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EIF3F EIF3F EIF3A EIF3A MRPS2 MRPS2 ATP6V0A1 ATP6V0A1 MRPL43 MRPL43 MRPL17 MRPL17 MRPL33 MRPL33 MRPL13 MRPL13 MRPL16 MRPL16 MARCKSL1 MARCKSL1 MRPL46 MRPL46 MRPL22 MRPL22 MRPL4 MRPL4 MRPL1 MRPL1 MRPL3 MRPL3 MRPL19 MRPL19 MRPL27 MRPL27 MRPL15 MRPL15 MRPL49 MRPL49 MRPL41 MRPL41 MRPL23 MRPL23 MRPL47 MRPL47 MRPL40 MRPL40 SLC25A13 SLC25A13 FUBP1 FUBP1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small protein node
small nodes:
protein of unknown 3D structure
large protein node
large nodes:
some 3D structure is known or predicted
Node Color
colored protein node
colored nodes:
query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
database edge
from curated databases
experiment edge
experimentally determined
Predicted Interactions
neighborhood edge
gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
Others
textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
Your Input:
MRPL27mitochondrial ribosomal protein L27 (148 aa)
MRPS2mitochondrial ribosomal protein S2 (296 aa)
MRPL4mitochondrial ribosomal protein L4 (311 aa)
MRPL15mitochondrial ribosomal protein L15 (296 aa)
ATP6V0A1ATPase, H+ transporting, lysosomal V0 subunit a1; Required for assembly and activity of the vacuolar ATPase. Potential role in differential targeting and regulation of the enzyme for a specific organelle (By similarity) (838 aa)
MRPL3mitochondrial ribosomal protein L3 (348 aa)
MRPL49mitochondrial ribosomal protein L49 (166 aa)
MRPL17mitochondrial ribosomal protein L17 (175 aa)
MRPL33mitochondrial ribosomal protein L33 (65 aa)
MRPL16mitochondrial ribosomal protein L16; Component of the large subunit of mitochondrial ribosome (251 aa)
MRPL13mitochondrial ribosomal protein L13 (178 aa)
EIF3Feukaryotic translation initiation factor 3, subunit F; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2-GTP-methionyl-tRNAi and eIF-5 to form the 43S preinitiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination riboso [...] (357 aa)
MRPL46mitochondrial ribosomal protein L46 (279 aa)
MRPL1mitochondrial ribosomal protein L1 (325 aa)
MRPL40mitochondrial ribosomal protein L40 (206 aa)
MRPL43mitochondrial ribosomal protein L43 (235 aa)
EIF3Aeukaryotic translation initiation factor 3, subunit A; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2-GTP-methionyl-tRNAi and eIF-5 to form the 43S preinitiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination riboso [...] (1382 aa)
FUBP1far upstream element (FUSE) binding protein 1; Regulates MYC expression by binding to a single-stranded far-upstream element (FUSE) upstream of the MYC promoter. May act both as activator and repressor of transcription (644 aa)
MRPL41mitochondrial ribosomal protein L41; Component of the mitochondrial ribosome large subunit. Also involved in apoptosis and cell cycle. Enhances p53/TP53 stability, thereby contributing to p53/TP53-induced apoptosis in response to growth-inhibitory condition. Enhances p53/TP53 translocation to the mitochondria. Has the ability to arrest the cell cycle at the G1 phase, possibly by stabilizing the CDKN1A and CDKN1B (p27Kip1) proteins (137 aa)
MARCKSL1MARCKS-like 1; Controls cell movement by regulating actin cytoskeleton homeostasis and filopodium and lamellipodium formation. When unphosphorylated, induces cell migration. When phosphorylated by MAPK8, induces actin bundles formation and stabilization, thereby reducing actin plasticity, hence restricting cell movement, including neuronal migration. May also affect cancer cell migration. May be involved in coupling the protein kinase C and calmodulin signal transduction systems (By similarity) (195 aa)
MRPL23mitochondrial ribosomal protein L23 (153 aa)
MRPL19mitochondrial ribosomal protein L19 (292 aa)
SLC25A13solute carrier family 25 (aspartate/glutamate carrier), member 13; Catalyzes the calcium-dependent exchange of cytoplasmic glutamate with mitochondrial aspartate across the mitochondrial inner membrane. May have a function in the urea cycle (676 aa)
MRPL47mitochondrial ribosomal protein L47 (250 aa)
MRPL22mitochondrial ribosomal protein L22 (206 aa)
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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