node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ALYREF | UBC | ENSP00000421592 | ENSP00000344818 | Aly/REF export factor; Component of the THO subcomplex of the TREX complex. The TREX complex specifically associates with spliced mRNA and not with unspliced pre-mRNA. It is recruited to spliced mRNAs by a transcription-independent mechanism. Binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5’ end of the mRNA where it functions in mRNA export. The recruitment occurs via an interaction between ALYREF/THOC4 and the cap-binding protein NCBP1. DDX39B functions as a bridge between ALYREF/THOC4 and the THO [...] | ubiquitin C | 0.971 |
ALYREF | WDR35 | ENSP00000421592 | ENSP00000314444 | Aly/REF export factor; Component of the THO subcomplex of the TREX complex. The TREX complex specifically associates with spliced mRNA and not with unspliced pre-mRNA. It is recruited to spliced mRNAs by a transcription-independent mechanism. Binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5’ end of the mRNA where it functions in mRNA export. The recruitment occurs via an interaction between ALYREF/THOC4 and the cap-binding protein NCBP1. DDX39B functions as a bridge between ALYREF/THOC4 and the THO [...] | WD repeat domain 35; Component of the IFT complex A (IFT-A), a complex required for retrograde ciliary transport. Required for ciliogenesis. May promote CASP3 activation and TNF-stimulated apoptosis | 0.644 |
BCL6 | CUL3 | ENSP00000232014 | ENSP00000264414 | B-cell CLL/lymphoma 6; Transcriptional repressor which is required for germinal center formation and antibody affinity maturation. Probably plays an important role in lymphomagenesis | cullin 3; Core component of multiple cullin-RING-based BCR (BTB- CUL3-RBX1) E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The E3 ubiquitin-protein ligase activity of the complex is dependent on the neddylation of the cullin subunit and is inhibited by the association of the deneddylated cullin subunit with TIP120A/CAND1 (By similarity). The functional specificity of the BCR comple [...] | 0.653 |
BCL6 | UBC | ENSP00000232014 | ENSP00000344818 | B-cell CLL/lymphoma 6; Transcriptional repressor which is required for germinal center formation and antibody affinity maturation. Probably plays an important role in lymphomagenesis | ubiquitin C | 0.923 |
CUL3 | BCL6 | ENSP00000264414 | ENSP00000232014 | cullin 3; Core component of multiple cullin-RING-based BCR (BTB- CUL3-RBX1) E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The E3 ubiquitin-protein ligase activity of the complex is dependent on the neddylation of the cullin subunit and is inhibited by the association of the deneddylated cullin subunit with TIP120A/CAND1 (By similarity). The functional specificity of the BCR comple [...] | B-cell CLL/lymphoma 6; Transcriptional repressor which is required for germinal center formation and antibody affinity maturation. Probably plays an important role in lymphomagenesis | 0.653 |
CUL3 | UBC | ENSP00000264414 | ENSP00000344818 | cullin 3; Core component of multiple cullin-RING-based BCR (BTB- CUL3-RBX1) E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The E3 ubiquitin-protein ligase activity of the complex is dependent on the neddylation of the cullin subunit and is inhibited by the association of the deneddylated cullin subunit with TIP120A/CAND1 (By similarity). The functional specificity of the BCR comple [...] | ubiquitin C | 0.999 |
DYNC2LI1 | IFT122 | ENSP00000260605 | ENSP00000296266 | dynein, cytoplasmic 2, light intermediate chain 1 | intraflagellar transport 122 homolog (Chlamydomonas); Required for cilia formation during neuronal patterning. Acts as a negative regulator of Shh signaling. Required to recruit TULP3 to primary cilia (By similarity) | 0.611 |
DYNC2LI1 | IFT140 | ENSP00000260605 | ENSP00000406012 | dynein, cytoplasmic 2, light intermediate chain 1 | intraflagellar transport 140 homolog (Chlamydomonas); Component of the IFT complex A (IFT-A), a complex required for retrograde ciliary transport. Plays a pivotal role in proper development and function of ciliated cells. Involved in ciliogenesis and cilia maintenance | 0.709 |
DYNC2LI1 | IFT27 | ENSP00000260605 | ENSP00000393541 | dynein, cytoplasmic 2, light intermediate chain 1 | intraflagellar transport 27 homolog (Chlamydomonas); Possesses GTPase activity (By similarity) | 0.496 |
DYNC2LI1 | IFT52 | ENSP00000260605 | ENSP00000362121 | dynein, cytoplasmic 2, light intermediate chain 1 | intraflagellar transport 52 homolog (Chlamydomonas) | 0.625 |
DYNC2LI1 | IFT81 | ENSP00000260605 | ENSP00000242591 | dynein, cytoplasmic 2, light intermediate chain 1 | intraflagellar transport 81 homolog (Chlamydomonas); Isoform CDV-1 may be involved in cardiac hypertrophy caused by carnitine deficiency (By similarity) | 0.447 |
DYNC2LI1 | IFT88 | ENSP00000260605 | ENSP00000323580 | dynein, cytoplasmic 2, light intermediate chain 1 | intraflagellar transport 88 homolog (Chlamydomonas); Involved in primary cilium biogenesis (By similarity) | 0.771 |
DYNC2LI1 | TTC21B | ENSP00000260605 | ENSP00000243344 | dynein, cytoplasmic 2, light intermediate chain 1 | tetratricopeptide repeat domain 21B | 0.545 |
DYNC2LI1 | UBC | ENSP00000260605 | ENSP00000344818 | dynein, cytoplasmic 2, light intermediate chain 1 | ubiquitin C | 0.483 |
DYNC2LI1 | WDR19 | ENSP00000260605 | ENSP00000382717 | dynein, cytoplasmic 2, light intermediate chain 1 | WD repeat domain 19; Component of the IFT complex A (IFT-A), a complex required for retrograde ciliary transport. Involved in cilia function and/or assembly (By similarity) | 0.618 |
DYNC2LI1 | WDR35 | ENSP00000260605 | ENSP00000314444 | dynein, cytoplasmic 2, light intermediate chain 1 | WD repeat domain 35; Component of the IFT complex A (IFT-A), a complex required for retrograde ciliary transport. Required for ciliogenesis. May promote CASP3 activation and TNF-stimulated apoptosis | 0.448 |
HSPB11 | IFT122 | ENSP00000194214 | ENSP00000296266 | heat shock protein family B (small), member 11 | intraflagellar transport 122 homolog (Chlamydomonas); Required for cilia formation during neuronal patterning. Acts as a negative regulator of Shh signaling. Required to recruit TULP3 to primary cilia (By similarity) | 0.533 |
HSPB11 | IFT140 | ENSP00000194214 | ENSP00000406012 | heat shock protein family B (small), member 11 | intraflagellar transport 140 homolog (Chlamydomonas); Component of the IFT complex A (IFT-A), a complex required for retrograde ciliary transport. Plays a pivotal role in proper development and function of ciliated cells. Involved in ciliogenesis and cilia maintenance | 0.599 |
HSPB11 | IFT27 | ENSP00000194214 | ENSP00000393541 | heat shock protein family B (small), member 11 | intraflagellar transport 27 homolog (Chlamydomonas); Possesses GTPase activity (By similarity) | 0.997 |
HSPB11 | IFT52 | ENSP00000194214 | ENSP00000362121 | heat shock protein family B (small), member 11 | intraflagellar transport 52 homolog (Chlamydomonas) | 0.657 |