node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
C1QBP | SGSH | ENSP00000225698 | ENSP00000314606 | complement component 1, q subcomponent binding protein; Is believed to be a multifunctional and multicompartmental protein involved in inflammation and infection processes, ribosome biogenesis, regulation of apoptosis, transcriptional regulation and pre-mRNA splicing. At the cell surface is thought to act as an endothelial receptor for plasma proteins of the complement and kallikrein-kinin cascades. Putative receptor for C1q; specifically binds to the globular "heads" of C1q thus inhibiting C1; may perform the receptor function through a complex with C1qR/CD93. In complex with cytokera [...] | N-sulfoglucosamine sulfohydrolase | 0.644 |
C1QBP | UBC | ENSP00000225698 | ENSP00000344818 | complement component 1, q subcomponent binding protein; Is believed to be a multifunctional and multicompartmental protein involved in inflammation and infection processes, ribosome biogenesis, regulation of apoptosis, transcriptional regulation and pre-mRNA splicing. At the cell surface is thought to act as an endothelial receptor for plasma proteins of the complement and kallikrein-kinin cascades. Putative receptor for C1q; specifically binds to the globular "heads" of C1q thus inhibiting C1; may perform the receptor function through a complex with C1qR/CD93. In complex with cytokera [...] | ubiquitin C | 0.904 |
HGSNAT | SGSH | ENSP00000368965 | ENSP00000314606 | heparan-alpha-glucosaminide N-acetyltransferase; Lysosomal acetyltransferase that acetylates the non- reducing terminal alpha-glucosamine residue of intralysosomal heparin or heparan sulfate, converting it into a substrate for luminal alpha-N-acetyl glucosaminidase | N-sulfoglucosamine sulfohydrolase | 0.945 |
IDUA | SGSH | ENSP00000247933 | ENSP00000314606 | iduronidase, alpha-L- | N-sulfoglucosamine sulfohydrolase | 0.974 |
OXCT1 | S100A16 | ENSP00000196371 | ENSP00000357692 | 3-oxoacid CoA transferase 1; Key enzyme for ketone body catabolism. Transfers the CoA moiety from succinate to acetoacetate. Formation of the enzyme-CoA intermediate proceeds via an unstable anhydride species formed between the carboxylate groups of the enzyme and substrate (By similarity) | S100 calcium binding protein A16; Calcium-binding protein. Binds one calcium ion per monomer | 0.906 |
OXCT1 | SGSH | ENSP00000196371 | ENSP00000314606 | 3-oxoacid CoA transferase 1; Key enzyme for ketone body catabolism. Transfers the CoA moiety from succinate to acetoacetate. Formation of the enzyme-CoA intermediate proceeds via an unstable anhydride species formed between the carboxylate groups of the enzyme and substrate (By similarity) | N-sulfoglucosamine sulfohydrolase | 0.653 |
PPT1 | SGSH | ENSP00000394863 | ENSP00000314606 | palmitoyl-protein thioesterase 1; Removes thioester-linked fatty acyl groups such as palmitate from modified cysteine residues in proteins or peptides during lysosomal degradation. Prefers acyl chain lengths of 14 to 18 carbons | N-sulfoglucosamine sulfohydrolase | 0.735 |
PPT1 | UBC | ENSP00000394863 | ENSP00000344818 | palmitoyl-protein thioesterase 1; Removes thioester-linked fatty acyl groups such as palmitate from modified cysteine residues in proteins or peptides during lysosomal degradation. Prefers acyl chain lengths of 14 to 18 carbons | ubiquitin C | 0.803 |
PRDX2 | SGSH | ENSP00000301522 | ENSP00000314606 | peroxiredoxin 2; Involved in redox regulation of the cell. Reduces peroxides with reducing equivalents provided through the thioredoxin system. It is not able to receive electrons from glutaredoxin. May play an important role in eliminating peroxides generated during metabolism. Might participate in the signaling cascades of growth factors and tumor necrosis factor-alpha by regulating the intracellular concentrations of H(2)O(2) | N-sulfoglucosamine sulfohydrolase | 0.677 |
