node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
DDX54 | EIF6 | ENSP00000323858 | ENSP00000363559 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 54; Has RNA-dependent ATPase activity. Represses the transcriptional activity of nuclear receptors | eukaryotic translation initiation factor 6; Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. May behave as a stimulatory translation initiation factor downstream insulin/growth factors. Is also involved in ribosome biogenesis. Associates with pre-60S subunits in the nucleus and is involved in its nuclear export. Cytoplasmic release of TIF6 from 60S subunits and nuclear relocalization is promoted by a RACK1 (GNB2L1)-dependent protein kinase C activity | 0.949 |
DDX54 | GTPBP4 | ENSP00000323858 | ENSP00000354040 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 54; Has RNA-dependent ATPase activity. Represses the transcriptional activity of nuclear receptors | GTP binding protein 4; Involved in the biogenesis of the 60S ribosomal subunit (By similarity) | 0.980 |
DDX54 | MDN1 | ENSP00000323858 | ENSP00000358400 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 54; Has RNA-dependent ATPase activity. Represses the transcriptional activity of nuclear receptors | MDN1, midasin homolog (yeast); Nuclear chaperone required for maturation and nuclear export of pre-60S ribosome subunits (By similarity) | 0.585 |
DDX54 | METAP1D | ENSP00000323858 | ENSP00000315152 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 54; Has RNA-dependent ATPase activity. Represses the transcriptional activity of nuclear receptors | methionyl aminopeptidase type 1D (mitochondrial); Removes the N-terminal methionine from nascent proteins (By similarity). May play a role in colon tumorigenesis | 0.413 |
DDX54 | METAP2 | ENSP00000323858 | ENSP00000325312 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 54; Has RNA-dependent ATPase activity. Represses the transcriptional activity of nuclear receptors | methionyl aminopeptidase 2; Removes the N-terminal methionine from nascent proteins. The catalytic activity of human METAP2 toward Met-Val peptides is consistently two orders of magnitude higher than that of METAP1, suggesting that it is responsible for processing proteins containing N-terminal Met-Val and Met-Thr sequences in vivo | 0.413 |
DDX54 | MKI67IP | ENSP00000323858 | ENSP00000285814 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 54; Has RNA-dependent ATPase activity. Represses the transcriptional activity of nuclear receptors | MKI67 (FHA domain) interacting nucleolar phosphoprotein | 0.987 |
DDX54 | NIP7 | ENSP00000323858 | ENSP00000254940 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 54; Has RNA-dependent ATPase activity. Represses the transcriptional activity of nuclear receptors | nuclear import 7 homolog (S. cerevisiae); Required for proper 34S pre-rRNA processing and 60S ribosome subunit assembly | 0.957 |
DDX54 | NMD3 | ENSP00000323858 | ENSP00000307525 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 54; Has RNA-dependent ATPase activity. Represses the transcriptional activity of nuclear receptors | NMD3 homolog (S. cerevisiae); Acts as an adapter for the XPO1/CRM1-mediated export of the 60S ribosomal subunit | 0.799 |
DDX54 | PES1 | ENSP00000323858 | ENSP00000346725 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 54; Has RNA-dependent ATPase activity. Represses the transcriptional activity of nuclear receptors | pescadillo ribosomal biogenesis factor 1; Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome | 0.994 |
DDX54 | RPF2 | ENSP00000323858 | ENSP00000402338 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 54; Has RNA-dependent ATPase activity. Represses the transcriptional activity of nuclear receptors | ribosome production factor 2 homolog (S. cerevisiae) | 0.992 |
DDX54 | RPL23A | ENSP00000323858 | ENSP00000389103 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 54; Has RNA-dependent ATPase activity. Represses the transcriptional activity of nuclear receptors | ribosomal protein L23a; This protein binds to a specific region on the 26S rRNA (By similarity) | 0.737 |
DDX54 | RPL5 | ENSP00000323858 | ENSP00000359345 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 54; Has RNA-dependent ATPase activity. Represses the transcriptional activity of nuclear receptors | ribosomal protein L5; Required for rRNA maturation and formation of the 60S ribosomal subunits. This protein binds 5S RNA | 0.828 |
