21 items (Homo sapiens) - STRING network view

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Your Input:
	KRT20	keratin 20; Plays a significant role in maintaining keratin filament organization in intestinal epithelia. When phosphorylated, plays a role in the secretion of mucin in the small intestine (By similarity) (424 aa)
	CSNK2A1	casein kinase 2, alpha 1 polypeptide; Catalytic subunit of a constitutively active serine/threonine-protein kinase complex that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine. Regulates numerous cellular processes, such as cell cycle progression, apoptosis and transcription, as well as viral infection. May act as a regulatory node which integrates and coordinates numerous signals leading to an appropriate cellular response. During mitosis, functions as a component of the p53/TP53-dependent spindle assembly che [...] (391 aa)
	VIM	vimentin (466 aa)
	AMOTL2	angiomotin like 2; Regulates the translocation of phosphorylated SRC to peripheral cell-matrix adhesion sites. Required for proper architecture of actin filaments. Inhibits the Wnt/beta-catenin signaling pathway, probably by recruiting CTNNB1 to recycling endosomes and hence preventing its translocation to the nucleus. Participates in angiogenesis. May play a role in the polarity, proliferation and migration of endothelial cells. Selectively promotes FGF-induced MAPK activation through SRC (780 aa)
	CSNK2A2	casein kinase 2, alpha prime polypeptide; Catalytic subunit of a constitutively active serine/threonine-protein kinase complex that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine. Regulates numerous cellular processes, such as cell cycle progression, apoptosis and transcription, as well as viral infection. May act as a regulatory node which integrates and coordinates numerous signals leading to an appropriate cellular response. During mitosis, functions as a component of the p53/TP53-dependent spindle assembly [...] (350 aa)
	MS4A1	membrane-spanning 4-domains, subfamily A, member 1; This protein may be involved in the regulation of B-cell activation and proliferation (297 aa)
	FMNL1	formin-like 1; May play a role in the control of cell motility and survival of macrophages (By similarity). Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the cortical actin filament dynamics and cell shape (1100 aa)
	LCK	lymphocyte-specific protein tyrosine kinase (509 aa)
	FYN	FYN oncogene related to SRC, FGR, YES; Non-receptor tyrosine-protein kinase that plays a role in many biological processes including regulation of cell growth and survival, cell adhesion, integrin-mediated signaling, cytoskeletal remodeling, cell motility, immune response and axon guidance. Inactive FYN is phosphorylated on its C-terminal tail within the catalytic domain. Following activation by PKA, the protein subsequently associates with PTK2/FAK1, allowing PTK2/FAK1 phosphorylation, activation and targeting to focal adhesions. Involved in the regulation of cell adhesion and motilit [...] (537 aa)
	ANKRD36BP1	ankyrin repeat domain 36B pseudogene 1 (119 aa)
	HLA-DRB1	major histocompatibility complex, class II, DR beta 1 (266 aa)
	PRDM1	PR domain containing 1, with ZNF domain; Transcriptional repressor that binds specifically to the PRDI element in the promoter of the beta-interferon gene. Drives the maturation of B-lymphocytes into Ig secreting cells (825 aa)
	CD40	CD40 molecule, TNF receptor superfamily member 5; Receptor for TNFSF5/CD40LG (277 aa)
	C9orf16	chromosome 9 open reading frame 16 (83 aa)
	HLA-DRB5	major histocompatibility complex, class II, DR beta 5 (266 aa)
	PRC1	protein regulator of cytokinesis 1; Key regulator of cytokinesis that cross-links antiparrallel microtubules at an average distance of 35 nM. Essential for controlling the spatiotemporal formation of the midzone and successful cytokinesis. Required for KIF14 localization to the central spindle and midbody. Required to recruit PLK1 to the spindle. Stimulates PLK1 phosphorylation of RACGAP1 to allow recruitment of ECT2 to the central spindle (620 aa)
	KRT80	keratin 80 (452 aa)
	HLA-DRA	major histocompatibility complex, class II, DR alpha (254 aa)
	MDM2	Mdm2, p53 E3 ubiquitin protein ligase homolog (mouse) (497 aa)
	LYN	v-yes-1 Yamaguchi sarcoma viral related oncogene homolog; Non-receptor tyrosine-protein kinase that transmits signals from cell surface receptors and plays an important role in the regulation of innate and adaptive immune responses, hematopoiesis, responses to growth factors and cytokines, integrin signaling, but also responses to DNA damage and genotoxic agents. Functions primarily as negative regulator, but can also function as activator, depending on the context. Required for the initiation of the B-cell response, but also for its down- regulation and termination. Plays an important [...] (512 aa)
	ZC2HC1C	zinc finger, C2HC-type containing 1C (456 aa)

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CD40	LCK	ENSP00000361359	ENSP00000337825	CD40 molecule, TNF receptor superfamily member 5; Receptor for TNFSF5/CD40LG	lymphocyte-specific protein tyrosine kinase	0.513
