node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
AMT | SHMT1 | ENSP00000273588 | ENSP00000318868 | aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine (By similarity) | serine hydroxymethyltransferase 1 (soluble); Interconversion of serine and glycine (By similarity) | 0.985 |
AMT | TYMS | ENSP00000273588 | ENSP00000315644 | aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine (By similarity) | thymidylate synthetase; Contributes to the de novo mitochondrial thymidylate biosynthesis pathway | 0.929 |
CCNA1 | CCNE1 | ENSP00000255465 | ENSP00000262643 | cyclin A1; May be involved in the control of the cell cycle at the G1/S (start) and G2/M (mitosis) transitions. May primarily function in the control of the germline meiotic cell cycle and additionally in the control of mitotic cell cycle in some somatic cells | cyclin E1; Essential for the control of the cell cycle at the G1/S (start) transition | 0.959 |
CCNA1 | CDT1 | ENSP00000255465 | ENSP00000301019 | cyclin A1; May be involved in the control of the cell cycle at the G1/S (start) and G2/M (mitosis) transitions. May primarily function in the control of the germline meiotic cell cycle and additionally in the control of mitotic cell cycle in some somatic cells | chromatin licensing and DNA replication factor 1; Cooperates with CDC6 to promote the loading of the mini- chromosome maintenance complex onto chromatin to form the pre- replication complex necessary to initiate DNA replication. Binds DNA in a sequence-, strand-, and conformation-independent manner. Potential oncogene | 0.995 |
CCNA1 | E2F3 | ENSP00000255465 | ENSP00000262904 | cyclin A1; May be involved in the control of the cell cycle at the G1/S (start) and G2/M (mitosis) transitions. May primarily function in the control of the germline meiotic cell cycle and additionally in the control of mitotic cell cycle in some somatic cells | E2F transcription factor 3; Transcription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5’-TTTC[CG]CGC- 3’ found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The DRTF1/E2F complex functions in the control of cell-cycle progression from G1 to S phase. E2F3 binds specifically to RB1 in a cell-cycle dependent manner | 0.979 |
CCNA1 | ORC1 | ENSP00000255465 | ENSP00000360621 | cyclin A1; May be involved in the control of the cell cycle at the G1/S (start) and G2/M (mitosis) transitions. May primarily function in the control of the germline meiotic cell cycle and additionally in the control of mitotic cell cycle in some somatic cells | origin recognition complex, subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication | 0.977 |
CCNA1 | RRM2 | ENSP00000255465 | ENSP00000353770 | cyclin A1; May be involved in the control of the cell cycle at the G1/S (start) and G2/M (mitosis) transitions. May primarily function in the control of the germline meiotic cell cycle and additionally in the control of mitotic cell cycle in some somatic cells | ribonucleotide reductase M2; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. Inhibits Wnt signaling | 0.931 |
CCNA1 | TYMS | ENSP00000255465 | ENSP00000315644 | cyclin A1; May be involved in the control of the cell cycle at the G1/S (start) and G2/M (mitosis) transitions. May primarily function in the control of the germline meiotic cell cycle and additionally in the control of mitotic cell cycle in some somatic cells | thymidylate synthetase; Contributes to the de novo mitochondrial thymidylate biosynthesis pathway | 0.913 |
CCNA1 | UBC | ENSP00000255465 | ENSP00000344818 | cyclin A1; May be involved in the control of the cell cycle at the G1/S (start) and G2/M (mitosis) transitions. May primarily function in the control of the germline meiotic cell cycle and additionally in the control of mitotic cell cycle in some somatic cells | ubiquitin C | 0.618 |
CCNA1 | UBE2C | ENSP00000255465 | ENSP00000348838 | cyclin A1; May be involved in the control of the cell cycle at the G1/S (start) and G2/M (mitosis) transitions. May primarily function in the control of the germline meiotic cell cycle and additionally in the control of mitotic cell cycle in some somatic cells | ubiquitin-conjugating enzyme E2C; Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes ’Lys- 11’- and ’Lys-48’-linked polyubiquitination. Acts as an essential factor of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated ubiquitin ligase that controls progression through mitosis. Acts by initiating ’Lys-11’-linked polyubiquitin chains on APC/C substrates, leading to the degradation of APC/C substrates by the proteasome and promoting mitotic exit | 0.404 |