PRDX2 | UBC | ENSP00000301522 | ENSP00000344818 | peroxiredoxin 2; Involved in redox regulation of the cell. Reduces peroxides with reducing equivalents provided through the thioredoxin system. It is not able to receive electrons from glutaredoxin. May play an important role in eliminating peroxides generated during metabolism. Might participate in the signaling cascades of growth factors and tumor necrosis factor-alpha by regulating the intracellular concentrations of H(2)O(2) | ubiquitin C | 0.967 |
RRM1 | SGSH | ENSP00000300738 | ENSP00000314606 | ribonucleotide reductase M1; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) | N-sulfoglucosamine sulfohydrolase | 0.644 |
RRM1 | UBC | ENSP00000300738 | ENSP00000344818 | ribonucleotide reductase M1; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) | ubiquitin C | 0.989 |
S100A16 | OXCT1 | ENSP00000357692 | ENSP00000196371 | S100 calcium binding protein A16; Calcium-binding protein. Binds one calcium ion per monomer | 3-oxoacid CoA transferase 1; Key enzyme for ketone body catabolism. Transfers the CoA moiety from succinate to acetoacetate. Formation of the enzyme-CoA intermediate proceeds via an unstable anhydride species formed between the carboxylate groups of the enzyme and substrate (By similarity) | 0.906 |
S100A16 | SGSH | ENSP00000357692 | ENSP00000314606 | S100 calcium binding protein A16; Calcium-binding protein. Binds one calcium ion per monomer | N-sulfoglucosamine sulfohydrolase | 0.644 |
S100A16 | UBC | ENSP00000357692 | ENSP00000344818 | S100 calcium binding protein A16; Calcium-binding protein. Binds one calcium ion per monomer | ubiquitin C | 0.483 |
SGSH | C1QBP | ENSP00000314606 | ENSP00000225698 | N-sulfoglucosamine sulfohydrolase | complement component 1, q subcomponent binding protein; Is believed to be a multifunctional and multicompartmental protein involved in inflammation and infection processes, ribosome biogenesis, regulation of apoptosis, transcriptional regulation and pre-mRNA splicing. At the cell surface is thought to act as an endothelial receptor for plasma proteins of the complement and kallikrein-kinin cascades. Putative receptor for C1q; specifically binds to the globular "heads" of C1q thus inhibiting C1; may perform the receptor function through a complex with C1qR/CD93. In complex with cytokera [...] | 0.644 |
SGSH | HGSNAT | ENSP00000314606 | ENSP00000368965 | N-sulfoglucosamine sulfohydrolase | heparan-alpha-glucosaminide N-acetyltransferase; Lysosomal acetyltransferase that acetylates the non- reducing terminal alpha-glucosamine residue of intralysosomal heparin or heparan sulfate, converting it into a substrate for luminal alpha-N-acetyl glucosaminidase | 0.945 |
SGSH | IDUA | ENSP00000314606 | ENSP00000247933 | N-sulfoglucosamine sulfohydrolase | iduronidase, alpha-L- | 0.974 |
SGSH | OXCT1 | ENSP00000314606 | ENSP00000196371 | N-sulfoglucosamine sulfohydrolase | 3-oxoacid CoA transferase 1; Key enzyme for ketone body catabolism. Transfers the CoA moiety from succinate to acetoacetate. Formation of the enzyme-CoA intermediate proceeds via an unstable anhydride species formed between the carboxylate groups of the enzyme and substrate (By similarity) | 0.653 |
SGSH | PPT1 | ENSP00000314606 | ENSP00000394863 | N-sulfoglucosamine sulfohydrolase | palmitoyl-protein thioesterase 1; Removes thioester-linked fatty acyl groups such as palmitate from modified cysteine residues in proteins or peptides during lysosomal degradation. Prefers acyl chain lengths of 14 to 18 carbons | 0.735 |