CD40	LYN	ENSP00000361359	ENSP00000428924	CD40 molecule, TNF receptor superfamily member 5; Receptor for TNFSF5/CD40LG	v-yes-1 Yamaguchi sarcoma viral related oncogene homolog; Non-receptor tyrosine-protein kinase that transmits signals from cell surface receptors and plays an important role in the regulation of innate and adaptive immune responses, hematopoiesis, responses to growth factors and cytokines, integrin signaling, but also responses to DNA damage and genotoxic agents. Functions primarily as negative regulator, but can also function as activator, depending on the context. Required for the initiation of the B-cell response, but also for its down- regulation and termination. Plays an important [...]	0.528
CD40	MS4A1	ENSP00000361359	ENSP00000314620	CD40 molecule, TNF receptor superfamily member 5; Receptor for TNFSF5/CD40LG	membrane-spanning 4-domains, subfamily A, member 1; This protein may be involved in the regulation of B-cell activation and proliferation	0.766
CD40	PRDM1	ENSP00000361359	ENSP00000358092	CD40 molecule, TNF receptor superfamily member 5; Receptor for TNFSF5/CD40LG	PR domain containing 1, with ZNF domain; Transcriptional repressor that binds specifically to the PRDI element in the promoter of the beta-interferon gene. Drives the maturation of B-lymphocytes into Ig secreting cells	0.535
CSNK2A1	CSNK2A2	ENSP00000217244	ENSP00000262506	casein kinase 2, alpha 1 polypeptide; Catalytic subunit of a constitutively active serine/threonine-protein kinase complex that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine. Regulates numerous cellular processes, such as cell cycle progression, apoptosis and transcription, as well as viral infection. May act as a regulatory node which integrates and coordinates numerous signals leading to an appropriate cellular response. During mitosis, functions as a component of the p53/TP53-dependent spindle assembly che [...]	casein kinase 2, alpha prime polypeptide; Catalytic subunit of a constitutively active serine/threonine-protein kinase complex that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine. Regulates numerous cellular processes, such as cell cycle progression, apoptosis and transcription, as well as viral infection. May act as a regulatory node which integrates and coordinates numerous signals leading to an appropriate cellular response. During mitosis, functions as a component of the p53/TP53-dependent spindle assembly [...]	0.788
CSNK2A1	MS4A1	ENSP00000217244	ENSP00000314620	casein kinase 2, alpha 1 polypeptide; Catalytic subunit of a constitutively active serine/threonine-protein kinase complex that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine. Regulates numerous cellular processes, such as cell cycle progression, apoptosis and transcription, as well as viral infection. May act as a regulatory node which integrates and coordinates numerous signals leading to an appropriate cellular response. During mitosis, functions as a component of the p53/TP53-dependent spindle assembly che [...]	membrane-spanning 4-domains, subfamily A, member 1; This protein may be involved in the regulation of B-cell activation and proliferation	0.576
CSNK2A2	CSNK2A1	ENSP00000262506	ENSP00000217244	casein kinase 2, alpha prime polypeptide; Catalytic subunit of a constitutively active serine/threonine-protein kinase complex that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine. Regulates numerous cellular processes, such as cell cycle progression, apoptosis and transcription, as well as viral infection. May act as a regulatory node which integrates and coordinates numerous signals leading to an appropriate cellular response. During mitosis, functions as a component of the p53/TP53-dependent spindle assembly [...]	casein kinase 2, alpha 1 polypeptide; Catalytic subunit of a constitutively active serine/threonine-protein kinase complex that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine. Regulates numerous cellular processes, such as cell cycle progression, apoptosis and transcription, as well as viral infection. May act as a regulatory node which integrates and coordinates numerous signals leading to an appropriate cellular response. During mitosis, functions as a component of the p53/TP53-dependent spindle assembly che [...]	0.788
CSNK2A2	MS4A1	ENSP00000262506	ENSP00000314620	casein kinase 2, alpha prime polypeptide; Catalytic subunit of a constitutively active serine/threonine-protein kinase complex that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine. Regulates numerous cellular processes, such as cell cycle progression, apoptosis and transcription, as well as viral infection. May act as a regulatory node which integrates and coordinates numerous signals leading to an appropriate cellular response. During mitosis, functions as a component of the p53/TP53-dependent spindle assembly [...]	membrane-spanning 4-domains, subfamily A, member 1; This protein may be involved in the regulation of B-cell activation and proliferation	0.576
