node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CHRNA1 | CHRNA2 | ENSP00000261007 | ENSP00000385026 | cholinergic receptor, nicotinic, alpha 1 (muscle); After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane | cholinergic receptor, nicotinic, alpha 2 (neuronal); After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane | 0.557 |
CHRNA1 | CHRNA3 | ENSP00000261007 | ENSP00000315602 | cholinergic receptor, nicotinic, alpha 1 (muscle); After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane | cholinergic receptor, nicotinic, alpha 3 (neuronal); After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane | 0.557 |
CHRNA1 | CHRNA4 | ENSP00000261007 | ENSP00000359285 | cholinergic receptor, nicotinic, alpha 1 (muscle); After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane | cholinergic receptor, nicotinic, alpha 4 (neuronal); After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane permeable to sodium ions | 0.558 |
CHRNA1 | CHRNA5 | ENSP00000261007 | ENSP00000299565 | cholinergic receptor, nicotinic, alpha 1 (muscle); After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane | cholinergic receptor, nicotinic, alpha 5 (neuronal); After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane | 0.564 |
CHRNA1 | CHRNA6 | ENSP00000261007 | ENSP00000276410 | cholinergic receptor, nicotinic, alpha 1 (muscle); After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane | cholinergic receptor, nicotinic, alpha 6 (neuronal); After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane | 0.556 |
CHRNA1 | CHRNA7 | ENSP00000261007 | ENSP00000407546 | cholinergic receptor, nicotinic, alpha 1 (muscle); After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane | cholinergic receptor, nicotinic, alpha 7 (neuronal); After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. The channel is blocked by alpha-bungarotoxin | 0.563 |
CHRNA1 | CHRNA9 | ENSP00000261007 | ENSP00000312663 | cholinergic receptor, nicotinic, alpha 1 (muscle); After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane | cholinergic receptor, nicotinic, alpha 9 (neuronal); Ionotropic receptor with a probable role in the modulation of auditory stimuli. Agonist binding may induce an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. The channel is permeable to a range of divalent cations including calcium, the influx of which may activate a potassium current which hyperpolarizes the cell membrane. In the ear, this may lead to a reduction in basilar membrane motion, altering the activity of auditory nerve fibers and redu [...] | 0.408 |
CHRNA1 | CHRNB1 | ENSP00000261007 | ENSP00000304290 | cholinergic receptor, nicotinic, alpha 1 (muscle); After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane | cholinergic receptor, nicotinic, beta 1 (muscle); After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane | 0.585 |
CHRNA1 | CHRNB2 | ENSP00000261007 | ENSP00000357461 | cholinergic receptor, nicotinic, alpha 1 (muscle); After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane | cholinergic receptor, nicotinic, beta 2 (neuronal); After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane permeable to sodiun ions | 0.562 |
CHRNA1 | CHRNB3 | ENSP00000261007 | ENSP00000289957 | cholinergic receptor, nicotinic, alpha 1 (muscle); After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane | cholinergic receptor, nicotinic, beta 3 (neuronal); After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane | 0.562 |
CHRNA1 | CHRNB4 | ENSP00000261007 | ENSP00000261751 | cholinergic receptor, nicotinic, alpha 1 (muscle); After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane | cholinergic receptor, nicotinic, beta 4 (neuronal); After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane | 0.562 |
CHRNA1 | CHRND | ENSP00000261007 | ENSP00000258385 | cholinergic receptor, nicotinic, alpha 1 (muscle); After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane | cholinergic receptor, nicotinic, delta (muscle); After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane | 0.920 |
CHRNA1 | CHRNE | ENSP00000261007 | ENSP00000293780 | cholinergic receptor, nicotinic, alpha 1 (muscle); After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane | cholinergic receptor, nicotinic, epsilon (muscle); After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane | 0.827 |
CHRNA1 | CHRNG | ENSP00000261007 | ENSP00000374145 | cholinergic receptor, nicotinic, alpha 1 (muscle); After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane | cholinergic receptor, nicotinic, gamma (muscle); After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane | 0.761 |
CHRNA1 | STXBP5 | ENSP00000261007 | ENSP00000321826 | cholinergic receptor, nicotinic, alpha 1 (muscle); After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane | syntaxin binding protein 5 (tomosyn); Plays a regulatory role in calcium-dependent exocytosis and neurotransmitter release. Inhibits membrane fusion between transport vesicles and the plasma membrane. May modulate the assembly of trans-SNARE complexes between transport vesicles and the plasma membrane. Inhibits translocation of GLUT4 from intracellular vesicles to the plasma membrane. Competes with STXBP1 for STX1 binding (By similarity) | 0.540 |
CHRNA2 | CHRNA1 | ENSP00000385026 | ENSP00000261007 | cholinergic receptor, nicotinic, alpha 2 (neuronal); After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane | cholinergic receptor, nicotinic, alpha 1 (muscle); After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane | 0.557 |
CHRNA2 | CHRNA3 | ENSP00000385026 | ENSP00000315602 | cholinergic receptor, nicotinic, alpha 2 (neuronal); After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane | cholinergic receptor, nicotinic, alpha 3 (neuronal); After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane | 0.902 |
CHRNA2 | CHRNA4 | ENSP00000385026 | ENSP00000359285 | cholinergic receptor, nicotinic, alpha 2 (neuronal); After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane | cholinergic receptor, nicotinic, alpha 4 (neuronal); After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane permeable to sodium ions | 0.903 |
CHRNA2 | CHRNA5 | ENSP00000385026 | ENSP00000299565 | cholinergic receptor, nicotinic, alpha 2 (neuronal); After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane | cholinergic receptor, nicotinic, alpha 5 (neuronal); After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane | 0.748 |
CHRNA2 | CHRNA6 | ENSP00000385026 | ENSP00000276410 | cholinergic receptor, nicotinic, alpha 2 (neuronal); After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane | cholinergic receptor, nicotinic, alpha 6 (neuronal); After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane | 0.728 |