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STRINGSTRING
SEC61A2 SEC61A2 SEC61A1 SEC61A1 SSR3 SSR3 RPN2 RPN2 RPN1 RPN1 RPS13 RPS13 SRP68 SRP68 RPS2 RPS2 SRP54 SRP54 TRAM1 TRAM1 SRP14 SRP14 RPL23 RPL23 RPS15A RPS15A RPL10A RPL10A SRP72 SRP72 RPL10L RPL10L RPL21 RPL21 RPLP1 RPLP1 SRP19 SRP19 RPL13 RPL13 RPL35A RPL35A RPL10 RPL10 RPL36 RPL36 RPS7 RPS7 RPS24 RPS24 RPL36AL RPL36AL
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small protein node
small nodes:
protein of unknown 3D structure
large protein node
large nodes:
some 3D structure is known or predicted
Node Color
colored protein node
colored nodes:
query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
database edge
from curated databases
experiment edge
experimentally determined
Predicted Interactions
neighborhood edge
gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
Others
textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
Your Input:
SRP54signal recognition particle 54kDa; Binds to the signal sequence of presecretory protein when they emerge from the ribosomes and transfers them to TRAM (translocating chain-associating membrane protein) (504 aa)
RPN2ribophorin II; Essential subunit of the N-oligosaccharyl transferase (OST) complex which catalyzes the transfer of a high mannose oligosaccharide from a lipid-linked oligosaccharide donor to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains (631 aa)
SEC61A1Sec61 alpha 1 subunit (S. cerevisiae) (476 aa)
RPL36ribosomal protein L36 (105 aa)
TRAM1translocation associated membrane protein 1; Stimulatory or required for the translocation of secretory proteins across the ER membrane (374 aa)
SSR3signal sequence receptor, gamma (translocon-associated protein gamma); TRAP proteins are part of a complex whose function is to bind calcium to the ER membrane and thereby regulate the retention of ER resident proteins (185 aa)
SRP14signal recognition particle 14kDa (homologous Alu RNA binding protein); Signal-recognition-particle assembly has a crucial role in targeting secretory proteins to the rough endoplasmic reticulum membrane. SRP9 together with SRP14 and the Alu portion of the SRP RNA, constitutes the elongation arrest domain of SRP. The complex of SRP9 and SRP14 is required for SRP RNA binding (136 aa)
RPN1ribophorin I; Essential subunit of the N-oligosaccharyl transferase (OST) complex which catalyzes the transfer of a high mannose oligosaccharide from a lipid-linked oligosaccharide donor to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains (607 aa)
RPL10Lribosomal protein L10-like; May play a role in compensating for the inactivated X- linked gene during spermatogenesis (214 aa)
SEC61A2Sec61 alpha 2 subunit (S. cerevisiae); Appears to play a crucial role in the insertion of secretory and membrane polypeptides into the ER. It is required for assembly of membrane and secretory proteins. Found to be tightly associated with membrane-bound ribosomes, either directly or through adaptor proteins (By similarity) (476 aa)
RPL13ribosomal protein L13 (211 aa)
SRP68signal recognition particle 68kDa; Signal-recognition-particle assembly has a crucial role in targeting secretory proteins to the rough endoplasmic reticulum membrane. SRP68 binds the 7S RNA, SRP72 binds to this complex subsequently. This ribonucleoprotein complex might interact directly with the docking protein in the ER membrane and possibly participate in the elongation arrest function (627 aa)
RPS15Aribosomal protein S15a (130 aa)
RPS7ribosomal protein S7; Required for rRNA maturation (194 aa)
RPL10ribosomal protein L10 (214 aa)
RPS2ribosomal protein S2 (293 aa)
SRP72signal recognition particle 72kDa; Signal-recognition-particle assembly has a crucial role in targeting secretory proteins to the rough endoplasmic reticulum membrane. Binds the 7S RNA only in presence of SRP68. This ribonucleoprotein complex might interact directly with the docking protein in the ER membrane and possibly participate in the elongation arrest function (671 aa)
RPL36ALribosomal protein L36a-like (106 aa)
RPL21ribosomal protein L21 (160 aa)
RPLP1ribosomal protein, large, P1; Plays an important role in the elongation step of protein synthesis (114 aa)
RPL10Aribosomal protein L10a (217 aa)
RPL23ribosomal protein L23 (140 aa)
RPL35Aribosomal protein L35a; Required for the proliferation and viability of hematopoietic cells. Plays a role in 60S ribosomal subunit formation. The protein was found to bind to both initiator and elongator tRNAs and consequently was assigned to the P site or P and A site (110 aa)
RPS24ribosomal protein S24; Required for processing of pre-rRNA and maturation of 40S ribosomal subunits (289 aa)
SRP19signal recognition particle 19kDa; Signal-recognition-particle assembly, binds directly to 7S RNA and mediates binding of the 54 kDa subunit of the SRP (144 aa)
RPS13ribosomal protein S13 (151 aa)
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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