Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small nodes:
protein of unknown 3D structure
protein of unknown 3D structure
large nodes:
some 3D structure is known or predicted
some 3D structure is known or predicted
Node Color
colored nodes:
query proteins and first shell of interactors
query proteins and first shell of interactors
white nodes:
second shell of interactors
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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 | P2RY10 | purinergic receptor P2Y, G-protein coupled, 10; Putative receptor for purines coupled to G-proteins (339 aa) | ||
 | GNRH2 | gonadotropin-releasing hormone 2; Stimulates the secretion of gonadotropins; it stimulates the secretion of both luteinizing and follicle-stimulating hormones (120 aa) | ||
 | F2RL3 | coagulation factor II (thrombin) receptor-like 3; Receptor for activated thrombin or trypsin coupled to G proteins that stimulate phosphoinositide hydrolysis. May play a role in platelets activation (385 aa) | ||
 | NMU | neuromedin U; Stimulates muscle contractions of specific regions of the gastrointestinal tract. In humans, NmU stimulates contractions of the ileum and urinary bladder (174 aa) | ||
 | NPFF | neuropeptide FF-amide peptide precursor; Morphine modulating peptides. Have wide-ranging physiologic effects, including the modulation of morphine-induced analgesia, elevation of arterial blood pressure, and increased somatostatin secretion from the pancreas. Neuropeptide FF potentiates and sensitizes ASIC1 and ASIC3 channels (113 aa) | ||
 | GRM1 | glutamate receptor, metabotropic 1 (1194 aa) | ||
 | COL1A2 | collagen, type I, alpha 2 (1366 aa) | ||
 | TRH | thyrotropin-releasing hormone; Functions as a regulator of the biosynthesis of TSH in the anterior pituitary gland and as a neurotransmitter/ neuromodulator in the central and peripheral nervous systems. May promote hair shaft elongation, prolonge the hair cycle growth phase (anagen) and antagonized its termination by TGFB2. May also increase proliferation and inhibited apoptosis of hair matrix keratinocytes (242 aa) | ||
 | TACR1 | tachykinin receptor 1; This is a receptor for the tachykinin neuropeptide substance P. It is probably associated with G proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of affinity of this receptor to tachykinins is- substance P > substance K > neuromedin-K (407 aa) | ||
 | ADRA1B | adrenoceptor alpha 1B; This alpha-adrenergic receptor mediates its action by association with G proteins that activate a phosphatidylinositol- calcium second messenger system. Its effect is mediated by G(q) and G(11) proteins. Nuclear ADRA1A-ADRA1B heterooligomers regulate phenylephrine (PE)-stimulated ERK signaling in cardiac myocytes (520 aa) | ||
 | XCR1 | chemokine (C motif) receptor 1; Receptor for chemokines SCYC1 and SCYC2. Subsequently transduces a signal by increasing the intracellular calcium ions level (333 aa) | ||
 | EDNRA | endothelin receptor type A (427 aa) | ||
 | MMP1 | matrix metallopeptidase 1 (interstitial collagenase); Cleaves collagens of types I, II, and III at one site in the helical domain. Also cleaves collagens of types VII and X. In case of HIV infection, interacts and cleaves the secreted viral Tat protein, leading to a decrease in neuronal Tat’s mediated neurotoxicity (469 aa) | ||
 | OXTR | oxytocin receptor; Receptor for oxytocin. The activity of this receptor is mediated by G proteins which activate a phosphatidylinositol- calcium second messenger system (389 aa) | ||
 | RGS19 | regulator of G-protein signaling 19; Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds to G-alpha subfamily 1 members, with the order G(i)a3 > G(i)a1 > G(o)a >> G(z)a/G(i)a2. Activity on G(z)-alpha is inhibited by phosphorylation and palmitoylation of the G-protein (217 aa) | ||
 | FPR2 | formyl peptide receptor 2; Low affinity receptor for N-formyl-methionyl peptides, which are powerful neutrophils chemotactic factors. Binding of FMLP to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system. The activation of LXA4R could result in an anti-inflammatory outcome counteracting the actions of proinflammatory signals such as LTB4 (leukotriene B4) (351 aa) | ||
 | NPSR1 | neuropeptide S receptor 1 (377 aa) | ||
 | RGS18 | regulator of G-protein signaling 18; Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds to G(i) alpha-1, G(i) alpha- 2, G(i) alpha-3 and G(q) alpha (235 aa) | ||
 | XCL2 | chemokine (C motif) ligand 2; Chemotactic activity for lymphocytes but not for monocytes or neutrophils (By similarity) (114 aa) | ||
 | NTSR1 | neurotensin receptor 1 (high affinity); Receptor for the tridecapeptide neurotensin. It is associated with G proteins that activate a phosphatidylinositol- calcium second messenger system (418 aa) | ||
 | OPN4 | opsin 4; Photoreceptor required for regulation of circadian rhythm. Contributes to pupillar reflex and other non-image forming responses to light. May be able to isomerize covalently bound all- trans retinal back to 11-cis retinal (By similarity) (489 aa) | ||
 | EDNRB | endothelin receptor type B (532 aa) | ||
 | EDN1 | endothelin 1; Endothelins are endothelium-derived vasoconstrictor peptides (212 aa) | ||
 | ADRA1D | adrenoceptor alpha 1D; This alpha-adrenergic receptor mediates its effect through the influx of extracellular calcium (572 aa) | ||
 | NMB | neuromedin B; Stimulates smooth muscle contraction in a manner similar to that of bombesin (154 aa) | ||
 | LPAR2 | lysophosphatidic acid receptor 2; Receptor for lysophosphatidic acid (LPA), a mediator of diverse cellular activities. Seems to be coupled to the G(i)/G(o), G(12)/G(13), and G(q) families of heteromeric G proteins. Plays a key role in phospholipase C-beta (PLC-beta) signaling pathway. Stimulates phospholipase C (PLC) activity in a manner that is independent of RALA activation (351 aa) | ||
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
Other names: H. sapiens, Homo, Homo sapiens, human, man
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