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TPR TPR DNALI1 DNALI1 CCDC114 CCDC114 NTRK1 NTRK1 DNAH2 DNAH2 DNAH14 DNAH14 DNAI1 DNAI1 WDR67 WDR67 DYNC1I1 DYNC1I1 DNAH7 DNAH7 DNAH3 DNAH3 DNAH10 DNAH10 ASB14 ASB14 UBC UBC SNX4 SNX4 DYNC2H1 DYNC2H1 DNAH6 DNAH6 DNAH9 DNAH9 TCTE3 TCTE3 DYNC1H1 DYNC1H1 DNAH8 DNAH8 DCTN2 DCTN2 DNAH1 DNAH1 DNAH17 DNAH17 MAPRE3 MAPRE3 PAFAH1B1 PAFAH1B1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small protein node
small nodes:
protein of unknown 3D structure
large protein node
large nodes:
some 3D structure is known or predicted
Node Color
colored protein node
colored nodes:
query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
database edge
from curated databases
experiment edge
experimentally determined
Predicted Interactions
neighborhood edge
gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
Others
textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
Your Input:
MAPRE3microtubule-associated protein, RP/EB family, member 3; Binds to the plus end of microtubules and regulates the dynamics of the microtubule cytoskeleton. Promotes microtubule growth. May be involved in spindle function by stabilizing microtubules and anchoring them at centrosomes. May play a role in cell migration (By similarity) (281 aa)
DNAH6dynein, axonemal, heavy chain 6 (4158 aa)
DNAI1dynein, axonemal, intermediate chain 1; Part of the dynein complex of respiratory cilia (699 aa)
SNX4sorting nexin 4; May be involved in several stages of intracellular trafficking. Plays a role in recycling endocytosed transferrin receptor and prevent its degradation (450 aa)
DNAH3dynein, axonemal, heavy chain 3 (4116 aa)
DNAH9dynein, axonemal, heavy chain 9; Force generating protein of respiratory cilia. Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP (4486 aa)
WDR67WD repeat domain 67 (1066 aa)
DNALI1dynein, axonemal, light intermediate chain 1; May play a dynamic role in flagellar motility (280 aa)
DNAH7dynein, axonemal, heavy chain 7 (4024 aa)
CCDC114coiled-coil domain containing 114; Probable component of the outer dynein arm complex required along the entire axoneme for tethering of outer dynein arms (Probable) (670 aa)
DYNC1I1dynein, cytoplasmic 1, intermediate chain 1; Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. The intermediate chains mediate the binding of dynein to dynactin via its 150 kDa component (p150- glued) DCNT1. May play a role in mediating the interaction of cytoplasmic dynein with membranous organelles and k [...] (645 aa)
DNAH8dynein, axonemal, heavy chain 8; Force generating protein of respiratory cilia. Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Involved in sperm motility; implicated in sperm flagellar assembly (By similarity) (4695 aa)
UBCubiquitin C (685 aa)
DYNC1H1dynein, cytoplasmic 1, heavy chain 1; Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP (4646 aa)
TCTE3t-complex-associated-testis-expressed 3; May be an accessory component of axonemal dynein and cytoplasmic dynein 1. Candidate for involvement in male sterility (By similarity) (198 aa)
TPRtranslocated promoter region, nuclear basket protein; Component of the nuclear pore complex (NPC), a complex required for the trafficking across the nuclear envelope. Functions as a scaffolding element in the nuclear phase of the NPC essential for normal nucleocytoplasmic transport of proteins and mRNAs, plays a role in the establishment of nuclear-peripheral chromatin compartmentalization in interphase, and in the mitotic spindle checkpoint signaling during mitosis. Involved in the quality control and retention of unspliced mRNAs in the nucleus; in association with NUP153, regulates t [...] (2363 aa)
DNAH2dynein, axonemal, heavy chain 2; Force generating protein of respiratory cilia. Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Involved in sperm motility; implicated in sperm flagellar assembly (By similarity) (4427 aa)
DNAH17dynein, axonemal, heavy chain 17; Force generating protein of respiratory cilia. Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Involved in sperm motility; implicated in sperm flagellar assembly (By similarity) (4485 aa)
PAFAH1B1platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa); Required for proper activation of Rho GTPases and actin polymerization at the leading edge of locomoting cerebellar neurons and postmigratory hippocampal neurons in response to calcium influx triggered via NMDA receptors. Non-catalytic subunit of an acetylhydrolase complex which inactivates platelet- activating factor (PAF) by removing the acetyl group at the SN-2 position (By similarity). Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated [...] (410 aa)
DYNC2H1dynein, cytoplasmic 2, heavy chain 1 (4314 aa)
DNAH14dynein, axonemal, heavy chain 14 (453 aa)
DNAH10dynein, axonemal, heavy chain 10; Force generating protein of respiratory cilia. Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Involved in sperm motility; implicated in sperm flagellar assembly (By similarity). Probable inner arm dynein heavy chain (4471 aa)
DNAH1dynein, axonemal, heavy chain 1 (4265 aa)
DCTN2dynactin 2 (p50); Modulates cytoplasmic dynein binding to an organelle, and plays a role in prometaphase chromosome alignment and spindle organization during mitosis. Involved in anchoring microtubules to centrosomes. May play a role in synapse formation during brain development (406 aa)
ASB14ankyrin repeat and SOCS box containing 14; May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity) (587 aa)
NTRK1neurotrophic tyrosine kinase, receptor, type 1 (796 aa)
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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