node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ALDH6A1 | TRMT10C | ENSP00000450436 | ENSP00000312356 | aldehyde dehydrogenase 6 family, member A1; Plays a role in valine and pyrimidine metabolism. Binds fatty acyl-CoA | tRNA methyltransferase 10 homolog C (S. cerevisiae); Functions in mitochondrial tRNA maturation. Part of mitochondrial ribonuclease P, an enzyme composed of MRPP1/RG9MTD1, MRPP2/HSD17B10 and MRPP3/KIAA0391, which cleaves tRNA molecules in their 5’-ends | 0.582 |
C22orf28 | TRMT10C | ENSP00000216038 | ENSP00000312356 | chromosome 22 open reading frame 28; Catalytic subunit of the tRNA-splicing ligase complex that acts by directly joining spliced tRNA halves to mature-sized tRNAs by incorporating the precursor-derived splice junction phosphate into the mature tRNA as a canonical 3’,5’- phosphodiester. May act as a RNA ligase with broad substrate specificity, and may function toward other RNAs | tRNA methyltransferase 10 homolog C (S. cerevisiae); Functions in mitochondrial tRNA maturation. Part of mitochondrial ribonuclease P, an enzyme composed of MRPP1/RG9MTD1, MRPP2/HSD17B10 and MRPP3/KIAA0391, which cleaves tRNA molecules in their 5’-ends | 0.579 |
C22orf28 | UBC | ENSP00000216038 | ENSP00000344818 | chromosome 22 open reading frame 28; Catalytic subunit of the tRNA-splicing ligase complex that acts by directly joining spliced tRNA halves to mature-sized tRNAs by incorporating the precursor-derived splice junction phosphate into the mature tRNA as a canonical 3’,5’- phosphodiester. May act as a RNA ligase with broad substrate specificity, and may function toward other RNAs | ubiquitin C | 0.981 |
CARS2 | RARS2 | ENSP00000257347 | ENSP00000358549 | cysteinyl-tRNA synthetase 2, mitochondrial (putative) | arginyl-tRNA synthetase 2, mitochondrial | 0.457 |
CARS2 | SARS2 | ENSP00000257347 | ENSP00000472847 | cysteinyl-tRNA synthetase 2, mitochondrial (putative) | seryl-tRNA synthetase 2, mitochondrial; Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) | 0.653 |
CARS2 | SHMT2 | ENSP00000257347 | ENSP00000333667 | cysteinyl-tRNA synthetase 2, mitochondrial (putative) | serine hydroxymethyltransferase 2 (mitochondrial); Contributes to the de novo mitochondrial thymidylate biosynthesis pathway. Required to prevent uracil accumulation in mtDNA. Interconversion of serine and glycine. Associates with mitochondrial DNA | 0.440 |
CARS2 | TRMT10C | ENSP00000257347 | ENSP00000312356 | cysteinyl-tRNA synthetase 2, mitochondrial (putative) | tRNA methyltransferase 10 homolog C (S. cerevisiae); Functions in mitochondrial tRNA maturation. Part of mitochondrial ribonuclease P, an enzyme composed of MRPP1/RG9MTD1, MRPP2/HSD17B10 and MRPP3/KIAA0391, which cleaves tRNA molecules in their 5’-ends | 0.584 |
CARS2 | UBC | ENSP00000257347 | ENSP00000344818 | cysteinyl-tRNA synthetase 2, mitochondrial (putative) | ubiquitin C | 0.486 |
CLPB | SHMT2 | ENSP00000294053 | ENSP00000333667 | ClpB caseinolytic peptidase B homolog (E. coli); May function as a regulatory ATPase and be related to secretion/protein trafficking process | serine hydroxymethyltransferase 2 (mitochondrial); Contributes to the de novo mitochondrial thymidylate biosynthesis pathway. Required to prevent uracil accumulation in mtDNA. Interconversion of serine and glycine. Associates with mitochondrial DNA | 0.488 |
CLPB | TRMT10C | ENSP00000294053 | ENSP00000312356 | ClpB caseinolytic peptidase B homolog (E. coli); May function as a regulatory ATPase and be related to secretion/protein trafficking process | tRNA methyltransferase 10 homolog C (S. cerevisiae); Functions in mitochondrial tRNA maturation. Part of mitochondrial ribonuclease P, an enzyme composed of MRPP1/RG9MTD1, MRPP2/HSD17B10 and MRPP3/KIAA0391, which cleaves tRNA molecules in their 5’-ends | 0.551 |
CLPB | UBC | ENSP00000294053 | ENSP00000344818 | ClpB caseinolytic peptidase B homolog (E. coli); May function as a regulatory ATPase and be related to secretion/protein trafficking process | ubiquitin C | 0.772 |
EEF1A1 | ETF1 | ENSP00000330054 | ENSP00000353741 | eukaryotic translation elongation factor 1 alpha 1; This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis. With PARP1 and TXK, forms a complex that acts as a T helper 1 (Th1) cell-specific transcription factor and binds the promoter of IFN-gamma to directly regulate its transcription, and is thus involved importantly in Th1 cytokine production | eukaryotic translation termination factor 1; Directs the termination of nascent peptide synthesis (translation) in response to the termination codons UAA, UAG and UGA. Component of the transient SURF complex which recruits UPF1 to stalled ribosomes in the context of nonsense-mediated decay (NMD) of mRNAs containing premature stop codons | 0.868 |
