACSF3 | acyl-CoA synthetase family member 3; Catalyzes the initial reaction in intramitochondrial fatty acid synthesis, by activating malonate and methylmalonate, but not acetate, into their respective CoA thioester. May have some preference toward very-long-chain substrates (576 aa) | |||
SDR42E1 | short chain dehydrogenase/reductase family 42E, member 1 (393 aa) | |||
AGMO | alkylglycerol monooxygenase; Glyceryl-ether monooxygenase that cleaves the O-alkyl bond of ether lipids. Ether lipids are essential components of brain membranes (445 aa) | |||
LSS | lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase); Catalyzes the cyclization of (S)-2,3 oxidosqualene to lanosterol, a reaction that forms the sterol nucleus (732 aa) | |||
CYP17A1 | cytochrome P450, family 17, subfamily A, polypeptide 1; Conversion of pregnenolone and progesterone to their 17- alpha-hydroxylated products and subsequently to dehydroepiandrosterone (DHEA) and androstenedione. Catalyzes both the 17-alpha-hydroxylation and the 17,20-lyase reaction. Involved in sexual development during fetal life and at puberty (508 aa) | |||
NSDHL | NAD(P) dependent steroid dehydrogenase-like (373 aa) | |||
CH25H | cholesterol 25-hydroxylase; Catalyzes the formation of 25-hydroxycholesterol from cholesterol, leading to repress cholesterol biosynthetic enzymes. May play an important role in regulating lipid metabolism by synthesizing a corepressor that blocks sterol regulatory element binding protein (SREBP) processing. In testis, production of 25- hydroxycholesterol by macrophages may play a role in Leydig cell differentiation (272 aa) | |||
DIP2A | DIP2 disco-interacting protein 2 homolog A (Drosophila); May provide positional cues for axon pathfinding and patterning in the central nervous system (1571 aa) | |||
CYP21A2 | cytochrome P450, family 21, subfamily A, polypeptide 2 (495 aa) |