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  • 10.0 (archived version)
STRINGSTRING
EGR4 EGR4 ARNT ARNT ARNT2 ARNT2 NPAS4 NPAS4 EGR1 EGR1 ARNTL ARNTL EGR2 EGR2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small protein node
small nodes:
protein of unknown 3D structure
large protein node
large nodes:
some 3D structure is known or predicted
Node Color
colored protein node
colored nodes:
query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
database edge
from curated databases
experiment edge
experimentally determined
Predicted Interactions
neighborhood edge
gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
Others
textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
Your Input:
EGR1early growth response 1; Transcriptional regulator. Recognizes and binds to the DNA sequence 5’-CGCCCCCGC-3’(EGR-site). Activates the transcription of target genes whose products are required for mitogenesis and differentiation (543 aa)
EGR2early growth response 2; Sequence-specific DNA-binding transcription factor. Binds to two specific DNA sites located in the promoter region of HOXA4 (476 aa)
ARNT2aryl-hydrocarbon receptor nuclear translocator 2; Specifically recognizes the xenobiotic response element (XRE) (717 aa)
NPAS4neuronal PAS domain protein 4; Acts as a transcriptional activator in the presence of ARNT. Can activate the CME (CNS midline enhancer) element and the expression of the drebrin gene (802 aa)
ARNTaryl hydrocarbon receptor nuclear translocator; Required for activity of the Ah (dioxin) receptor. This protein is required for the ligand-binding subunit to translocate from the cytosol to the nucleus after ligand binding. The complex then initiates transcription of genes involved in the activation of PAH procarcinogens. The heterodimer with HIF1A or EPAS1/HIF2A functions as a transcriptional regulator of the adaptive response to hypoxia (789 aa)
ARNTLaryl hydrocarbon receptor nuclear translocator-like (625 aa)
EGR4early growth response 4; Transcriptional regulator. Recognizes and binds to the DNA sequence 5’-GCGGGGGCG-3’ (GSG). Activates the transcription of target genes whose products are required for mitogenesis and differentiation (By similarity) (589 aa)
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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