DDX54 | SDAD1 | ENSP00000323858 | ENSP00000348596 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 54; Has RNA-dependent ATPase activity. Represses the transcriptional activity of nuclear receptors | SDA1 domain containing 1; Required for 60S pre-ribosomal subunits export to the cytoplasm (By similarity) | 0.900 |
DNAJC21 | NMD3 | ENSP00000371451 | ENSP00000307525 | DnaJ (Hsp40) homolog, subfamily C, member 21; May act as a co-chaperone for HSP70 | NMD3 homolog (S. cerevisiae); Acts as an adapter for the XPO1/CRM1-mediated export of the 60S ribosomal subunit | 0.914 |
DNAJC21 | ZNF622 | ENSP00000371451 | ENSP00000310042 | DnaJ (Hsp40) homolog, subfamily C, member 21; May act as a co-chaperone for HSP70 | zinc finger protein 622; May behave as an activator of the bound transcription factor, MYBL2, and be involved in embryonic development | 0.935 |
EIF6 | DDX54 | ENSP00000363559 | ENSP00000323858 | eukaryotic translation initiation factor 6; Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. May behave as a stimulatory translation initiation factor downstream insulin/growth factors. Is also involved in ribosome biogenesis. Associates with pre-60S subunits in the nucleus and is involved in its nuclear export. Cytoplasmic release of TIF6 from 60S subunits and nuclear relocalization is promoted by a RACK1 (GNB2L1)-dependent protein kinase C activity | DEAD (Asp-Glu-Ala-Asp) box polypeptide 54; Has RNA-dependent ATPase activity. Represses the transcriptional activity of nuclear receptors | 0.949 |
EIF6 | GTPBP4 | ENSP00000363559 | ENSP00000354040 | eukaryotic translation initiation factor 6; Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. May behave as a stimulatory translation initiation factor downstream insulin/growth factors. Is also involved in ribosome biogenesis. Associates with pre-60S subunits in the nucleus and is involved in its nuclear export. Cytoplasmic release of TIF6 from 60S subunits and nuclear relocalization is promoted by a RACK1 (GNB2L1)-dependent protein kinase C activity | GTP binding protein 4; Involved in the biogenesis of the 60S ribosomal subunit (By similarity) | 0.992 |
EIF6 | METAP1D | ENSP00000363559 | ENSP00000315152 | eukaryotic translation initiation factor 6; Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. May behave as a stimulatory translation initiation factor downstream insulin/growth factors. Is also involved in ribosome biogenesis. Associates with pre-60S subunits in the nucleus and is involved in its nuclear export. Cytoplasmic release of TIF6 from 60S subunits and nuclear relocalization is promoted by a RACK1 (GNB2L1)-dependent protein kinase C activity | methionyl aminopeptidase type 1D (mitochondrial); Removes the N-terminal methionine from nascent proteins (By similarity). May play a role in colon tumorigenesis | 0.467 |
EIF6 | METAP2 | ENSP00000363559 | ENSP00000325312 | eukaryotic translation initiation factor 6; Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. May behave as a stimulatory translation initiation factor downstream insulin/growth factors. Is also involved in ribosome biogenesis. Associates with pre-60S subunits in the nucleus and is involved in its nuclear export. Cytoplasmic release of TIF6 from 60S subunits and nuclear relocalization is promoted by a RACK1 (GNB2L1)-dependent protein kinase C activity | methionyl aminopeptidase 2; Removes the N-terminal methionine from nascent proteins. The catalytic activity of human METAP2 toward Met-Val peptides is consistently two orders of magnitude higher than that of METAP1, suggesting that it is responsible for processing proteins containing N-terminal Met-Val and Met-Thr sequences in vivo | 0.464 |
EIF6 | MKI67IP | ENSP00000363559 | ENSP00000285814 | eukaryotic translation initiation factor 6; Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. May behave as a stimulatory translation initiation factor downstream insulin/growth factors. Is also involved in ribosome biogenesis. Associates with pre-60S subunits in the nucleus and is involved in its nuclear export. Cytoplasmic release of TIF6 from 60S subunits and nuclear relocalization is promoted by a RACK1 (GNB2L1)-dependent protein kinase C activity | MKI67 (FHA domain) interacting nucleolar phosphoprotein | 0.973 |