Your Input:
|
||||
CASP14 | caspase 14, apoptosis-related cysteine peptidase; Believed to be a non-apoptotic caspase which is involved in epidermal differentiation. Seems to play a role in keratinocyte differentiation and cornification. Probably regulates maturation of the epidermis by proteolytically processing filaggrin (By similarity) (242 aa) | |||
NOA1 | nitric oxide associated 1; Involved in regulation of mitochondrial protein translation and respiration. Plays a role in mitochondria-mediated cell death. May act as a scaffolding protein or stabilizer of respiratory chain supercomplexes. Binds GTP (698 aa) | |||
CASP6 | caspase 6, apoptosis-related cysteine peptidase; Involved in the activation cascade of caspases responsible for apoptosis execution. Cleaves poly(ADP-ribose) polymerase in vitro, as well as lamins. Overexpression promotes programmed cell death (293 aa) | |||
BCL2A1 | BCL2-related protein A1; Retards apoptosis induced by IL-3 deprivation. May function in the response of hemopoietic cells to external signals and in maintaining endothelial survival during infection (By similarity) (175 aa) | |||
LRGUK | leucine-rich repeats and guanylate kinase domain containing (825 aa) | |||
CASP10 | caspase 10, apoptosis-related cysteine peptidase; Involved in the activation cascade of caspases responsible for apoptosis execution. Recruited to both Fas- and TNFR-1 receptors in a FADD dependent manner. May participate in the granzyme B apoptotic pathways. Cleaves and activates caspase- 3, -4, -6, -7, -8, and -9. Hydrolyzes the small- molecule substrates, Tyr-Val-Ala-Asp-|-AMC and Asp-Glu-Val-Asp-|-AMC (522 aa) | |||
CASP3 | caspase 3, apoptosis-related cysteine peptidase; Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a ’216-Asp-|-Gly-217’ bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop- helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin. Triggers cell adhesion in sympathetic neurons through RET cleavage (277 aa) | |||
CFLAR | CASP8 and FADD-like apoptosis regulator (480 aa) | |||
CASP2 | caspase 2, apoptosis-related cysteine peptidase (452 aa) | |||
BOK | BCL2-related ovarian killer; May play a role in apoptosis (212 aa) | |||
CASP9 | caspase 9, apoptosis-related cysteine peptidase (416 aa) | |||
UBC | ubiquitin C (685 aa) | |||
CASP8 | caspase 8, apoptosis-related cysteine peptidase (538 aa) | |||
PEA15 | phosphoprotein enriched in astrocytes 15; Blocks Ras-mediated inhibition of integrin activation and modulates the ERK MAP kinase cascade. Inhibits RPS6KA3 activities by retaining it in the cytoplasm (By similarity). Inhibits both TNFRSF6- and TNFRSF1A-mediated CASP8 activity and apoptosis. Regulates glucose transport by controlling both the content of SLC2A1 glucose transporters on the plasma membrane and the insulin-dependent trafficking of SLC2A4 from the cell interior to the surface (130 aa) | |||
MCL1 | myeloid cell leukemia sequence 1 (BCL2-related) (350 aa) | |||
CARD16 | caspase recruitment domain family, member 16; Caspase inhibitor. Acts as a regulator of procaspase- 1/CASP1 activation implicated in the regulation of the proteolytic maturation of pro-interleukin-1 beta (IL1B) and its release during inflammation. Inhibits the release of IL1B in response to LPS in monocytes. Also induces NF-kappa-B activation during the pro- inflammatory cytokine response. Also able to inhibit CASP1- mediated neuronal cell death, TNF-alpha, hypoxia-, UV-, and staurosporine-mediated cell death but not ER stress-mediated cell death. Acts by preventing activation of caspa [...] (197 aa) | |||
CARD17 | caspase recruitment domain family, member 17; Regulator of procaspase-1/CASP1 activation implicated in the regulation of the proteolytic maturation of pro-IL-1beta/IL1B and its release during inflammation. Inhibits the release of IL1B in response to LPS in monocytes. However, unlike CASP1, do not induce NF-kappa-B activation (110 aa) | |||
CARD8 | caspase recruitment domain family, member 8; Inhibits NF-kappa-B activation. May participate in a regulatory mechanism that coordinates cellular responses controlled by NF-kappa-B transcription factor. May be a component of the inflammasome, a protein complex which also includes PYCARD, NALP2 and CASP1 and whose function would be the activation of proinflammatory caspases (537 aa) | |||
CASP5 | caspase 5, apoptosis-related cysteine peptidase (447 aa) | |||
FBXO11 | F-box protein 11 (927 aa) | |||
CASP4 | caspase 4, apoptosis-related cysteine peptidase; Involved in the activation cascade of caspases responsible for apoptosis execution. Cleaves caspase-1 (377 aa) | |||
CASP16 | caspase 16, apoptosis-related cysteine peptidase (putative) (183 aa) | |||
CASP1 | caspase 1, apoptosis-related cysteine peptidase; Thiol protease that cleaves IL-1 beta between an Asp and an Ala, releasing the mature cytokine which is involved in a variety of inflammatory processes. Important for defense against pathogens. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Can also promote apoptosis (404 aa) | |||
CASP12 | caspase 12 (gene/pseudogene); Has no protease activity. May reduce cytokine release in response to bacterial lipopolysaccharide during infections. Reduces activation of NF-kappa-B in response to TNF (341 aa) | |||
CARD18 | caspase recruitment domain family, member 18; Inhibits generation of IL-1-beta by interacting with caspase-1 and preventing its association with RIP2. Down-regulates the release of IL1B (90 aa) | |||
APAF1 | apoptotic peptidase activating factor 1 (1248 aa) |