CCNE1 | CCNA1 | ENSP00000262643 | ENSP00000255465 | cyclin E1; Essential for the control of the cell cycle at the G1/S (start) transition | cyclin A1; May be involved in the control of the cell cycle at the G1/S (start) and G2/M (mitosis) transitions. May primarily function in the control of the germline meiotic cell cycle and additionally in the control of mitotic cell cycle in some somatic cells | 0.959 |
CCNE1 | CDT1 | ENSP00000262643 | ENSP00000301019 | cyclin E1; Essential for the control of the cell cycle at the G1/S (start) transition | chromatin licensing and DNA replication factor 1; Cooperates with CDC6 to promote the loading of the mini- chromosome maintenance complex onto chromatin to form the pre- replication complex necessary to initiate DNA replication. Binds DNA in a sequence-, strand-, and conformation-independent manner. Potential oncogene | 0.973 |
CCNE1 | E2F3 | ENSP00000262643 | ENSP00000262904 | cyclin E1; Essential for the control of the cell cycle at the G1/S (start) transition | E2F transcription factor 3; Transcription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5’-TTTC[CG]CGC- 3’ found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The DRTF1/E2F complex functions in the control of cell-cycle progression from G1 to S phase. E2F3 binds specifically to RB1 in a cell-cycle dependent manner | 0.997 |
CCNE1 | ORC1 | ENSP00000262643 | ENSP00000360621 | cyclin E1; Essential for the control of the cell cycle at the G1/S (start) transition | origin recognition complex, subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication | 0.939 |
CCNE1 | RRM2 | ENSP00000262643 | ENSP00000353770 | cyclin E1; Essential for the control of the cell cycle at the G1/S (start) transition | ribonucleotide reductase M2; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. Inhibits Wnt signaling | 0.937 |
CCNE1 | TYMS | ENSP00000262643 | ENSP00000315644 | cyclin E1; Essential for the control of the cell cycle at the G1/S (start) transition | thymidylate synthetase; Contributes to the de novo mitochondrial thymidylate biosynthesis pathway | 0.926 |
CCNE1 | UBC | ENSP00000262643 | ENSP00000344818 | cyclin E1; Essential for the control of the cell cycle at the G1/S (start) transition | ubiquitin C | 0.999 |
CDT1 | CCNA1 | ENSP00000301019 | ENSP00000255465 | chromatin licensing and DNA replication factor 1; Cooperates with CDC6 to promote the loading of the mini- chromosome maintenance complex onto chromatin to form the pre- replication complex necessary to initiate DNA replication. Binds DNA in a sequence-, strand-, and conformation-independent manner. Potential oncogene | cyclin A1; May be involved in the control of the cell cycle at the G1/S (start) and G2/M (mitosis) transitions. May primarily function in the control of the germline meiotic cell cycle and additionally in the control of mitotic cell cycle in some somatic cells | 0.995 |
CDT1 | CCNE1 | ENSP00000301019 | ENSP00000262643 | chromatin licensing and DNA replication factor 1; Cooperates with CDC6 to promote the loading of the mini- chromosome maintenance complex onto chromatin to form the pre- replication complex necessary to initiate DNA replication. Binds DNA in a sequence-, strand-, and conformation-independent manner. Potential oncogene | cyclin E1; Essential for the control of the cell cycle at the G1/S (start) transition | 0.973 |
CDT1 | E2F3 | ENSP00000301019 | ENSP00000262904 | chromatin licensing and DNA replication factor 1; Cooperates with CDC6 to promote the loading of the mini- chromosome maintenance complex onto chromatin to form the pre- replication complex necessary to initiate DNA replication. Binds DNA in a sequence-, strand-, and conformation-independent manner. Potential oncogene | E2F transcription factor 3; Transcription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5’-TTTC[CG]CGC- 3’ found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The DRTF1/E2F complex functions in the control of cell-cycle progression from G1 to S phase. E2F3 binds specifically to RB1 in a cell-cycle dependent manner | 0.798 |