FYN	HLA-DRB1	ENSP00000346671	ENSP00000353099	FYN oncogene related to SRC, FGR, YES; Non-receptor tyrosine-protein kinase that plays a role in many biological processes including regulation of cell growth and survival, cell adhesion, integrin-mediated signaling, cytoskeletal remodeling, cell motility, immune response and axon guidance. Inactive FYN is phosphorylated on its C-terminal tail within the catalytic domain. Following activation by PKA, the protein subsequently associates with PTK2/FAK1, allowing PTK2/FAK1 phosphorylation, activation and targeting to focal adhesions. Involved in the regulation of cell adhesion and motilit [...]	major histocompatibility complex, class II, DR beta 1	0.900
FYN	LCK	ENSP00000346671	ENSP00000337825	FYN oncogene related to SRC, FGR, YES; Non-receptor tyrosine-protein kinase that plays a role in many biological processes including regulation of cell growth and survival, cell adhesion, integrin-mediated signaling, cytoskeletal remodeling, cell motility, immune response and axon guidance. Inactive FYN is phosphorylated on its C-terminal tail within the catalytic domain. Following activation by PKA, the protein subsequently associates with PTK2/FAK1, allowing PTK2/FAK1 phosphorylation, activation and targeting to focal adhesions. Involved in the regulation of cell adhesion and motilit [...]	lymphocyte-specific protein tyrosine kinase	0.905
FYN	LYN	ENSP00000346671	ENSP00000428924	FYN oncogene related to SRC, FGR, YES; Non-receptor tyrosine-protein kinase that plays a role in many biological processes including regulation of cell growth and survival, cell adhesion, integrin-mediated signaling, cytoskeletal remodeling, cell motility, immune response and axon guidance. Inactive FYN is phosphorylated on its C-terminal tail within the catalytic domain. Following activation by PKA, the protein subsequently associates with PTK2/FAK1, allowing PTK2/FAK1 phosphorylation, activation and targeting to focal adhesions. Involved in the regulation of cell adhesion and motilit [...]	v-yes-1 Yamaguchi sarcoma viral related oncogene homolog; Non-receptor tyrosine-protein kinase that transmits signals from cell surface receptors and plays an important role in the regulation of innate and adaptive immune responses, hematopoiesis, responses to growth factors and cytokines, integrin signaling, but also responses to DNA damage and genotoxic agents. Functions primarily as negative regulator, but can also function as activator, depending on the context. Required for the initiation of the B-cell response, but also for its down- regulation and termination. Plays an important [...]	0.905
FYN	MS4A1	ENSP00000346671	ENSP00000314620	FYN oncogene related to SRC, FGR, YES; Non-receptor tyrosine-protein kinase that plays a role in many biological processes including regulation of cell growth and survival, cell adhesion, integrin-mediated signaling, cytoskeletal remodeling, cell motility, immune response and axon guidance. Inactive FYN is phosphorylated on its C-terminal tail within the catalytic domain. Following activation by PKA, the protein subsequently associates with PTK2/FAK1, allowing PTK2/FAK1 phosphorylation, activation and targeting to focal adhesions. Involved in the regulation of cell adhesion and motilit [...]	membrane-spanning 4-domains, subfamily A, member 1; This protein may be involved in the regulation of B-cell activation and proliferation	0.628
HLA-DRA	HLA-DRB1	ENSP00000378786	ENSP00000353099	major histocompatibility complex, class II, DR alpha	major histocompatibility complex, class II, DR beta 1	0.705
HLA-DRA	HLA-DRB5	ENSP00000378786	ENSP00000364114	major histocompatibility complex, class II, DR alpha	major histocompatibility complex, class II, DR beta 5	0.711
HLA-DRA	MS4A1	ENSP00000378786	ENSP00000314620	major histocompatibility complex, class II, DR alpha	membrane-spanning 4-domains, subfamily A, member 1; This protein may be involved in the regulation of B-cell activation and proliferation	0.778
HLA-DRB1	FYN	ENSP00000353099	ENSP00000346671	major histocompatibility complex, class II, DR beta 1	FYN oncogene related to SRC, FGR, YES; Non-receptor tyrosine-protein kinase that plays a role in many biological processes including regulation of cell growth and survival, cell adhesion, integrin-mediated signaling, cytoskeletal remodeling, cell motility, immune response and axon guidance. Inactive FYN is phosphorylated on its C-terminal tail within the catalytic domain. Following activation by PKA, the protein subsequently associates with PTK2/FAK1, allowing PTK2/FAK1 phosphorylation, activation and targeting to focal adhesions. Involved in the regulation of cell adhesion and motilit [...]	0.900
HLA-DRB1	HLA-DRA	ENSP00000353099	ENSP00000378786	major histocompatibility complex, class II, DR beta 1	major histocompatibility complex, class II, DR alpha	0.705
HLA-DRB1	HLA-DRB5	ENSP00000353099	ENSP00000364114	major histocompatibility complex, class II, DR beta 1	major histocompatibility complex, class II, DR beta 5	0.900
HLA-DRB1	LCK	ENSP00000353099	ENSP00000337825	major histocompatibility complex, class II, DR beta 1	lymphocyte-specific protein tyrosine kinase	0.901
HLA-DRB5	HLA-DRA	ENSP00000364114	ENSP00000378786	major histocompatibility complex, class II, DR beta 5	major histocompatibility complex, class II, DR alpha	0.711

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