node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ATP6V0A1 | MARCKSL1 | ENSP00000264649 | ENSP00000362638 | ATPase, H+ transporting, lysosomal V0 subunit a1; Required for assembly and activity of the vacuolar ATPase. Potential role in differential targeting and regulation of the enzyme for a specific organelle (By similarity) | MARCKS-like 1; Controls cell movement by regulating actin cytoskeleton homeostasis and filopodium and lamellipodium formation. When unphosphorylated, induces cell migration. When phosphorylated by MAPK8, induces actin bundles formation and stabilization, thereby reducing actin plasticity, hence restricting cell movement, including neuronal migration. May also affect cancer cell migration. May be involved in coupling the protein kinase C and calmodulin signal transduction systems (By similarity) | 0.644 |
ATP6V0A1 | MRPL46 | ENSP00000264649 | ENSP00000312311 | ATPase, H+ transporting, lysosomal V0 subunit a1; Required for assembly and activity of the vacuolar ATPase. Potential role in differential targeting and regulation of the enzyme for a specific organelle (By similarity) | mitochondrial ribosomal protein L46 | 0.644 |
EIF3A | EIF3F | ENSP00000358140 | ENSP00000310040 | eukaryotic translation initiation factor 3, subunit A; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2-GTP-methionyl-tRNAi and eIF-5 to form the 43S preinitiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination riboso [...] | eukaryotic translation initiation factor 3, subunit F; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2-GTP-methionyl-tRNAi and eIF-5 to form the 43S preinitiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination riboso [...] | 0.999 |
EIF3A | MRPL46 | ENSP00000358140 | ENSP00000312311 | eukaryotic translation initiation factor 3, subunit A; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2-GTP-methionyl-tRNAi and eIF-5 to form the 43S preinitiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination riboso [...] | mitochondrial ribosomal protein L46 | 0.644 |
EIF3A | MRPS2 | ENSP00000358140 | ENSP00000241600 | eukaryotic translation initiation factor 3, subunit A; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2-GTP-methionyl-tRNAi and eIF-5 to form the 43S preinitiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination riboso [...] | mitochondrial ribosomal protein S2 | 0.499 |
EIF3F | EIF3A | ENSP00000310040 | ENSP00000358140 | eukaryotic translation initiation factor 3, subunit F; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2-GTP-methionyl-tRNAi and eIF-5 to form the 43S preinitiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination riboso [...] | eukaryotic translation initiation factor 3, subunit A; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2-GTP-methionyl-tRNAi and eIF-5 to form the 43S preinitiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination riboso [...] | 0.999 |
EIF3F | MRPL46 | ENSP00000310040 | ENSP00000312311 | eukaryotic translation initiation factor 3, subunit F; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2-GTP-methionyl-tRNAi and eIF-5 to form the 43S preinitiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination riboso [...] | mitochondrial ribosomal protein L46 | 0.873 |
FUBP1 | MRPL46 | ENSP00000359804 | ENSP00000312311 | far upstream element (FUSE) binding protein 1; Regulates MYC expression by binding to a single-stranded far-upstream element (FUSE) upstream of the MYC promoter. May act both as activator and repressor of transcription | mitochondrial ribosomal protein L46 | 0.644 |
MARCKSL1 | ATP6V0A1 | ENSP00000362638 | ENSP00000264649 | MARCKS-like 1; Controls cell movement by regulating actin cytoskeleton homeostasis and filopodium and lamellipodium formation. When unphosphorylated, induces cell migration. When phosphorylated by MAPK8, induces actin bundles formation and stabilization, thereby reducing actin plasticity, hence restricting cell movement, including neuronal migration. May also affect cancer cell migration. May be involved in coupling the protein kinase C and calmodulin signal transduction systems (By similarity) | ATPase, H+ transporting, lysosomal V0 subunit a1; Required for assembly and activity of the vacuolar ATPase. Potential role in differential targeting and regulation of the enzyme for a specific organelle (By similarity) | 0.644 |
MARCKSL1 | MRPL16 | ENSP00000362638 | ENSP00000300151 | MARCKS-like 1; Controls cell movement by regulating actin cytoskeleton homeostasis and filopodium and lamellipodium formation. When unphosphorylated, induces cell migration. When phosphorylated by MAPK8, induces actin bundles formation and stabilization, thereby reducing actin plasticity, hence restricting cell movement, including neuronal migration. May also affect cancer cell migration. May be involved in coupling the protein kinase C and calmodulin signal transduction systems (By similarity) | mitochondrial ribosomal protein L16; Component of the large subunit of mitochondrial ribosome | 0.644 |
MARCKSL1 | MRPL22 | ENSP00000362638 | ENSP00000431040 | MARCKS-like 1; Controls cell movement by regulating actin cytoskeleton homeostasis and filopodium and lamellipodium formation. When unphosphorylated, induces cell migration. When phosphorylated by MAPK8, induces actin bundles formation and stabilization, thereby reducing actin plasticity, hence restricting cell movement, including neuronal migration. May also affect cancer cell migration. May be involved in coupling the protein kinase C and calmodulin signal transduction systems (By similarity) | mitochondrial ribosomal protein L22 | 0.862 |
MARCKSL1 | MRPL46 | ENSP00000362638 | ENSP00000312311 | MARCKS-like 1; Controls cell movement by regulating actin cytoskeleton homeostasis and filopodium and lamellipodium formation. When unphosphorylated, induces cell migration. When phosphorylated by MAPK8, induces actin bundles formation and stabilization, thereby reducing actin plasticity, hence restricting cell movement, including neuronal migration. May also affect cancer cell migration. May be involved in coupling the protein kinase C and calmodulin signal transduction systems (By similarity) | mitochondrial ribosomal protein L46 | 0.862 |
MRPL1 | MRPL13 | ENSP00000315017 | ENSP00000306548 | mitochondrial ribosomal protein L1 | mitochondrial ribosomal protein L13 | 0.986 |
MRPL1 | MRPL15 | ENSP00000315017 | ENSP00000260102 | mitochondrial ribosomal protein L1 | mitochondrial ribosomal protein L15 | 0.968 |
MRPL1 | MRPL16 | ENSP00000315017 | ENSP00000300151 | mitochondrial ribosomal protein L1 | mitochondrial ribosomal protein L16; Component of the large subunit of mitochondrial ribosome | 0.990 |
MRPL1 | MRPL17 | ENSP00000315017 | ENSP00000288937 | mitochondrial ribosomal protein L1 | mitochondrial ribosomal protein L17 | 0.971 |
MRPL1 | MRPL19 | ENSP00000315017 | ENSP00000377486 | mitochondrial ribosomal protein L1 | mitochondrial ribosomal protein L19 | 0.987 |
MRPL1 | MRPL22 | ENSP00000315017 | ENSP00000431040 | mitochondrial ribosomal protein L1 | mitochondrial ribosomal protein L22 | 0.971 |
MRPL1 | MRPL23 | ENSP00000315017 | ENSP00000370930 | mitochondrial ribosomal protein L1 | mitochondrial ribosomal protein L23 | 0.908 |
MRPL1 | MRPL27 | ENSP00000315017 | ENSP00000225969 | mitochondrial ribosomal protein L1 | mitochondrial ribosomal protein L27 | 0.948 |