Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small nodes:
protein of unknown 3D structure
protein of unknown 3D structure
large nodes:
some 3D structure is known or predicted
some 3D structure is known or predicted
Node Color
colored nodes:
query proteins and first shell of interactors
query proteins and first shell of interactors
white nodes:
second shell of interactors
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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 | TNNC1 | troponin C type 1 (slow); Troponin is the central regulatory protein of striated muscle contraction. Tn consists of three components- Tn-I which is the inhibitor of actomyosin ATPase, Tn-T which contains the binding site for tropomyosin and Tn-C. The binding of calcium to Tn-C abolishes the inhibitory action of Tn on actin filaments (161 aa) | ||
 | OCM | oncomodulin; Has some calmodulin-like activity with respect to enzyme activation and growth regulation. Binds two calcium ions (109 aa) | ||
 | OCM2 | oncomodulin 2 (109 aa) | ||
 | RHBDL3 | rhomboid, veinlet-like 3 (Drosophila); May be involved in regulated intramembrane proteolysis and the subsequent release of functional polypeptides from their membrane anchors (By similarity) (404 aa) | ||
 | CALM2 | calmodulin 2 (phosphorylase kinase, delta) (149 aa) | ||
 | CALM3 | calmodulin 3 (phosphorylase kinase, delta) (149 aa) | ||
 | CABP5 | calcium binding protein 5; Inhibits calcium-dependent inactivation of L-type calcium channel and shifts voltage dependence of activation to more depolarized membrane potentials. Involved in the transmission of light signals (By similarity) (173 aa) | ||
 | CABP2 | calcium binding protein 2 (220 aa) | ||
 | CALML6 | calmodulin-like 6 (181 aa) | ||
 | CALB2 | calbindin 2; Calretinin is a calcium-binding protein which is abundant in auditory neurons (271 aa) | ||
 | SPEG | SPEG complex locus (3267 aa) | ||
 | CALML3 | calmodulin-like 3; May be similar to that of authentic calmodulin and may actually compete with calmodulin by binding, with different affinities, to cellular substrates (149 aa) | ||
 | CABP1 | calcium binding protein 1; Modulates calcium-dependent activity of inositol 1,4,5- triphosphate receptors (ITPRs). Inhibits agonist-induced intracellular calcium signaling. Enhances inactivation and does not support calcium-dependent facilitation of voltage-dependent P/Q-type calcium channels. Causes calcium-dependent facilitation and inhibits inactivation of L-type calcium channels by binding to the same sites as calmodulin in the C-terminal domain of CACNA1C, but resulting in an opposit effects on channel function. Suppresses the calcium-dependent inactivation of CACNA1D (By similari [...] (370 aa) | ||
 | CABP4 | calcium binding protein 4; Involved in normal synaptic function through regulation of Ca(2+) influx and neurotransmitter release in photoreceptor synaptic terminals and in auditory transmission. Modulator of CACNA1D and CACNA1F, suppressing the calcium-dependent inactivation and shifting the activation range to more hyperpolarized voltages (By similarity) (275 aa) | ||
 | EFCAB11 | EF-hand calcium binding domain 11 (163 aa) | ||
 | EFCAB13 | EF-hand calcium binding domain 13 (973 aa) | ||
 | SPATA21 | spermatogenesis associated 21; Involved in the differentiation of haploid spermatids (By similarity) (469 aa) | ||
 | CALM1 | calmodulin 1 (phosphorylase kinase, delta) (149 aa) | ||
 | EFCAB2 | EF-hand calcium binding domain 2 (162 aa) | ||
 | EFCAB7 | EF-hand calcium binding domain 7 (629 aa) | ||
 | TNNC2 | troponin C type 2 (fast); Troponin is the central regulatory protein of striated muscle contraction. Tn consists of three components- Tn-I which is the inhibitor of actomyosin ATPase, Tn-T which contains the binding site for tropomyosin and Tn-C. The binding of calcium to Tn-C abolishes the inhibitory action of Tn on actin filaments (160 aa) | ||
 | SCGN | secretagogin, EF-hand calcium binding protein (276 aa) | ||
 | CALN1 | calneuron 1; Negatively regulates Golgi-to-plasma membrane trafficking by interacting with PI4KB and inhibiting its activity (By similarity). May play a role in the physiology of neurons and is potentially important in memory and learning (261 aa) | ||
 | EFCAB9 | EF-hand calcium binding domain 9 (197 aa) | ||
 | EFCAB3 | EF-hand calcium binding domain 3 (490 aa) | ||
 | CALML4 | calmodulin-like 4 (196 aa) | ||
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
Other names: H. sapiens, Homo, Homo sapiens, human, man
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