EEF1A1 | SARS2 | ENSP00000330054 | ENSP00000472847 | eukaryotic translation elongation factor 1 alpha 1; This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis. With PARP1 and TXK, forms a complex that acts as a T helper 1 (Th1) cell-specific transcription factor and binds the promoter of IFN-gamma to directly regulate its transcription, and is thus involved importantly in Th1 cytokine production | seryl-tRNA synthetase 2, mitochondrial; Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) | 0.598 |
EEF1A1 | TRMT10C | ENSP00000330054 | ENSP00000312356 | eukaryotic translation elongation factor 1 alpha 1; This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis. With PARP1 and TXK, forms a complex that acts as a T helper 1 (Th1) cell-specific transcription factor and binds the promoter of IFN-gamma to directly regulate its transcription, and is thus involved importantly in Th1 cytokine production | tRNA methyltransferase 10 homolog C (S. cerevisiae); Functions in mitochondrial tRNA maturation. Part of mitochondrial ribonuclease P, an enzyme composed of MRPP1/RG9MTD1, MRPP2/HSD17B10 and MRPP3/KIAA0391, which cleaves tRNA molecules in their 5’-ends | 0.551 |
EEF1A1 | UBC | ENSP00000330054 | ENSP00000344818 | eukaryotic translation elongation factor 1 alpha 1; This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis. With PARP1 and TXK, forms a complex that acts as a T helper 1 (Th1) cell-specific transcription factor and binds the promoter of IFN-gamma to directly regulate its transcription, and is thus involved importantly in Th1 cytokine production | ubiquitin C | 0.999 |
ETF1 | EEF1A1 | ENSP00000353741 | ENSP00000330054 | eukaryotic translation termination factor 1; Directs the termination of nascent peptide synthesis (translation) in response to the termination codons UAA, UAG and UGA. Component of the transient SURF complex which recruits UPF1 to stalled ribosomes in the context of nonsense-mediated decay (NMD) of mRNAs containing premature stop codons | eukaryotic translation elongation factor 1 alpha 1; This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis. With PARP1 and TXK, forms a complex that acts as a T helper 1 (Th1) cell-specific transcription factor and binds the promoter of IFN-gamma to directly regulate its transcription, and is thus involved importantly in Th1 cytokine production | 0.868 |
ETF1 | TRMT10C | ENSP00000353741 | ENSP00000312356 | eukaryotic translation termination factor 1; Directs the termination of nascent peptide synthesis (translation) in response to the termination codons UAA, UAG and UGA. Component of the transient SURF complex which recruits UPF1 to stalled ribosomes in the context of nonsense-mediated decay (NMD) of mRNAs containing premature stop codons | tRNA methyltransferase 10 homolog C (S. cerevisiae); Functions in mitochondrial tRNA maturation. Part of mitochondrial ribonuclease P, an enzyme composed of MRPP1/RG9MTD1, MRPP2/HSD17B10 and MRPP3/KIAA0391, which cleaves tRNA molecules in their 5’-ends | 0.611 |
ETF1 | UBC | ENSP00000353741 | ENSP00000344818 | eukaryotic translation termination factor 1; Directs the termination of nascent peptide synthesis (translation) in response to the termination codons UAA, UAG and UGA. Component of the transient SURF complex which recruits UPF1 to stalled ribosomes in the context of nonsense-mediated decay (NMD) of mRNAs containing premature stop codons | ubiquitin C | 0.937 |
GLUD2 | SHMT2 | ENSP00000327589 | ENSP00000333667 | glutamate dehydrogenase 2; Important for recycling the chief excitatory neurotransmitter, glutamate, during neurotransmission | serine hydroxymethyltransferase 2 (mitochondrial); Contributes to the de novo mitochondrial thymidylate biosynthesis pathway. Required to prevent uracil accumulation in mtDNA. Interconversion of serine and glycine. Associates with mitochondrial DNA | 0.692 |
GLUD2 | TRMT10C | ENSP00000327589 | ENSP00000312356 | glutamate dehydrogenase 2; Important for recycling the chief excitatory neurotransmitter, glutamate, during neurotransmission | tRNA methyltransferase 10 homolog C (S. cerevisiae); Functions in mitochondrial tRNA maturation. Part of mitochondrial ribonuclease P, an enzyme composed of MRPP1/RG9MTD1, MRPP2/HSD17B10 and MRPP3/KIAA0391, which cleaves tRNA molecules in their 5’-ends | 0.551 |