node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ALOX12B | ALOXE3 | ENSP00000315167 | ENSP00000314879 | arachidonate 12-lipoxygenase, 12R type; Converts arachidonic acid to 12R- hydroperoxyeicosatetraenoic acid (12R-HPETE) | arachidonate lipoxygenase 3; Introduces molecular oxygen into polyunsaturated fatty acids. Exact substrate is not known | 0.596 |
ALOX12B | TGM1 | ENSP00000315167 | ENSP00000206765 | arachidonate 12-lipoxygenase, 12R type; Converts arachidonic acid to 12R- hydroperoxyeicosatetraenoic acid (12R-HPETE) | transglutaminase 1 (K polypeptide epidermal type I, protein-glutamine-gamma-glutamyltransferase); Catalyzes the cross-linking of proteins and the conjugation of polyamines to proteins. Responsible for cross- linking epidermal proteins during formation of the stratum corneum | 0.849 |
ALOXE3 | ALOX12B | ENSP00000314879 | ENSP00000315167 | arachidonate lipoxygenase 3; Introduces molecular oxygen into polyunsaturated fatty acids. Exact substrate is not known | arachidonate 12-lipoxygenase, 12R type; Converts arachidonic acid to 12R- hydroperoxyeicosatetraenoic acid (12R-HPETE) | 0.596 |
ALOXE3 | COTL1 | ENSP00000314879 | ENSP00000262428 | arachidonate lipoxygenase 3; Introduces molecular oxygen into polyunsaturated fatty acids. Exact substrate is not known | coactosin-like 1 (Dictyostelium); Binds to F-actin in a calcium-independent manner. Has no direct effect on actin depolymerization. Acts as a chaperone for ALOX5 (5LO), influencing both its stability and activity in leukotrienes synthesis | 0.569 |
ALOXE3 | ITGB4 | ENSP00000314879 | ENSP00000200181 | arachidonate lipoxygenase 3; Introduces molecular oxygen into polyunsaturated fatty acids. Exact substrate is not known | integrin, beta 4; Integrin alpha-6/beta-4 is a receptor for laminin. Plays a critical structural role in the hemidesmosome of epithelial cells. Is required for the regulation of keratinocyte polarity and motility | 0.570 |
ALOXE3 | TGM1 | ENSP00000314879 | ENSP00000206765 | arachidonate lipoxygenase 3; Introduces molecular oxygen into polyunsaturated fatty acids. Exact substrate is not known | transglutaminase 1 (K polypeptide epidermal type I, protein-glutamine-gamma-glutamyltransferase); Catalyzes the cross-linking of proteins and the conjugation of polyamines to proteins. Responsible for cross- linking epidermal proteins during formation of the stratum corneum | 0.857 |
ALOXE3 | UBC | ENSP00000314879 | ENSP00000344818 | arachidonate lipoxygenase 3; Introduces molecular oxygen into polyunsaturated fatty acids. Exact substrate is not known | ubiquitin C | 0.620 |
ALOXE3 | VPS39 | ENSP00000314879 | ENSP00000326534 | arachidonate lipoxygenase 3; Introduces molecular oxygen into polyunsaturated fatty acids. Exact substrate is not known | vacuolar protein sorting 39 homolog (S. cerevisiae); May play a role in clustering and fusion of late endosomes and lysosomes. Regulator of TGF-beta/activin signaling, inhibiting SMAD3- and activating SMAD2-dependent transcription. Acts by interfering with SMAD3/SMAD4 complex formation, this would lead to inhibition of SMAD3-dependent transcription and relieve SMAD3 inhibition of SMAD2-dependent promoters, thus increasing SMAD2-dependent transcription. Does not affect TGF-beta-induced SMAD2 or SMAD3 phosphorylation, nor SMAD2/SMAD4 complex formation | 0.569 |
COTL1 | ALOXE3 | ENSP00000262428 | ENSP00000314879 | coactosin-like 1 (Dictyostelium); Binds to F-actin in a calcium-independent manner. Has no direct effect on actin depolymerization. Acts as a chaperone for ALOX5 (5LO), influencing both its stability and activity in leukotrienes synthesis | arachidonate lipoxygenase 3; Introduces molecular oxygen into polyunsaturated fatty acids. Exact substrate is not known | 0.569 |
COTL1 | UBC | ENSP00000262428 | ENSP00000344818 | coactosin-like 1 (Dictyostelium); Binds to F-actin in a calcium-independent manner. Has no direct effect on actin depolymerization. Acts as a chaperone for ALOX5 (5LO), influencing both its stability and activity in leukotrienes synthesis | ubiquitin C | 0.724 |
