node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CASP3 | CASP7 | ENSP00000311032 | ENSP00000358327 | caspase 3, apoptosis-related cysteine peptidase; Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a ’216-Asp-|-Gly-217’ bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop- helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin. Triggers cell adhesion in sympathetic neurons through RET cleavage | caspase 7, apoptosis-related cysteine peptidase | 0.933 |
CASP7 | CASP3 | ENSP00000358327 | ENSP00000311032 | caspase 7, apoptosis-related cysteine peptidase | caspase 3, apoptosis-related cysteine peptidase; Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a ’216-Asp-|-Gly-217’ bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop- helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin. Triggers cell adhesion in sympathetic neurons through RET cleavage | 0.933 |
CD74 | CTSF | ENSP00000009530 | ENSP00000310832 | CD74 molecule, major histocompatibility complex, class II invariant chain | cathepsin F; Thiol protease which is believed to participate in intracellular degradation and turnover of proteins. Has also been implicated in tumor invasion and metastasis | 0.960 |
CD74 | CTSS | ENSP00000009530 | ENSP00000357981 | CD74 molecule, major histocompatibility complex, class II invariant chain | cathepsin S; Thiol protease. Key protease responsible for the removal of the invariant chain from MHC class II molecules. The bond- specificity of this proteinase is in part similar to the specificities of cathepsin L and cathepsin N | 0.988 |
CD74 | HLA-DRB1 | ENSP00000009530 | ENSP00000353099 | CD74 molecule, major histocompatibility complex, class II invariant chain | major histocompatibility complex, class II, DR beta 1 | 0.915 |
CD74 | HLA-DRB5 | ENSP00000009530 | ENSP00000364114 | CD74 molecule, major histocompatibility complex, class II invariant chain | major histocompatibility complex, class II, DR beta 5 | 0.921 |
CTSF | CD74 | ENSP00000310832 | ENSP00000009530 | cathepsin F; Thiol protease which is believed to participate in intracellular degradation and turnover of proteins. Has also been implicated in tumor invasion and metastasis | CD74 molecule, major histocompatibility complex, class II invariant chain | 0.960 |
CTSF | CTSS | ENSP00000310832 | ENSP00000357981 | cathepsin F; Thiol protease which is believed to participate in intracellular degradation and turnover of proteins. Has also been implicated in tumor invasion and metastasis | cathepsin S; Thiol protease. Key protease responsible for the removal of the invariant chain from MHC class II molecules. The bond- specificity of this proteinase is in part similar to the specificities of cathepsin L and cathepsin N | 0.916 |
CTSF | HLA-DRB1 | ENSP00000310832 | ENSP00000353099 | cathepsin F; Thiol protease which is believed to participate in intracellular degradation and turnover of proteins. Has also been implicated in tumor invasion and metastasis | major histocompatibility complex, class II, DR beta 1 | 0.900 |
CTSF | HLA-DRB5 | ENSP00000310832 | ENSP00000364114 | cathepsin F; Thiol protease which is believed to participate in intracellular degradation and turnover of proteins. Has also been implicated in tumor invasion and metastasis | major histocompatibility complex, class II, DR beta 5 | 0.900 |
CTSF | IFI30 | ENSP00000310832 | ENSP00000384886 | cathepsin F; Thiol protease which is believed to participate in intracellular degradation and turnover of proteins. Has also been implicated in tumor invasion and metastasis | interferon, gamma-inducible protein 30; Lysosomal thiol reductase that can reduce protein disulfide bonds. May facilitate the complete unfolding of proteins destined for lysosomal degradation. Plays an important role in antigen processing. Facilitates the generation of MHC class II- restricted epitodes from disulfide bond-containing antigen by the endocytic reduction of disulfide bonds (By similarity). Facilitates also MHC class I-restricted recognition of exogenous antigens containing disulfide bonds by CD8+ T-cells or crosspresentation (By similarity) | 0.906 |
CTSS | CD74 | ENSP00000357981 | ENSP00000009530 | cathepsin S; Thiol protease. Key protease responsible for the removal of the invariant chain from MHC class II molecules. The bond- specificity of this proteinase is in part similar to the specificities of cathepsin L and cathepsin N | CD74 molecule, major histocompatibility complex, class II invariant chain | 0.988 |
CTSS | CTSF | ENSP00000357981 | ENSP00000310832 | cathepsin S; Thiol protease. Key protease responsible for the removal of the invariant chain from MHC class II molecules. The bond- specificity of this proteinase is in part similar to the specificities of cathepsin L and cathepsin N | cathepsin F; Thiol protease which is believed to participate in intracellular degradation and turnover of proteins. Has also been implicated in tumor invasion and metastasis | 0.916 |
CTSS | HLA-DRB1 | ENSP00000357981 | ENSP00000353099 | cathepsin S; Thiol protease. Key protease responsible for the removal of the invariant chain from MHC class II molecules. The bond- specificity of this proteinase is in part similar to the specificities of cathepsin L and cathepsin N | major histocompatibility complex, class II, DR beta 1 | 0.902 |
CTSS | HLA-DRB5 | ENSP00000357981 | ENSP00000364114 | cathepsin S; Thiol protease. Key protease responsible for the removal of the invariant chain from MHC class II molecules. The bond- specificity of this proteinase is in part similar to the specificities of cathepsin L and cathepsin N | major histocompatibility complex, class II, DR beta 5 | 0.900 |
CTSS | IFI30 | ENSP00000357981 | ENSP00000384886 | cathepsin S; Thiol protease. Key protease responsible for the removal of the invariant chain from MHC class II molecules. The bond- specificity of this proteinase is in part similar to the specificities of cathepsin L and cathepsin N | interferon, gamma-inducible protein 30; Lysosomal thiol reductase that can reduce protein disulfide bonds. May facilitate the complete unfolding of proteins destined for lysosomal degradation. Plays an important role in antigen processing. Facilitates the generation of MHC class II- restricted epitodes from disulfide bond-containing antigen by the endocytic reduction of disulfide bonds (By similarity). Facilitates also MHC class I-restricted recognition of exogenous antigens containing disulfide bonds by CD8+ T-cells or crosspresentation (By similarity) | 0.942 |
HLA-DRB1 | CD74 | ENSP00000353099 | ENSP00000009530 | major histocompatibility complex, class II, DR beta 1 | CD74 molecule, major histocompatibility complex, class II invariant chain | 0.915 |
HLA-DRB1 | CTSF | ENSP00000353099 | ENSP00000310832 | major histocompatibility complex, class II, DR beta 1 | cathepsin F; Thiol protease which is believed to participate in intracellular degradation and turnover of proteins. Has also been implicated in tumor invasion and metastasis | 0.900 |
HLA-DRB1 | CTSS | ENSP00000353099 | ENSP00000357981 | major histocompatibility complex, class II, DR beta 1 | cathepsin S; Thiol protease. Key protease responsible for the removal of the invariant chain from MHC class II molecules. The bond- specificity of this proteinase is in part similar to the specificities of cathepsin L and cathepsin N | 0.902 |
HLA-DRB1 | HLA-DRB5 | ENSP00000353099 | ENSP00000364114 | major histocompatibility complex, class II, DR beta 1 | major histocompatibility complex, class II, DR beta 5 | 0.900 |