node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CLPTM1L | MRPL47 | ENSP00000313854 | ENSP00000417602 | CLPTM1-like; Enhances cisplatin-mediated apoptosis, when overexpressed | mitochondrial ribosomal protein L47 | 0.644 |
CLPTM1L | PIK3C3 | ENSP00000313854 | ENSP00000262039 | CLPTM1-like; Enhances cisplatin-mediated apoptosis, when overexpressed | phosphatidylinositol 3-kinase, catalytic subunit type 3; Catalytic subunit of the PI3K complex that mediates formation of phosphatidylinositol 3-phosphate which plays a key role in initiation and maturation of autophagosomes. Involved in the transport of lysosomal enzyme precursors to lysosomes. Required for the abcission step in cytokinesis. Required for transport from early to late endosomes | 0.613 |
CLPTM1L | SPTAN1 | ENSP00000313854 | ENSP00000361824 | CLPTM1-like; Enhances cisplatin-mediated apoptosis, when overexpressed | spectrin, alpha, non-erythrocytic 1 | 0.644 |
CLPTM1L | TMEM173 | ENSP00000313854 | ENSP00000331288 | CLPTM1-like; Enhances cisplatin-mediated apoptosis, when overexpressed | transmembrane protein 173; Facilitator of innate immune signaling that acts as a sensor of cytosolic DNA from bacteria and viruses and promotes the production of type I interferon (IFN-alpha and IFN-beta). Innate immune response is triggered in response to non-CpG double- stranded DNA from viruses and bacteria delivered to the cytoplasm. Acts by recognizing and binding cyclic di-GMP (c-di-GMP), a second messenger produced by bacteria, and cyclic GMP-AMP (cGAMP), a messenger produced in response to DNA virus in the cytosol- upon binding of c-di-GMP or cGAMP, autoinhibition is alleviated [...] | 0.459 |
CLPTM1L | UBC | ENSP00000313854 | ENSP00000344818 | CLPTM1-like; Enhances cisplatin-mediated apoptosis, when overexpressed | ubiquitin C | 0.893 |
CLPTM1L | UNC93B1 | ENSP00000313854 | ENSP00000227471 | CLPTM1-like; Enhances cisplatin-mediated apoptosis, when overexpressed | unc-93 homolog B1 (C. elegans); Plays an important role in innate and adaptive immunity by regulating nucleotide-sensing Toll-like receptor (TLR) signaling. Required for the transport of a subset of TLRs (including TLR3, TLR7 and TLR9) from the endoplasmic reticulum to endolysosomes where they can engage pathogen nucleotides and activate signaling cascades. May play a role in autoreactive B- cells removal | 0.447 |
CLPTM1L | UQCRQ | ENSP00000313854 | ENSP00000367934 | CLPTM1-like; Enhances cisplatin-mediated apoptosis, when overexpressed | ubiquinol-cytochrome c reductase, complex III subunit VII, 9.5kDa; This is a component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is part of the mitochondrial respiratory chain. This subunit, together with cytochrome b, binds to ubiquinone | 0.644 |
GK | UBC | ENSP00000368226 | ENSP00000344818 | glycerol kinase; Key enzyme in the regulation of glycerol uptake and metabolism | ubiquitin C | 0.483 |
MRPL47 | CLPTM1L | ENSP00000417602 | ENSP00000313854 | mitochondrial ribosomal protein L47 | CLPTM1-like; Enhances cisplatin-mediated apoptosis, when overexpressed | 0.644 |
MRPL47 | UBC | ENSP00000417602 | ENSP00000344818 | mitochondrial ribosomal protein L47 | ubiquitin C | 0.483 |
PIK3C3 | CLPTM1L | ENSP00000262039 | ENSP00000313854 | phosphatidylinositol 3-kinase, catalytic subunit type 3; Catalytic subunit of the PI3K complex that mediates formation of phosphatidylinositol 3-phosphate which plays a key role in initiation and maturation of autophagosomes. Involved in the transport of lysosomal enzyme precursors to lysosomes. Required for the abcission step in cytokinesis. Required for transport from early to late endosomes | CLPTM1-like; Enhances cisplatin-mediated apoptosis, when overexpressed | 0.613 |
PIK3C3 | UBC | ENSP00000262039 | ENSP00000344818 | phosphatidylinositol 3-kinase, catalytic subunit type 3; Catalytic subunit of the PI3K complex that mediates formation of phosphatidylinositol 3-phosphate which plays a key role in initiation and maturation of autophagosomes. Involved in the transport of lysosomal enzyme precursors to lysosomes. Required for the abcission step in cytokinesis. Required for transport from early to late endosomes | ubiquitin C | 0.760 |
SPTAN1 | CLPTM1L | ENSP00000361824 | ENSP00000313854 | spectrin, alpha, non-erythrocytic 1 | CLPTM1-like; Enhances cisplatin-mediated apoptosis, when overexpressed | 0.644 |
SPTAN1 | UBC | ENSP00000361824 | ENSP00000344818 | spectrin, alpha, non-erythrocytic 1 | ubiquitin C | 0.819 |
TMEM173 | CLPTM1L | ENSP00000331288 | ENSP00000313854 | transmembrane protein 173; Facilitator of innate immune signaling that acts as a sensor of cytosolic DNA from bacteria and viruses and promotes the production of type I interferon (IFN-alpha and IFN-beta). Innate immune response is triggered in response to non-CpG double- stranded DNA from viruses and bacteria delivered to the cytoplasm. Acts by recognizing and binding cyclic di-GMP (c-di-GMP), a second messenger produced by bacteria, and cyclic GMP-AMP (cGAMP), a messenger produced in response to DNA virus in the cytosol- upon binding of c-di-GMP or cGAMP, autoinhibition is alleviated [...] | CLPTM1-like; Enhances cisplatin-mediated apoptosis, when overexpressed | 0.459 |
TMEM173 | UBC | ENSP00000331288 | ENSP00000344818 | transmembrane protein 173; Facilitator of innate immune signaling that acts as a sensor of cytosolic DNA from bacteria and viruses and promotes the production of type I interferon (IFN-alpha and IFN-beta). Innate immune response is triggered in response to non-CpG double- stranded DNA from viruses and bacteria delivered to the cytoplasm. Acts by recognizing and binding cyclic di-GMP (c-di-GMP), a second messenger produced by bacteria, and cyclic GMP-AMP (cGAMP), a messenger produced in response to DNA virus in the cytosol- upon binding of c-di-GMP or cGAMP, autoinhibition is alleviated [...] | ubiquitin C | 0.997 |
UBC | CLPTM1L | ENSP00000344818 | ENSP00000313854 | ubiquitin C | CLPTM1-like; Enhances cisplatin-mediated apoptosis, when overexpressed | 0.893 |
UBC | GK | ENSP00000344818 | ENSP00000368226 | ubiquitin C | glycerol kinase; Key enzyme in the regulation of glycerol uptake and metabolism | 0.483 |
UBC | MRPL47 | ENSP00000344818 | ENSP00000417602 | ubiquitin C | mitochondrial ribosomal protein L47 | 0.483 |
UBC | PIK3C3 | ENSP00000344818 | ENSP00000262039 | ubiquitin C | phosphatidylinositol 3-kinase, catalytic subunit type 3; Catalytic subunit of the PI3K complex that mediates formation of phosphatidylinositol 3-phosphate which plays a key role in initiation and maturation of autophagosomes. Involved in the transport of lysosomal enzyme precursors to lysosomes. Required for the abcission step in cytokinesis. Required for transport from early to late endosomes | 0.760 |