ITGB4 | ALOXE3 | ENSP00000200181 | ENSP00000314879 | integrin, beta 4; Integrin alpha-6/beta-4 is a receptor for laminin. Plays a critical structural role in the hemidesmosome of epithelial cells. Is required for the regulation of keratinocyte polarity and motility | arachidonate lipoxygenase 3; Introduces molecular oxygen into polyunsaturated fatty acids. Exact substrate is not known | 0.570 |
ITGB4 | UBC | ENSP00000200181 | ENSP00000344818 | integrin, beta 4; Integrin alpha-6/beta-4 is a receptor for laminin. Plays a critical structural role in the hemidesmosome of epithelial cells. Is required for the regulation of keratinocyte polarity and motility | ubiquitin C | 0.633 |
TGM1 | ALOX12B | ENSP00000206765 | ENSP00000315167 | transglutaminase 1 (K polypeptide epidermal type I, protein-glutamine-gamma-glutamyltransferase); Catalyzes the cross-linking of proteins and the conjugation of polyamines to proteins. Responsible for cross- linking epidermal proteins during formation of the stratum corneum | arachidonate 12-lipoxygenase, 12R type; Converts arachidonic acid to 12R- hydroperoxyeicosatetraenoic acid (12R-HPETE) | 0.849 |
TGM1 | ALOXE3 | ENSP00000206765 | ENSP00000314879 | transglutaminase 1 (K polypeptide epidermal type I, protein-glutamine-gamma-glutamyltransferase); Catalyzes the cross-linking of proteins and the conjugation of polyamines to proteins. Responsible for cross- linking epidermal proteins during formation of the stratum corneum | arachidonate lipoxygenase 3; Introduces molecular oxygen into polyunsaturated fatty acids. Exact substrate is not known | 0.857 |
UBC | ALOXE3 | ENSP00000344818 | ENSP00000314879 | ubiquitin C | arachidonate lipoxygenase 3; Introduces molecular oxygen into polyunsaturated fatty acids. Exact substrate is not known | 0.620 |
UBC | COTL1 | ENSP00000344818 | ENSP00000262428 | ubiquitin C | coactosin-like 1 (Dictyostelium); Binds to F-actin in a calcium-independent manner. Has no direct effect on actin depolymerization. Acts as a chaperone for ALOX5 (5LO), influencing both its stability and activity in leukotrienes synthesis | 0.724 |
UBC | ITGB4 | ENSP00000344818 | ENSP00000200181 | ubiquitin C | integrin, beta 4; Integrin alpha-6/beta-4 is a receptor for laminin. Plays a critical structural role in the hemidesmosome of epithelial cells. Is required for the regulation of keratinocyte polarity and motility | 0.633 |
UBC | VPS39 | ENSP00000344818 | ENSP00000326534 | ubiquitin C | vacuolar protein sorting 39 homolog (S. cerevisiae); May play a role in clustering and fusion of late endosomes and lysosomes. Regulator of TGF-beta/activin signaling, inhibiting SMAD3- and activating SMAD2-dependent transcription. Acts by interfering with SMAD3/SMAD4 complex formation, this would lead to inhibition of SMAD3-dependent transcription and relieve SMAD3 inhibition of SMAD2-dependent promoters, thus increasing SMAD2-dependent transcription. Does not affect TGF-beta-induced SMAD2 or SMAD3 phosphorylation, nor SMAD2/SMAD4 complex formation | 0.483 |
VPS39 | ALOXE3 | ENSP00000326534 | ENSP00000314879 | vacuolar protein sorting 39 homolog (S. cerevisiae); May play a role in clustering and fusion of late endosomes and lysosomes. Regulator of TGF-beta/activin signaling, inhibiting SMAD3- and activating SMAD2-dependent transcription. Acts by interfering with SMAD3/SMAD4 complex formation, this would lead to inhibition of SMAD3-dependent transcription and relieve SMAD3 inhibition of SMAD2-dependent promoters, thus increasing SMAD2-dependent transcription. Does not affect TGF-beta-induced SMAD2 or SMAD3 phosphorylation, nor SMAD2/SMAD4 complex formation | arachidonate lipoxygenase 3; Introduces molecular oxygen into polyunsaturated fatty acids. Exact substrate is not known | 0.569 |
VPS39 | UBC | ENSP00000326534 | ENSP00000344818 | vacuolar protein sorting 39 homolog (S. cerevisiae); May play a role in clustering and fusion of late endosomes and lysosomes. Regulator of TGF-beta/activin signaling, inhibiting SMAD3- and activating SMAD2-dependent transcription. Acts by interfering with SMAD3/SMAD4 complex formation, this would lead to inhibition of SMAD3-dependent transcription and relieve SMAD3 inhibition of SMAD2-dependent promoters, thus increasing SMAD2-dependent transcription. Does not affect TGF-beta-induced SMAD2 or SMAD3 phosphorylation, nor SMAD2/SMAD4 complex formation | ubiquitin C | 0.483 |